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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei347 – 3471Proton donorBy similarity
Active sitei378 – 3781By similarity
Active sitei493 – 4931By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:CT_378
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Glucose-6-phosphate isomerasePRO_0000180620Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CD72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

InParanoidiP0CD72.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CD72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMGKGFLDCE SLVALQEMAL HPIDLTASGC LSEERIQKNS LSAEGFTYSY
60 70 80 90 100
ATERVDDRCL EALQGLTEER ELIKQMECMQ QGAIMNRIEG FQSESRPVLH
110 120 130 140 150
TATRAWVRDQ DLHEEAAAIA RHSKEEALRL AEFLYIARAK FSTLVQMGIG
160 170 180 190 200
GSELGPKAMY FAMQGSCPSD KRIFFVSNID PDNAAEVLRE IDLEQTLVVV
210 220 230 240 250
VSKSGTTLEP AANEELFRQA YQNKGLSIAE HFVAVTSQGS PMDDKSRYLE
260 270 280 290 300
VFHLWDSIGG RFSATSMVGG VVLGFAFGYE AFIEFLQGAA AIDAHALTPK
310 320 330 340 350
MRENLPLLSA MLGVWNRNLL GYPTTAVIPY STGLKYFTAH LQQCGMESNG
360 370 380 390 400
KSISREGKEI SFRTSPIIWG DVGTNCQHSF FQSLHQGTDI VPVEFIGFLH
410 420 430 440 450
NQRGLDCVLS GSSSSQKLFA NLVAQSLALA QGRDNANSNK RFKGNRPSSI
460 470 480 490 500
LVAQQLSPRI AGSLLAFYEH KFAFQGFCWG INSFDQEGVS LGKELATQII
510 520
GIMSGNAPVE FSEARGMLRL FNVLT
Length:525
Mass (Da):57,771
Last modified:February 9, 2010 - v1
Checksum:i41F37FEDFC4C233E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67974.1.
PIRiF71521.
RefSeqiNP_219887.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67974; AAC67974; CT_378.
GeneIDi884740.
KEGGictr:CT_378.
PATRICi20380305. VBIChlTra43535_0407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67974.1.
PIRiF71521.
RefSeqiNP_219887.1. NC_000117.1.

3D structure databases

ProteinModelPortaliP0CD72.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67974; AAC67974; CT_378.
GeneIDi884740.
KEGGictr:CT_378.
PATRICi20380305. VBIChlTra43535_0407.

Phylogenomic databases

InParanoidiP0CD72.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiG6PI_CHLTR
AccessioniPrimary (citable) accession number: P0CD72
Secondary accession number(s): O84382, Q46402
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: January 7, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.