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P0CB83 (NDUS7_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
Complex I-20kD
Short name=CI-20kD
NADH-ubiquinone oxidoreductase 20 kDa subunit
Gene names
Name:NDUFS7
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. HAMAP-Rule MF_01356

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01356

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01356

Cofactor

Binds 1 4Fe-4S cluster Potential.

Subunit structure

Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme By similarity.

Subcellular location

Mitochondrion By similarity HAMAP-Rule MF_01356.

Sequence similarities

Belongs to the complex I 20 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3838Mitochondrion By similarity
Chain39 – 213175NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial HAMAP-Rule MF_01356
PRO_0000020029

Sites

Metal binding881Iron-sulfur (4Fe-4S) Potential
Metal binding891Iron-sulfur (4Fe-4S) Potential
Metal binding1531Iron-sulfur (4Fe-4S) Potential
Metal binding1831Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
P0CB83 [UniParc].

Last modified November 24, 2009. Version 1.
Checksum: 79D0276647AFB649

FASTA21323,585
        10         20         30         40         50         60 
MAALSAPGLR SFWILGLRSS VGTAVQAQGV HQSVATDGPS STQPALPKAR AVAPKPSSRG 

        70         80         90        100        110        120 
EYVVAKLDDL INWARRSSLW PMTFGLACCA VEMMHMAAPR YDMDRFGVVF RASPRQSDVM 

       130        140        150        160        170        180 
IVAGTLTNKM APALRKVYDQ MPEPRYVVSM GSCANGGGYY HYSYSVVRGC DRIVPVDIYI 

       190        200        210 
PGCPPTAEAL LYGILQLQRK IKRERRLQIW YRR 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR861249 mRNA. Translation: CAH93318.1.
RefSeqNP_001126953.1. NM_001133481.1.

3D structure databases

ProteinModelPortalP0CB83.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173971.
KEGGpon:100173971.

Organism-specific databases

CTD374291.

Phylogenomic databases

KOK03940.

Family and domain databases

Gene3D3.40.50.700. 1 hit.
HAMAPMF_01356. NDH1_NuoB.
InterProIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view]
PfamPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsTIGR01957. nuoB_fam. 1 hit.
PROSITEPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS7_PONAB
AccessionPrimary (citable) accession number: P0CB83
Secondary accession number(s): Q0MQH8, Q5R4J8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: November 24, 2009
Last modified: February 19, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families