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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei154SubstrateBy similarity1
Binding sitei207ATPBy similarity1
Binding sitei299ATP; via carbonyl oxygenBy similarity1
Binding sitei330ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi357 – 360ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-739-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:CT_693
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001459291 – 403Phosphoglycerate kinaseAdd BLAST403

Proteomic databases

PRIDEiP0CD78

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0CD78
SMRiP0CD78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingBy similarity3
Regioni59 – 62Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
InParanoidiP0CD78
KOiK00927
OMAiDMIFDIG

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0CD78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLSIRDLS LEGKKVLVRV DFNVPIKDGK ILDDVRIHSA MPTIHYLLKQ
60 70 80 90 100
DAAVILVSHV GRPKGGVFEE AYSLAPIVPV LEGYLGHHVP LSPDCIGEVA
110 120 130 140 150
RQAVAQLSPG RVLLLENVRF HKGEEHSDED PSFAIELAAY ADFYVNDAFG
160 170 180 190 200
TSHRKHASVY RVPQLFPDRA AAGFLMEKEL EFLGQHLLVE PKRPFTAILG
210 220 230 240 250
GAKMSSKIGV IEALLSCVDH LVLAGGMGYT FLRAMNRQVG NSLVEESGIP
260 270 280 290 300
LAKKVLEKAQ ALGVKIHLPV DAKVAKQCDS GEDWRELSIQ EGIPEGLAGF
310 320 330 340 350
DIGAQTIELF SKVIQESATI FWNGPVGVYE VPPFDQGSKA IAQCLASHSS
360 370 380 390 400
AVTVVGGGDA AAVVALAGCA SQISHVSTGG GASLEFLEKG SLPGTEILSP

AQS
Length:403
Mass (Da):42,997
Last modified:February 9, 2010 - v1
Checksum:iA91632279844C334
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC68288.1
PIRiA71484
RefSeqiNP_220212.1, NC_000117.1
WP_009872068.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC68288; AAC68288; CT_693
GeneIDi35556950
884491
KEGGictr:CT_693
PATRICifig|272561.5.peg.762

Similar proteinsi

Entry informationi

Entry nameiPGK_CHLTR
AccessioniPrimary (citable) accession number: P0CD78
Secondary accession number(s): O84699, P94686
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: May 23, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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