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P0CD90

- AQY2_YEAST

UniProt

P0CD90 - AQY2_YEAST

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Protein
Aquaporin-like protein 2
Gene
AQY2, AQY2-2, YLL052C, L0590
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures By similarity. Is non-functional in most laboratory strains.

GO - Molecular functioni

  1. water channel activity Source: SGD

GO - Biological processi

  1. water transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32151-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-like protein 2
Alternative name(s):
Truncated aquaporin-2
Gene namesi
Name:AQY2
Synonyms:AQY2-2
Ordered Locus Names:YLL052C
ORF Names:L0590
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

SGDiS000003975. AQY2.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane By similarity; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747Cytoplasmic By similarity
Add
BLAST
Transmembranei48 – 6821Helical; Reviewed prediction
Add
BLAST
Topological domaini69 – 8921Extracellular By similarity
Add
BLAST
Transmembranei90 – 11021Helical; Reviewed prediction
Add
BLAST
Topological domaini111 – 14939Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Aquaporin-like protein 2
PRO_0000391651Add
BLAST

Expressioni

Inductioni

During exponential phase in rich medium and repressed in minimum medium, hyper-osmolar medium or in sporulating conditions By similarity.

Gene expression databases

GenevestigatoriO93938.

Interactioni

Protein-protein interaction databases

BioGridi31263. 10 interactions.

Structurei

3D structure databases

ProteinModelPortaliP0CD90.
SMRiP0CD90. Positions 16-106.

Family & Domainsi

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00740000115463.
KOiK09885.
OrthoDBiEOG7TJ3VH.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
SUPFAMiSSF81338. SSF81338. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CD90-1 [UniParc]FASTAAdd to Basket

« Hide

MSNESNDLEK NISHLDPTGV DNAYIPPEQP ETKHSRFNID RDTLRNHFIA    50
AVGEFCGTFM FLWCAYVICN VANHDVALTT EPEGSHPGQL IMIALGFGFS 100
VMFSIWCFWW GFEPSRFSLF VFGQSHLTSQ MCSDVVSSDH CWDGCWWCR 149
Length:149
Mass (Da):17,024
Last modified:March 2, 2010 - v1
Checksum:i197E5A42A2F7495E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73158 Genomic DNA. Translation: CAA97506.1.
Z47973 Genomic DNA. Translation: CAA88005.1.
BK006945 Genomic DNA. Translation: DAA09272.1.
PIRiS50968.
RefSeqiNP_013048.1. NM_001181872.1.

Genome annotation databases

EnsemblFungiiYLL052C; YLL052C; YLL052C.
GeneIDi850674.
KEGGisce:YLL052C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73158 Genomic DNA. Translation: CAA97506.1 .
Z47973 Genomic DNA. Translation: CAA88005.1 .
BK006945 Genomic DNA. Translation: DAA09272.1 .
PIRi S50968.
RefSeqi NP_013048.1. NM_001181872.1.

3D structure databases

ProteinModelPortali P0CD90.
SMRi P0CD90. Positions 16-106.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31263. 10 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLL052C ; YLL052C ; YLL052C .
GeneIDi 850674.
KEGGi sce:YLL052C.

Organism-specific databases

SGDi S000003975. AQY2.

Phylogenomic databases

GeneTreei ENSGT00740000115463.
KOi K09885.
OrthoDBi EOG7TJ3VH.

Enzyme and pathway databases

BioCyci YEAST:G3O-32151-MONOMER.

Miscellaneous databases

NextBioi 966665.

Gene expression databases

Genevestigatori O93938.

Family and domain databases

Gene3Di 1.20.1080.10. 1 hit.
InterProi IPR023271. Aquaporin-like.
IPR000425. MIP.
[Graphical view ]
PANTHERi PTHR19139. PTHR19139. 1 hit.
SUPFAMi SSF81338. SSF81338. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Polymorphism of Saccharomyces cerevisiae aquaporins."
    Laize V., Tacnet F., Ripoche P., Hohmann S.
    Yeast 16:897-903(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM.
  4. "Aquaporins in Saccharomyces: characterization of a second functional water channel protein."
    Carbrey J.M., Bonhivers M., Boeke J.D., Agre P.
    Proc. Natl. Acad. Sci. U.S.A. 98:1000-1005(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAQY2_YEAST
AccessioniPrimary (citable) accession number: P0CD90
Secondary accession number(s): D6VXV6
, O93938, Q12258, Q12302, Q9C411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

This is a truncated version of aquaporin-2. In strain S288c and many laboratory strains, a natural 11 bp deletion in position 109 leads to a frameshift, which disrupts the gene coding for this protein and produces two ORFs YLL052C and YLL053C. A contiguous sequence for aquaporin-2 can be found in strain Sigma 1278B (AC P0CD89).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3

Similar proteinsi