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P0CD90

- AQY2_YEAST

UniProt

P0CD90 - AQY2_YEAST

Protein

Aquaporin-like protein 2

Gene

AQY2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures By similarity. Is non-functional in most laboratory strains.By similarity

    GO - Molecular functioni

    1. water channel activity Source: SGD

    GO - Biological processi

    1. water transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32151-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aquaporin-like protein 2
    Alternative name(s):
    Truncated aquaporin-2
    Gene namesi
    Name:AQY2
    Synonyms:AQY2-2
    Ordered Locus Names:YLL052C
    ORF Names:L0590
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    SGDiS000003975. AQY2.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell membrane By similarity; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: SGD
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 149149Aquaporin-like protein 2PRO_0000391651Add
    BLAST

    Expressioni

    Inductioni

    During exponential phase in rich medium and repressed in minimum medium, hyper-osmolar medium or in sporulating conditions.By similarity

    Gene expression databases

    GenevestigatoriO93938.

    Interactioni

    Protein-protein interaction databases

    BioGridi31263. 10 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CD90.
    SMRiP0CD90. Positions 16-106.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4747CytoplasmicBy similarityAdd
    BLAST
    Topological domaini69 – 8921ExtracellularBy similarityAdd
    BLAST
    Topological domaini111 – 14939CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 6821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00740000115463.
    KOiK09885.
    OrthoDBiEOG7TJ3VH.

    Family and domain databases

    Gene3Di1.20.1080.10. 1 hit.
    InterProiIPR023271. Aquaporin-like.
    IPR000425. MIP.
    [Graphical view]
    PANTHERiPTHR19139. PTHR19139. 1 hit.
    SUPFAMiSSF81338. SSF81338. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0CD90-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNESNDLEK NISHLDPTGV DNAYIPPEQP ETKHSRFNID RDTLRNHFIA    50
    AVGEFCGTFM FLWCAYVICN VANHDVALTT EPEGSHPGQL IMIALGFGFS 100
    VMFSIWCFWW GFEPSRFSLF VFGQSHLTSQ MCSDVVSSDH CWDGCWWCR 149
    Length:149
    Mass (Da):17,024
    Last modified:March 2, 2010 - v1
    Checksum:i197E5A42A2F7495E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z73158 Genomic DNA. Translation: CAA97506.1.
    Z47973 Genomic DNA. Translation: CAA88005.1.
    BK006945 Genomic DNA. Translation: DAA09272.1.
    PIRiS50968.
    RefSeqiNP_013048.1. NM_001181872.1.

    Genome annotation databases

    EnsemblFungiiYLL052C; YLL052C; YLL052C.
    GeneIDi850674.
    KEGGisce:YLL052C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z73158 Genomic DNA. Translation: CAA97506.1 .
    Z47973 Genomic DNA. Translation: CAA88005.1 .
    BK006945 Genomic DNA. Translation: DAA09272.1 .
    PIRi S50968.
    RefSeqi NP_013048.1. NM_001181872.1.

    3D structure databases

    ProteinModelPortali P0CD90.
    SMRi P0CD90. Positions 16-106.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31263. 10 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLL052C ; YLL052C ; YLL052C .
    GeneIDi 850674.
    KEGGi sce:YLL052C.

    Organism-specific databases

    SGDi S000003975. AQY2.

    Phylogenomic databases

    GeneTreei ENSGT00740000115463.
    KOi K09885.
    OrthoDBi EOG7TJ3VH.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32151-MONOMER.

    Miscellaneous databases

    NextBioi 966665.

    Gene expression databases

    Genevestigatori O93938.

    Family and domain databases

    Gene3Di 1.20.1080.10. 1 hit.
    InterProi IPR023271. Aquaporin-like.
    IPR000425. MIP.
    [Graphical view ]
    PANTHERi PTHR19139. PTHR19139. 1 hit.
    SUPFAMi SSF81338. SSF81338. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Polymorphism of Saccharomyces cerevisiae aquaporins."
      Laize V., Tacnet F., Ripoche P., Hohmann S.
      Yeast 16:897-903(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYMORPHISM.
    4. "Aquaporins in Saccharomyces: characterization of a second functional water channel protein."
      Carbrey J.M., Bonhivers M., Boeke J.D., Agre P.
      Proc. Natl. Acad. Sci. U.S.A. 98:1000-1005(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYMORPHISM.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAQY2_YEAST
    AccessioniPrimary (citable) accession number: P0CD90
    Secondary accession number(s): D6VXV6
    , O93938, Q12258, Q12302, Q9C411
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    This is a truncated version of aquaporin-2. In strain S288c and many laboratory strains, a natural 11 bp deletion in position 109 leads to a frameshift, which disrupts the gene coding for this protein and produces two ORFs YLL052C and YLL053C. A contiguous sequence for aquaporin-2 can be found in strain Sigma 1278B (AC P0CD89).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3