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Protein

Alpha-glucosides permease MPH3

Gene

MPH3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity uptake of maltose and maltotriose. Also transports alpha-methylglucoside, glucose and turanose but not melezitose or trehalose.2 Publications

GO - Molecular functioni

  • alpha-glucoside transmembrane transporter activity Source: UniProtKB
  • carbohydrate transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: GO_Central
  • maltose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • alpha-glucoside transport Source: UniProtKB
  • carbohydrate transport Source: SGD
  • glucose import Source: GO_Central
  • hexose transmembrane transport Source: GO_Central
  • maltose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Maltose metabolism, Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31769-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-glucosides permease MPH3
Alternative name(s):
Maltose transport protein 3
Gene namesi
Name:MPH3
Ordered Locus Names:YJR160C
ORF Names:J2400
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR160C.
SGDiS000003921. MPH3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 106CytoplasmicSequence analysisAdd BLAST106
Transmembranei107 – 127Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini128 – 142ExtracellularSequence analysisAdd BLAST15
Transmembranei143 – 163Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini164 – 178CytoplasmicSequence analysisAdd BLAST15
Transmembranei179 – 199Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini200ExtracellularSequence analysis1
Transmembranei201 – 221Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini222 – 234CytoplasmicSequence analysisAdd BLAST13
Transmembranei235 – 255Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini256 – 270ExtracellularSequence analysisAdd BLAST15
Transmembranei271 – 291Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini292 – 363CytoplasmicSequence analysisAdd BLAST72
Transmembranei364 – 384Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini385 – 397ExtracellularSequence analysisAdd BLAST13
Transmembranei398 – 418Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini419 – 426CytoplasmicSequence analysis8
Transmembranei427 – 447Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini448 – 459ExtracellularSequence analysisAdd BLAST12
Transmembranei460 – 480Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini481 – 492CytoplasmicSequence analysisAdd BLAST12
Transmembranei493 – 513Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini514 – 525ExtracellularSequence analysisAdd BLAST12
Transmembranei526 – 546Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini547 – 602CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003917101 – 602Alpha-glucosides permease MPH3Add BLAST602

Proteomic databases

PRIDEiP0CE00.

Expressioni

Inductioni

By maltose and maltotriose. Repressed by glucose.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33914. 42 interactors.
MINTiMINT-565339.

Structurei

3D structure databases

ProteinModelPortaliP0CE00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000159003.
InParanoidiP0CE00.
KOiK08141.
OMAiRGDEWAY.
OrthoDBiEOG092C1DHG.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CE00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNLSFLINR RKENTSDSNV YPGKAKSHEP SWIEMDDQTK KDGLDIVHVE
60 70 80 90 100
FSPDTRAPSD SNKVITEIFD ATEDAKEADE SERGMPLATA LNTYPKAAAW
110 120 130 140 150
SLLVSTTLIM EGYDTAILGA FYALPIFQRK FGSQNDKTGE WEISASWQIG
160 170 180 190 200
LTLCYMAGEI VGLQLTGPSV DLVGNRYTLI IALFFLAAFT FILYFCNSLG
210 220 230 240 250
MIAVGQALCG MPWGCFQCLT VSYASEICPL ALRYYLTTYS NLCWLFGQLF
260 270 280 290 300
AAGIMKNSQK KYADSELGYK LPFALQWILP VPLALGIFFA PESPWWLVKK
310 320 330 340 350
GRFDEARRSL RRTLSGKGPE KEILVTLEVD KIKVTIDKEK RLTSKEGSYS
360 370 380 390 400
DCFEDKINRR RTRITCLCWA GQATCGSILI GYSTYFYEKA GVSTEMSFTF
410 420 430 440 450
SIIQYCLGIC ATFLSWWASK YFGRYDLYAF GLAFQTIVFF IIGGLGCSST
460 470 480 490 500
HGSKMGSGSL LMAVAFFYNL GIAPVVFCLV SEMPSSRLRT KTIILARNTY
510 520 530 540 550
NVVSIICSVL ILYQLNSKKW NWGAKSGFFW GVLCFCTLIW AVVDLPETAG
560 570 580 590 600
KTFVEINELF KLGVSARKFK STKVDPFVVK TPPKDVSHND PKGDIEASIA

EE
Length:602
Mass (Da):67,257
Last modified:March 2, 2010 - v1
Checksum:i75BDC04C164CFDF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49660 Genomic DNA. Translation: CAA89693.1.
BK006943 Genomic DNA. Translation: DAA08944.1.
PIRiS57190.
RefSeqiNP_012694.1. NM_001181818.1.

Genome annotation databases

EnsemblFungiiYJR160C; YJR160C; YJR160C.
GeneIDi853625.
KEGGisce:YJR160C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49660 Genomic DNA. Translation: CAA89693.1.
BK006943 Genomic DNA. Translation: DAA08944.1.
PIRiS57190.
RefSeqiNP_012694.1. NM_001181818.1.

3D structure databases

ProteinModelPortaliP0CE00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33914. 42 interactors.
MINTiMINT-565339.

Proteomic databases

PRIDEiP0CE00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR160C; YJR160C; YJR160C.
GeneIDi853625.
KEGGisce:YJR160C.

Organism-specific databases

EuPathDBiFungiDB:YJR160C.
SGDiS000003921. MPH3.

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000159003.
InParanoidiP0CE00.
KOiK08141.
OMAiRGDEWAY.
OrthoDBiEOG092C1DHG.

Enzyme and pathway databases

BioCyciYEAST:G3O-31769-MONOMER.

Miscellaneous databases

PROiP0CE00.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPH3_YEAST
AccessioniPrimary (citable) accession number: P0CE00
Secondary accession number(s): D6VWX8, P47186, Q07787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.