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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. Probable ATP-dependent 6-phosphofructokinase (pfkA_1), 6-phosphofructokinase (pfkA_2)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei347Proton donorBy similarity1
Active sitei378By similarity1
Active sitei493By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:CT_378
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806201 – 525Glucose-6-phosphate isomeraseAdd BLAST525

Interactioni

Protein-protein interaction databases

STRINGi272561.CT378.

Structurei

3D structure databases

ProteinModelPortaliP0CD72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiENOG4105C89. Bacteria.
COG0166. LUCA.
InParanoidiP0CD72.
KOiK01810.
OMAiSHLIAPY.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CD72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGKGFLDCE SLVALQEMAL HPIDLTASGC LSEERIQKNS LSAEGFTYSY
60 70 80 90 100
ATERVDDRCL EALQGLTEER ELIKQMECMQ QGAIMNRIEG FQSESRPVLH
110 120 130 140 150
TATRAWVRDQ DLHEEAAAIA RHSKEEALRL AEFLYIARAK FSTLVQMGIG
160 170 180 190 200
GSELGPKAMY FAMQGSCPSD KRIFFVSNID PDNAAEVLRE IDLEQTLVVV
210 220 230 240 250
VSKSGTTLEP AANEELFRQA YQNKGLSIAE HFVAVTSQGS PMDDKSRYLE
260 270 280 290 300
VFHLWDSIGG RFSATSMVGG VVLGFAFGYE AFIEFLQGAA AIDAHALTPK
310 320 330 340 350
MRENLPLLSA MLGVWNRNLL GYPTTAVIPY STGLKYFTAH LQQCGMESNG
360 370 380 390 400
KSISREGKEI SFRTSPIIWG DVGTNCQHSF FQSLHQGTDI VPVEFIGFLH
410 420 430 440 450
NQRGLDCVLS GSSSSQKLFA NLVAQSLALA QGRDNANSNK RFKGNRPSSI
460 470 480 490 500
LVAQQLSPRI AGSLLAFYEH KFAFQGFCWG INSFDQEGVS LGKELATQII
510 520
GIMSGNAPVE FSEARGMLRL FNVLT
Length:525
Mass (Da):57,771
Last modified:February 9, 2010 - v1
Checksum:i41F37FEDFC4C233E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67974.1.
PIRiF71521.
RefSeqiNP_219887.1. NC_000117.1.
WP_009871730.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67974; AAC67974; CT_378.
GeneIDi884740.
KEGGictr:CT_378.
PATRICi20380305. VBIChlTra43535_0407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67974.1.
PIRiF71521.
RefSeqiNP_219887.1. NC_000117.1.
WP_009871730.1. NC_000117.1.

3D structure databases

ProteinModelPortaliP0CD72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT378.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67974; AAC67974; CT_378.
GeneIDi884740.
KEGGictr:CT_378.
PATRICi20380305. VBIChlTra43535_0407.

Phylogenomic databases

eggNOGiENOG4105C89. Bacteria.
COG0166. LUCA.
InParanoidiP0CD72.
KOiK01810.
OMAiSHLIAPY.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_CHLTR
AccessioniPrimary (citable) accession number: P0CD72
Secondary accession number(s): O84382, Q46402
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: September 7, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.