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Protein

Alpha-glucosidase

Gene

malA

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Major soluble alpha-glucosidase.By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei320By similarity1
Active sitei323By similarity1
Active sitei416Proton donorBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.20. 6163.

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-glucosidase (EC:3.2.1.20)
Alternative name(s):
Maltase
Gene namesi
Name:malA
Ordered Locus Names:SSO3051
ORF Names:C23_036
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001853671 – 693Alpha-glucosidaseAdd BLAST693

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO3051.

Structurei

Secondary structure

1693
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Beta strandi10 – 19Combined sources10
Helixi38 – 41Combined sources4
Beta strandi43 – 48Combined sources6
Beta strandi51 – 57Combined sources7
Beta strandi63 – 66Combined sources4
Beta strandi78 – 83Combined sources6
Beta strandi99 – 101Combined sources3
Beta strandi104 – 109Combined sources6
Beta strandi112 – 118Combined sources7
Beta strandi124 – 132Combined sources9
Beta strandi135 – 143Combined sources9
Beta strandi145 – 151Combined sources7
Helixi155 – 166Combined sources12
Helixi174 – 177Combined sources4
Beta strandi178 – 182Combined sources5
Helixi189 – 201Combined sources13
Beta strandi206 – 211Combined sources6
Helixi213 – 215Combined sources3
Turni226 – 228Combined sources3
Helixi232 – 241Combined sources10
Beta strandi245 – 250Combined sources6
Helixi261 – 266Combined sources6
Beta strandi276 – 278Combined sources3
Beta strandi280 – 283Combined sources4
Beta strandi286 – 289Combined sources4
Helixi296 – 310Combined sources15
Turni311 – 313Combined sources3
Beta strandi316 – 319Combined sources4
Turni322 – 324Combined sources3
Helixi328 – 337Combined sources10
Helixi348 – 351Combined sources4
Beta strandi357 – 361Combined sources5
Beta strandi364 – 367Combined sources4
Helixi368 – 371Combined sources4
Helixi372 – 374Combined sources3
Helixi375 – 389Combined sources15
Beta strandi397 – 400Combined sources4
Helixi406 – 408Combined sources3
Beta strandi411 – 413Combined sources3
Helixi421 – 435Combined sources15
Turni436 – 438Combined sources3
Beta strandi441 – 443Combined sources3
Beta strandi452 – 455Combined sources4
Helixi461 – 470Combined sources10
Turni471 – 473Combined sources3
Beta strandi477 – 479Combined sources3
Helixi490 – 492Combined sources3
Helixi495 – 525Combined sources31
Beta strandi529 – 531Combined sources3
Helixi533 – 536Combined sources4
Helixi541 – 545Combined sources5
Beta strandi550 – 552Combined sources3
Turni553 – 555Combined sources3
Beta strandi556 – 558Combined sources3
Beta strandi563 – 567Combined sources5
Beta strandi569 – 572Combined sources4
Beta strandi574 – 579Combined sources6
Turni580 – 582Combined sources3
Beta strandi585 – 593Combined sources9
Beta strandi596 – 598Combined sources3
Beta strandi600 – 610Combined sources11
Helixi611 – 613Combined sources3
Beta strandi614 – 624Combined sources11
Beta strandi630 – 633Combined sources4
Beta strandi635 – 642Combined sources8
Beta strandi644 – 652Combined sources9
Beta strandi659 – 662Combined sources4
Beta strandi667 – 669Combined sources3
Beta strandi671 – 674Combined sources4
Beta strandi677 – 693Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G3MX-ray2.55A/B/C/D/E/F5-693[»]
2G3NX-ray2.55A/B/C/D/E/F5-693[»]
ProteinModelPortaliP0CD66.
SMRiP0CD66.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CD66.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Phylogenomic databases

eggNOGiarCOG03663. Archaea.
COG1501. LUCA.
HOGENOMiHOG000033867.
InParanoidiP0CD66.
KOiK01187.
OMAiFTETNDC.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR030458. Glyco_hydro_31_AS.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CD66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTIKIYENK GVYKVVIGEP FPPIEFPLEQ KISSNKSLSE LGLTIVQQGN
60 70 80 90 100
KVIVEKSLDL KEHIIGLGEK AFELDRKRKR YVMYNVDAGA YKKYQDPLYV
110 120 130 140 150
SIPLFISVKD GVATGYFFNS ASKVIFDVGL EEYDKVIVTI PEDSVEFYVI
160 170 180 190 200
EGPRIEDVLE KYTELTGKPF LPPMWAFGYM ISRYSYYPQD KVVELVDIMQ
210 220 230 240 250
KEGFRVAGVF LDIHYMDSYK LFTWHPYRFP EPKKLIDELH KRNVKLITIV
260 270 280 290 300
DHGIRVDQNY SPFLSGMGKF CEIESGELFV GKMWPGTTVY PDFFREDTRE
310 320 330 340 350
WWAGLISEWL SQGVDGIWLD MNEPTDFSRA IEIRDVLSSL PVQFRDDRLV
360 370 380 390 400
TTFPDNVVHY LRGKRVKHEK VRNAYPLYEA MATFKGFRTS HRNEIFILSR
410 420 430 440 450
AGYAGIQRYA FIWTGDNTPS WDDLKLQLQL VLGLSISGVP FVGCDIGGFQ
460 470 480 490 500
GRNFAEIDNS MDLLVKYYAL ALFFPFYRSH KATDGIDTEP VFLPDYYKEK
510 520 530 540 550
VKEIVELRYK FLPYIYSLAL EASEKGHPVI RPLFYEFQDD DDMYRIEDEY
560 570 580 590 600
MVGKYLLYAP IVSKEESRLV TLPRGKWYNY WNGEIINGKS VVKSTHELPI
610 620 630 640 650
YLREGSIIPL EGDELIVYGE TSFKRYDNAE ITSSSNEIKF SREIYVSKLT
660 670 680 690
ITSEKPVSKI IVDDSKEIQV EKTMQNTYVA KINQKIRGKI NLE
Length:693
Mass (Da):80,441
Last modified:February 9, 2010 - v1
Checksum:i27BB952C0A7B3858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK43151.1.
PIRiH90486.
RefSeqiWP_009988431.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK43151; AAK43151; SSO3051.
GeneIDi8762439.
KEGGisso:SSO3051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK43151.1.
PIRiH90486.
RefSeqiWP_009988431.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G3MX-ray2.55A/B/C/D/E/F5-693[»]
2G3NX-ray2.55A/B/C/D/E/F5-693[»]
ProteinModelPortaliP0CD66.
SMRiP0CD66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO3051.

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK43151; AAK43151; SSO3051.
GeneIDi8762439.
KEGGisso:SSO3051.

Phylogenomic databases

eggNOGiarCOG03663. Archaea.
COG1501. LUCA.
HOGENOMiHOG000033867.
InParanoidiP0CD66.
KOiK01187.
OMAiFTETNDC.

Enzyme and pathway databases

BRENDAi3.2.1.20. 6163.

Miscellaneous databases

EvolutionaryTraceiP0CD66.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR030458. Glyco_hydro_31_AS.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGLU_SULSO
AccessioniPrimary (citable) accession number: P0CD66
Secondary accession number(s): O59645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: November 2, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.