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P0CD66

- AGLU_SULSO

UniProt

P0CD66 - AGLU_SULSO

Protein

Alpha-glucosidase

Gene

malA

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    Major soluble alpha-glucosidase.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei320 – 3201By similarity
    Active sitei323 – 3231By similarity
    Active sitei416 – 4161Proton donorBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. maltose alpha-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-2839-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-glucosidase (EC:3.2.1.20)
    Alternative name(s):
    Maltase
    Gene namesi
    Name:malA
    Ordered Locus Names:SSO3051
    ORF Names:C23_036
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 693693Alpha-glucosidasePRO_0000185367Add
    BLAST

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 84
    Beta strandi10 – 1910
    Helixi38 – 414
    Beta strandi43 – 486
    Beta strandi51 – 577
    Beta strandi63 – 664
    Beta strandi78 – 836
    Beta strandi99 – 1013
    Beta strandi104 – 1096
    Beta strandi112 – 1187
    Beta strandi124 – 1329
    Beta strandi135 – 1439
    Beta strandi145 – 1517
    Helixi155 – 16612
    Helixi174 – 1774
    Beta strandi178 – 1825
    Helixi189 – 20113
    Beta strandi206 – 2116
    Helixi213 – 2153
    Turni226 – 2283
    Helixi232 – 24110
    Beta strandi245 – 2506
    Helixi261 – 2666
    Beta strandi276 – 2783
    Beta strandi280 – 2834
    Beta strandi286 – 2894
    Helixi296 – 31015
    Turni311 – 3133
    Beta strandi316 – 3194
    Turni322 – 3243
    Helixi328 – 33710
    Helixi348 – 3514
    Beta strandi357 – 3615
    Beta strandi364 – 3674
    Helixi368 – 3714
    Helixi372 – 3743
    Helixi375 – 38915
    Beta strandi397 – 4004
    Helixi406 – 4083
    Beta strandi411 – 4133
    Helixi421 – 43515
    Turni436 – 4383
    Beta strandi441 – 4433
    Beta strandi452 – 4554
    Helixi461 – 47010
    Turni471 – 4733
    Beta strandi477 – 4793
    Helixi490 – 4923
    Helixi495 – 52531
    Beta strandi529 – 5313
    Helixi533 – 5364
    Helixi541 – 5455
    Beta strandi550 – 5523
    Turni553 – 5553
    Beta strandi556 – 5583
    Beta strandi563 – 5675
    Beta strandi569 – 5724
    Beta strandi574 – 5796
    Turni580 – 5823
    Beta strandi585 – 5939
    Beta strandi596 – 5983
    Beta strandi600 – 61011
    Helixi611 – 6133
    Beta strandi614 – 62411
    Beta strandi630 – 6334
    Beta strandi635 – 6428
    Beta strandi644 – 6529
    Beta strandi659 – 6624
    Beta strandi667 – 6693
    Beta strandi671 – 6744
    Beta strandi677 – 69317

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2G3MX-ray2.55A/B/C/D/E/F5-693[»]
    2G3NX-ray2.55A/B/C/D/E/F5-693[»]
    ProteinModelPortaliP0CD66.
    SMRiP0CD66. Positions 4-693.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0CD66.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 31 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000033867.
    KOiK01187.
    OMAiIIMKQAG.

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    InterProiIPR013785. Aldolase_TIM.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR000322. Glyco_hydro_31.
    IPR025887. Glyco_hydro_31_N_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF13802. Gal_mutarotas_2. 1 hit.
    PF01055. Glyco_hydro_31. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 2 hits.
    SSF74650. SSF74650. 1 hit.
    PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CD66-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTIKIYENK GVYKVVIGEP FPPIEFPLEQ KISSNKSLSE LGLTIVQQGN    50
    KVIVEKSLDL KEHIIGLGEK AFELDRKRKR YVMYNVDAGA YKKYQDPLYV 100
    SIPLFISVKD GVATGYFFNS ASKVIFDVGL EEYDKVIVTI PEDSVEFYVI 150
    EGPRIEDVLE KYTELTGKPF LPPMWAFGYM ISRYSYYPQD KVVELVDIMQ 200
    KEGFRVAGVF LDIHYMDSYK LFTWHPYRFP EPKKLIDELH KRNVKLITIV 250
    DHGIRVDQNY SPFLSGMGKF CEIESGELFV GKMWPGTTVY PDFFREDTRE 300
    WWAGLISEWL SQGVDGIWLD MNEPTDFSRA IEIRDVLSSL PVQFRDDRLV 350
    TTFPDNVVHY LRGKRVKHEK VRNAYPLYEA MATFKGFRTS HRNEIFILSR 400
    AGYAGIQRYA FIWTGDNTPS WDDLKLQLQL VLGLSISGVP FVGCDIGGFQ 450
    GRNFAEIDNS MDLLVKYYAL ALFFPFYRSH KATDGIDTEP VFLPDYYKEK 500
    VKEIVELRYK FLPYIYSLAL EASEKGHPVI RPLFYEFQDD DDMYRIEDEY 550
    MVGKYLLYAP IVSKEESRLV TLPRGKWYNY WNGEIINGKS VVKSTHELPI 600
    YLREGSIIPL EGDELIVYGE TSFKRYDNAE ITSSSNEIKF SREIYVSKLT 650
    ITSEKPVSKI IVDDSKEIQV EKTMQNTYVA KINQKIRGKI NLE 693
    Length:693
    Mass (Da):80,441
    Last modified:February 9, 2010 - v1
    Checksum:i27BB952C0A7B3858
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK43151.1.
    PIRiH90486.
    RefSeqiNP_344361.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK43151; AAK43151; SSO3051.
    GeneIDi1453070.
    KEGGisso:SSO3051.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK43151.1 .
    PIRi H90486.
    RefSeqi NP_344361.1. NC_002754.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2G3M X-ray 2.55 A/B/C/D/E/F 5-693 [» ]
    2G3N X-ray 2.55 A/B/C/D/E/F 5-693 [» ]
    ProteinModelPortali P0CD66.
    SMRi P0CD66. Positions 4-693.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK43151 ; AAK43151 ; SSO3051 .
    GeneIDi 1453070.
    KEGGi sso:SSO3051.

    Phylogenomic databases

    HOGENOMi HOG000033867.
    KOi K01187.
    OMAi IIMKQAG.

    Enzyme and pathway databases

    BioCyci SSOL273057:GCH2-2839-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P0CD66.

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    InterProi IPR013785. Aldolase_TIM.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR000322. Glyco_hydro_31.
    IPR025887. Glyco_hydro_31_N_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF13802. Gal_mutarotas_2. 1 hit.
    PF01055. Glyco_hydro_31. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 2 hits.
    SSF74650. SSF74650. 1 hit.
    PROSITEi PS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

    Entry informationi

    Entry nameiAGLU_SULSO
    AccessioniPrimary (citable) accession number: P0CD66
    Secondary accession number(s): O59645
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3