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P0CD90 (AQY2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aquaporin-like protein 2
Alternative name(s):
Truncated aquaporin-2
Gene names
Name:AQY2
Synonyms:AQY2-2
Ordered Locus Names:YLL052C
ORF Names:L0590
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length149 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures By similarity. Is non-functional in most laboratory strains.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane By similarity; Multi-pass membrane protein Ref.5.

Induction

During exponential phase in rich medium and repressed in minimum medium, hyper-osmolar medium or in sporulating conditions By similarity.

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Caution

This is a truncated version of aquaporin-2. In strain S288c and many laboratory strains, a natural 11 bp deletion in position 109 leads to a frameshift, which disrupts the gene coding for this protein and produces two ORFs YLL052C and YLL053C. A contiguous sequence for aquaporin-2 can be found in strain Sigma 1278B (AC P0CD89).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 149149Aquaporin-like protein 2
PRO_0000391651

Regions

Topological domain1 – 4747Cytoplasmic By similarity
Transmembrane48 – 6821Helical; Potential
Topological domain69 – 8921Extracellular By similarity
Transmembrane90 – 11021Helical; Potential
Topological domain111 – 14939Cytoplasmic By similarity

Sequences

Sequence LengthMass (Da)Tools
P0CD90 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: 197E5A42A2F7495E

FASTA14917,024
        10         20         30         40         50         60 
MSNESNDLEK NISHLDPTGV DNAYIPPEQP ETKHSRFNID RDTLRNHFIA AVGEFCGTFM 

        70         80         90        100        110        120 
FLWCAYVICN VANHDVALTT EPEGSHPGQL IMIALGFGFS VMFSIWCFWW GFEPSRFSLF 

       130        140 
VFGQSHLTSQ MCSDVVSSDH CWDGCWWCR 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Polymorphism of Saccharomyces cerevisiae aquaporins."
Laize V., Tacnet F., Ripoche P., Hohmann S.
Yeast 16:897-903(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.
[4]"Aquaporins in Saccharomyces: characterization of a second functional water channel protein."
Carbrey J.M., Bonhivers M., Boeke J.D., Agre P.
Proc. Natl. Acad. Sci. U.S.A. 98:1000-1005(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z73158 Genomic DNA. Translation: CAA97506.1.
Z47973 Genomic DNA. Translation: CAA88005.1.
BK006945 Genomic DNA. Translation: DAA09272.1.
PIRS50968.
RefSeqNP_013048.1. NM_001181872.1.

3D structure databases

ProteinModelPortalP0CD90.
SMRP0CD90. Positions 16-106.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31263. 10 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLL052C; YLL052C; YLL052C.
GeneID850674.
KEGGsce:YLL052C.

Organism-specific databases

SGDS000003975. AQY2.

Phylogenomic databases

GeneTreeENSGT00740000115463.
KOK09885.
OrthoDBEOG7TJ3VH.

Enzyme and pathway databases

BioCycYEAST:G3O-32151-MONOMER.

Gene expression databases

GenevestigatorO93938.

Family and domain databases

Gene3D1.20.1080.10. 1 hit.
InterProIPR023271. Aquaporin-like.
IPR000425. MIP.
[Graphical view]
PANTHERPTHR19139. PTHR19139. 1 hit.
SUPFAMSSF81338. SSF81338. 1 hit.
ProtoNetSearch...

Other

NextBio966665.

Entry information

Entry nameAQY2_YEAST
AccessionPrimary (citable) accession number: P0CD90
Secondary accession number(s): D6VXV6 expand/collapse secondary AC list , O93938, Q12258, Q12302, Q9C411
Entry history
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families