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P0CE00

- MPH3_YEAST

UniProt

P0CE00 - MPH3_YEAST

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Protein

Alpha-glucosides permease MPH3

Gene

MPH3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

High-affinity uptake of maltose and maltotriose. Also transports alpha-methylglucoside, glucose and turanose but not melezitose or trehalose.2 Publications

GO - Molecular functioni

  1. alpha-glucoside transmembrane transporter activity Source: UniProtKB
  2. carbohydrate transmembrane transporter activity Source: SGD
  3. maltose transmembrane transporter activity Source: SGD

GO - Biological processi

  1. alpha-glucoside transport Source: UniProtKB
  2. carbohydrate transmembrane transport Source: GOC
  3. carbohydrate transport Source: SGD
  4. maltose metabolic process Source: UniProtKB-KW
  5. maltose transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Maltose metabolism, Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31769-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-glucosides permease MPH3
Alternative name(s):
Maltose transport protein 3
Gene namesi
Name:MPH3
Ordered Locus Names:YJR160C
ORF Names:J2400
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

SGDiS000003921. MPH3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602Alpha-glucosides permease MPH3PRO_0000391710Add
BLAST

Expressioni

Inductioni

By maltose and maltotriose. Repressed by glucose.1 Publication

Gene expression databases

GenevestigatoriP47186.

Interactioni

Protein-protein interaction databases

BioGridi33914. 42 interactions.
MINTiMINT-565339.

Structurei

3D structure databases

ProteinModelPortaliP0CE00.
SMRiP0CE00. Positions 112-550.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 106106CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini128 – 14215ExtracellularSequence AnalysisAdd
BLAST
Topological domaini164 – 17815CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini200 – 2001ExtracellularSequence Analysis
Topological domaini222 – 23413CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini256 – 27015ExtracellularSequence AnalysisAdd
BLAST
Topological domaini292 – 36372CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini385 – 39713ExtracellularSequence AnalysisAdd
BLAST
Topological domaini419 – 4268CytoplasmicSequence Analysis
Topological domaini448 – 45912ExtracellularSequence AnalysisAdd
BLAST
Topological domaini481 – 49212CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini514 – 52512ExtracellularSequence AnalysisAdd
BLAST
Topological domaini547 – 60256CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei107 – 12721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei143 – 16321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei364 – 38421Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei398 – 41821Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei427 – 44721Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei460 – 48021Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei493 – 51321Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei526 – 54621Helical; Name=12Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00720000109429.
HOGENOMiHOG000159003.
InParanoidiP0CE00.
KOiK08141.
OMAiGMDASNS.
OrthoDBiEOG7MKWG3.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CE00-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNLSFLINR RKENTSDSNV YPGKAKSHEP SWIEMDDQTK KDGLDIVHVE
60 70 80 90 100
FSPDTRAPSD SNKVITEIFD ATEDAKEADE SERGMPLATA LNTYPKAAAW
110 120 130 140 150
SLLVSTTLIM EGYDTAILGA FYALPIFQRK FGSQNDKTGE WEISASWQIG
160 170 180 190 200
LTLCYMAGEI VGLQLTGPSV DLVGNRYTLI IALFFLAAFT FILYFCNSLG
210 220 230 240 250
MIAVGQALCG MPWGCFQCLT VSYASEICPL ALRYYLTTYS NLCWLFGQLF
260 270 280 290 300
AAGIMKNSQK KYADSELGYK LPFALQWILP VPLALGIFFA PESPWWLVKK
310 320 330 340 350
GRFDEARRSL RRTLSGKGPE KEILVTLEVD KIKVTIDKEK RLTSKEGSYS
360 370 380 390 400
DCFEDKINRR RTRITCLCWA GQATCGSILI GYSTYFYEKA GVSTEMSFTF
410 420 430 440 450
SIIQYCLGIC ATFLSWWASK YFGRYDLYAF GLAFQTIVFF IIGGLGCSST
460 470 480 490 500
HGSKMGSGSL LMAVAFFYNL GIAPVVFCLV SEMPSSRLRT KTIILARNTY
510 520 530 540 550
NVVSIICSVL ILYQLNSKKW NWGAKSGFFW GVLCFCTLIW AVVDLPETAG
560 570 580 590 600
KTFVEINELF KLGVSARKFK STKVDPFVVK TPPKDVSHND PKGDIEASIA

EE
Length:602
Mass (Da):67,257
Last modified:March 2, 2010 - v1
Checksum:i75BDC04C164CFDF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49660 Genomic DNA. Translation: CAA89693.1.
BK006943 Genomic DNA. Translation: DAA08944.1.
PIRiS57190.
RefSeqiNP_012694.1. NM_001181818.1.

Genome annotation databases

EnsemblFungiiYJR160C; YJR160C; YJR160C.
GeneIDi853625.
KEGGisce:YJR160C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49660 Genomic DNA. Translation: CAA89693.1 .
BK006943 Genomic DNA. Translation: DAA08944.1 .
PIRi S57190.
RefSeqi NP_012694.1. NM_001181818.1.

3D structure databases

ProteinModelPortali P0CE00.
SMRi P0CE00. Positions 112-550.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33914. 42 interactions.
MINTi MINT-565339.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJR160C ; YJR160C ; YJR160C .
GeneIDi 853625.
KEGGi sce:YJR160C.

Organism-specific databases

SGDi S000003921. MPH3.

Phylogenomic databases

GeneTreei ENSGT00720000109429.
HOGENOMi HOG000159003.
InParanoidi P0CE00.
KOi K08141.
OMAi GMDASNS.
OrthoDBi EOG7MKWG3.

Enzyme and pathway databases

BioCyci YEAST:G3O-31769-MONOMER.

Miscellaneous databases

NextBioi 974493.

Gene expression databases

Genevestigatori P47186.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00879. SP. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae."
    Wieczorke R., Krampe S., Weierstall T., Freidel K., Hollenberg C.P., Boles E.
    FEBS Lett. 464:123-128(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Characterization of the putative maltose transporters encoded by YDL247w and YJR160c."
    Day R.E., Higgins V.J., Rogers P.J., Dawes I.W.
    Yeast 19:1015-1027(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiMPH3_YEAST
AccessioniPrimary (citable) accession number: P0CE00
Secondary accession number(s): D6VWX8, P47186, Q07787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3