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P0CD66

- AGLU_SULSO

UniProt

P0CD66 - AGLU_SULSO

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Protein

Alpha-glucosidase

Gene
malA, SSO3051, C23_036
Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Major soluble alpha-glucosidase By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei320 – 3201 By similarity
Active sitei323 – 3231 By similarity
Active sitei416 – 4161Proton donor By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-2839-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-glucosidase (EC:3.2.1.20)
Alternative name(s):
Maltase
Gene namesi
Name:malA
Ordered Locus Names:SSO3051
ORF Names:C23_036
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Alpha-glucosidasePRO_0000185367Add
BLAST

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84
Beta strandi10 – 1910
Helixi38 – 414
Beta strandi43 – 486
Beta strandi51 – 577
Beta strandi63 – 664
Beta strandi78 – 836
Beta strandi99 – 1013
Beta strandi104 – 1096
Beta strandi112 – 1187
Beta strandi124 – 1329
Beta strandi135 – 1439
Beta strandi145 – 1517
Helixi155 – 16612
Helixi174 – 1774
Beta strandi178 – 1825
Helixi189 – 20113
Beta strandi206 – 2116
Helixi213 – 2153
Turni226 – 2283
Helixi232 – 24110
Beta strandi245 – 2506
Helixi261 – 2666
Beta strandi276 – 2783
Beta strandi280 – 2834
Beta strandi286 – 2894
Helixi296 – 31015
Turni311 – 3133
Beta strandi316 – 3194
Turni322 – 3243
Helixi328 – 33710
Helixi348 – 3514
Beta strandi357 – 3615
Beta strandi364 – 3674
Helixi368 – 3714
Helixi372 – 3743
Helixi375 – 38915
Beta strandi397 – 4004
Helixi406 – 4083
Beta strandi411 – 4133
Helixi421 – 43515
Turni436 – 4383
Beta strandi441 – 4433
Beta strandi452 – 4554
Helixi461 – 47010
Turni471 – 4733
Beta strandi477 – 4793
Helixi490 – 4923
Helixi495 – 52531
Beta strandi529 – 5313
Helixi533 – 5364
Helixi541 – 5455
Beta strandi550 – 5523
Turni553 – 5553
Beta strandi556 – 5583
Beta strandi563 – 5675
Beta strandi569 – 5724
Beta strandi574 – 5796
Turni580 – 5823
Beta strandi585 – 5939
Beta strandi596 – 5983
Beta strandi600 – 61011
Helixi611 – 6133
Beta strandi614 – 62411
Beta strandi630 – 6334
Beta strandi635 – 6428
Beta strandi644 – 6529
Beta strandi659 – 6624
Beta strandi667 – 6693
Beta strandi671 – 6744
Beta strandi677 – 69317

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G3MX-ray2.55A/B/C/D/E/F5-693[»]
2G3NX-ray2.55A/B/C/D/E/F5-693[»]
ProteinModelPortaliP0CD66.
SMRiP0CD66. Positions 4-693.

Miscellaneous databases

EvolutionaryTraceiP0CD66.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000033867.
KOiK01187.
OMAiIIMKQAG.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CD66-1 [UniParc]FASTAAdd to Basket

« Hide

MQTIKIYENK GVYKVVIGEP FPPIEFPLEQ KISSNKSLSE LGLTIVQQGN    50
KVIVEKSLDL KEHIIGLGEK AFELDRKRKR YVMYNVDAGA YKKYQDPLYV 100
SIPLFISVKD GVATGYFFNS ASKVIFDVGL EEYDKVIVTI PEDSVEFYVI 150
EGPRIEDVLE KYTELTGKPF LPPMWAFGYM ISRYSYYPQD KVVELVDIMQ 200
KEGFRVAGVF LDIHYMDSYK LFTWHPYRFP EPKKLIDELH KRNVKLITIV 250
DHGIRVDQNY SPFLSGMGKF CEIESGELFV GKMWPGTTVY PDFFREDTRE 300
WWAGLISEWL SQGVDGIWLD MNEPTDFSRA IEIRDVLSSL PVQFRDDRLV 350
TTFPDNVVHY LRGKRVKHEK VRNAYPLYEA MATFKGFRTS HRNEIFILSR 400
AGYAGIQRYA FIWTGDNTPS WDDLKLQLQL VLGLSISGVP FVGCDIGGFQ 450
GRNFAEIDNS MDLLVKYYAL ALFFPFYRSH KATDGIDTEP VFLPDYYKEK 500
VKEIVELRYK FLPYIYSLAL EASEKGHPVI RPLFYEFQDD DDMYRIEDEY 550
MVGKYLLYAP IVSKEESRLV TLPRGKWYNY WNGEIINGKS VVKSTHELPI 600
YLREGSIIPL EGDELIVYGE TSFKRYDNAE ITSSSNEIKF SREIYVSKLT 650
ITSEKPVSKI IVDDSKEIQV EKTMQNTYVA KINQKIRGKI NLE 693
Length:693
Mass (Da):80,441
Last modified:February 9, 2010 - v1
Checksum:i27BB952C0A7B3858
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006641 Genomic DNA. Translation: AAK43151.1.
PIRiH90486.
RefSeqiNP_344361.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK43151; AAK43151; SSO3051.
GeneIDi1453070.
KEGGisso:SSO3051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006641 Genomic DNA. Translation: AAK43151.1 .
PIRi H90486.
RefSeqi NP_344361.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2G3M X-ray 2.55 A/B/C/D/E/F 5-693 [» ]
2G3N X-ray 2.55 A/B/C/D/E/F 5-693 [» ]
ProteinModelPortali P0CD66.
SMRi P0CD66. Positions 4-693.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK43151 ; AAK43151 ; SSO3051 .
GeneIDi 1453070.
KEGGi sso:SSO3051.

Phylogenomic databases

HOGENOMi HOG000033867.
KOi K01187.
OMAi IIMKQAG.

Enzyme and pathway databases

BioCyci SSOL273057:GCH2-2839-MONOMER.

Miscellaneous databases

EvolutionaryTracei P0CD66.

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
InterProi IPR013785. Aldolase_TIM.
IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiAGLU_SULSO
AccessioniPrimary (citable) accession number: P0CD66
Secondary accession number(s): O59645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: May 14, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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