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P0CE00

- MPH3_YEAST

UniProt

P0CE00 - MPH3_YEAST

Protein

Alpha-glucosides permease MPH3

Gene

MPH3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    High-affinity uptake of maltose and maltotriose. Also transports alpha-methylglucoside, glucose and turanose but not melezitose or trehalose.2 Publications

    GO - Molecular functioni

    1. alpha-glucoside transmembrane transporter activity Source: UniProtKB
    2. carbohydrate transmembrane transporter activity Source: SGD
    3. maltose transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. alpha-glucoside transport Source: UniProtKB
    2. carbohydrate transmembrane transport Source: GOC
    3. carbohydrate transport Source: SGD
    4. maltose metabolic process Source: UniProtKB-KW
    5. maltose transport Source: GOC

    Keywords - Biological processi

    Maltose metabolism, Sugar transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31769-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-glucosides permease MPH3
    Alternative name(s):
    Maltose transport protein 3
    Gene namesi
    Name:MPH3
    Ordered Locus Names:YJR160C
    ORF Names:J2400
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    SGDiS000003921. MPH3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 602602Alpha-glucosides permease MPH3PRO_0000391710Add
    BLAST

    Expressioni

    Inductioni

    By maltose and maltotriose. Repressed by glucose.1 Publication

    Gene expression databases

    GenevestigatoriP47186.

    Interactioni

    Protein-protein interaction databases

    BioGridi33914. 42 interactions.
    MINTiMINT-565339.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CE00.
    SMRiP0CE00. Positions 156-550.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 106106CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini128 – 14215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini164 – 17815CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini200 – 2001ExtracellularSequence Analysis
    Topological domaini222 – 23413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini256 – 27015ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 36372CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini385 – 39713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini419 – 4268CytoplasmicSequence Analysis
    Topological domaini448 – 45912ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini481 – 49212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini514 – 52512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini547 – 60256CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei107 – 12721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei364 – 38421Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei398 – 41821Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei427 – 44721Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei460 – 48021Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei493 – 51321Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei526 – 54621Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00720000109429.
    HOGENOMiHOG000159003.
    KOiK08141.
    OMAiGMDASNS.
    OrthoDBiEOG7MKWG3.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CE00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNLSFLINR RKENTSDSNV YPGKAKSHEP SWIEMDDQTK KDGLDIVHVE    50
    FSPDTRAPSD SNKVITEIFD ATEDAKEADE SERGMPLATA LNTYPKAAAW 100
    SLLVSTTLIM EGYDTAILGA FYALPIFQRK FGSQNDKTGE WEISASWQIG 150
    LTLCYMAGEI VGLQLTGPSV DLVGNRYTLI IALFFLAAFT FILYFCNSLG 200
    MIAVGQALCG MPWGCFQCLT VSYASEICPL ALRYYLTTYS NLCWLFGQLF 250
    AAGIMKNSQK KYADSELGYK LPFALQWILP VPLALGIFFA PESPWWLVKK 300
    GRFDEARRSL RRTLSGKGPE KEILVTLEVD KIKVTIDKEK RLTSKEGSYS 350
    DCFEDKINRR RTRITCLCWA GQATCGSILI GYSTYFYEKA GVSTEMSFTF 400
    SIIQYCLGIC ATFLSWWASK YFGRYDLYAF GLAFQTIVFF IIGGLGCSST 450
    HGSKMGSGSL LMAVAFFYNL GIAPVVFCLV SEMPSSRLRT KTIILARNTY 500
    NVVSIICSVL ILYQLNSKKW NWGAKSGFFW GVLCFCTLIW AVVDLPETAG 550
    KTFVEINELF KLGVSARKFK STKVDPFVVK TPPKDVSHND PKGDIEASIA 600
    EE 602
    Length:602
    Mass (Da):67,257
    Last modified:March 2, 2010 - v1
    Checksum:i75BDC04C164CFDF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49660 Genomic DNA. Translation: CAA89693.1.
    BK006943 Genomic DNA. Translation: DAA08944.1.
    PIRiS57190.
    RefSeqiNP_012694.1. NM_001181818.1.

    Genome annotation databases

    EnsemblFungiiYJR160C; YJR160C; YJR160C.
    GeneIDi853625.
    KEGGisce:YJR160C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49660 Genomic DNA. Translation: CAA89693.1 .
    BK006943 Genomic DNA. Translation: DAA08944.1 .
    PIRi S57190.
    RefSeqi NP_012694.1. NM_001181818.1.

    3D structure databases

    ProteinModelPortali P0CE00.
    SMRi P0CE00. Positions 156-550.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33914. 42 interactions.
    MINTi MINT-565339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJR160C ; YJR160C ; YJR160C .
    GeneIDi 853625.
    KEGGi sce:YJR160C.

    Organism-specific databases

    SGDi S000003921. MPH3.

    Phylogenomic databases

    GeneTreei ENSGT00720000109429.
    HOGENOMi HOG000159003.
    KOi K08141.
    OMAi GMDASNS.
    OrthoDBi EOG7MKWG3.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31769-MONOMER.

    Miscellaneous databases

    NextBioi 974493.

    Gene expression databases

    Genevestigatori P47186.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae."
      Wieczorke R., Krampe S., Weierstall T., Freidel K., Hollenberg C.P., Boles E.
      FEBS Lett. 464:123-128(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Characterization of the putative maltose transporters encoded by YDL247w and YJR160c."
      Day R.E., Higgins V.J., Rogers P.J., Dawes I.W.
      Yeast 19:1015-1027(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiMPH3_YEAST
    AccessioniPrimary (citable) accession number: P0CE00
    Secondary accession number(s): D6VWX8, P47186, Q07787
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3