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Protein

Aquaporin-like protein 2

Gene

AQY2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures (By similarity). Is non-functional in most laboratory strains.By similarity

Caution

This is a truncated version of aquaporin-2. In strain S288c and many laboratory strains, a natural 11 bp deletion in position 109 leads to a frameshift, which disrupts the gene coding for this protein and produces two ORFs YLL052C and YLL053C. A contiguous sequence for aquaporin-2 can be found in strain Sigma 1278B (AC P0CD89).Curated

GO - Molecular functioni

  • water channel activity Source: SGD

GO - Biological processi

  • ion transmembrane transport Source: GO_Central
  • transmembrane transport Source: SGD
  • water transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-32151-MONOMER
ReactomeiR-SCE-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-SCE-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-SCE-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-SCE-432047 Passive transport by Aquaporins

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-like protein 2
Alternative name(s):
Truncated aquaporin-2
Gene namesi
Name:AQY2
Synonyms:AQY2-2
Ordered Locus Names:YLL052C
ORF Names:L0590
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL052C
SGDiS000003975 AQY2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicBy similarityAdd BLAST47
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 89ExtracellularBy similarityAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 149CytoplasmicBy similarityAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003916511 – 149Aquaporin-like protein 2Add BLAST149

Proteomic databases

PaxDbiP0CD90

Expressioni

Inductioni

During exponential phase in rich medium and repressed in minimum medium, hyper-osmolar medium or in sporulating conditions.By similarity

Interactioni

Protein-protein interaction databases

BioGridi31263, 11 interactors
STRINGi4932.YLL052C

Structurei

3D structure databases

ProteinModelPortaliP0CD90
SMRiP0CD90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119223
KOiK09885
OrthoDBiEOG092C4E37

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR034294 Aquaporin_transptr
PANTHERiPTHR19139 PTHR19139, 1 hit
SUPFAMiSSF81338 SSF81338, 1 hit

Sequencei

Sequence statusi: Complete.

P0CD90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNESNDLEK NISHLDPTGV DNAYIPPEQP ETKHSRFNID RDTLRNHFIA
60 70 80 90 100
AVGEFCGTFM FLWCAYVICN VANHDVALTT EPEGSHPGQL IMIALGFGFS
110 120 130 140
VMFSIWCFWW GFEPSRFSLF VFGQSHLTSQ MCSDVVSSDH CWDGCWWCR
Length:149
Mass (Da):17,024
Last modified:March 2, 2010 - v1
Checksum:i197E5A42A2F7495E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73158 Genomic DNA Translation: CAA97506.1
Z47973 Genomic DNA Translation: CAA88005.1
BK006945 Genomic DNA Translation: DAA09272.1
PIRiS50968
RefSeqiNP_013048.1, NM_001181872.1

Genome annotation databases

EnsemblFungiiYLL052C; YLL052C; YLL052C
GeneIDi850674
KEGGisce:YLL052C

Similar proteinsi

Entry informationi

Entry nameiAQY2_YEAST
AccessioniPrimary (citable) accession number: P0CD90
Secondary accession number(s): D6VXV6
, O93938, Q12258, Q12302, Q9C411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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