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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei154SubstrateBy similarity1
Binding sitei207ATPBy similarity1
Binding sitei299ATP; via carbonyl oxygenBy similarity1
Binding sitei330ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi357 – 360ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:CT_693
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001459291 – 403Phosphoglycerate kinaseAdd BLAST403

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi272561.CT693.

Structurei

3D structure databases

ProteinModelPortaliP0CD78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingBy similarity3
Regioni59 – 62Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4105BZA. Bacteria.
COG0126. LUCA.
InParanoidiP0CD78.
KOiK00927.
OMAiEVLMVEN.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CD78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLSIRDLS LEGKKVLVRV DFNVPIKDGK ILDDVRIHSA MPTIHYLLKQ
60 70 80 90 100
DAAVILVSHV GRPKGGVFEE AYSLAPIVPV LEGYLGHHVP LSPDCIGEVA
110 120 130 140 150
RQAVAQLSPG RVLLLENVRF HKGEEHSDED PSFAIELAAY ADFYVNDAFG
160 170 180 190 200
TSHRKHASVY RVPQLFPDRA AAGFLMEKEL EFLGQHLLVE PKRPFTAILG
210 220 230 240 250
GAKMSSKIGV IEALLSCVDH LVLAGGMGYT FLRAMNRQVG NSLVEESGIP
260 270 280 290 300
LAKKVLEKAQ ALGVKIHLPV DAKVAKQCDS GEDWRELSIQ EGIPEGLAGF
310 320 330 340 350
DIGAQTIELF SKVIQESATI FWNGPVGVYE VPPFDQGSKA IAQCLASHSS
360 370 380 390 400
AVTVVGGGDA AAVVALAGCA SQISHVSTGG GASLEFLEKG SLPGTEILSP

AQS
Length:403
Mass (Da):42,997
Last modified:February 9, 2010 - v1
Checksum:iA91632279844C334
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68288.1.
PIRiA71484.
RefSeqiNP_220212.1. NC_000117.1.
WP_009872068.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC68288; AAC68288; CT_693.
GeneIDi884491.
KEGGictr:CT_693.
PATRICi20381048. VBIChlTra43535_0762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC68288.1.
PIRiA71484.
RefSeqiNP_220212.1. NC_000117.1.
WP_009872068.1. NC_000117.1.

3D structure databases

ProteinModelPortaliP0CD78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT693.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC68288; AAC68288; CT_693.
GeneIDi884491.
KEGGictr:CT_693.
PATRICi20381048. VBIChlTra43535_0762.

Phylogenomic databases

eggNOGiENOG4105BZA. Bacteria.
COG0126. LUCA.
InParanoidiP0CD78.
KOiK00927.
OMAiEVLMVEN.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGK_CHLTR
AccessioniPrimary (citable) accession number: P0CD78
Secondary accession number(s): O84699, P94686
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: September 7, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.