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P0CB75

- PYRF_STRPN

UniProt

P0CB75 - PYRF_STRPN

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111SubstrateUniRule annotation
    Binding sitei34 – 341SubstrateUniRule annotation
    Active sitei63 – 631Proton donorUniRule annotation
    Binding sitei117 – 1171SubstrateUniRule annotation
    Binding sitei179 – 1791SubstrateUniRule annotation
    Binding sitei188 – 1881SubstrateUniRule annotation
    Binding sitei208 – 2081Substrate; via amide nitrogenUniRule annotation
    Binding sitei209 – 2091SubstrateUniRule annotation

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
    3. protein binding Source: IntAct

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciSPNE170187:GHGN-702-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:SP_0701
    OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    Taxonomic identifieri170187 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000585: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233Orotidine 5'-phosphate decarboxylasePRO_0000134587Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-2207109,EBI-2207109
    aroDP635882EBI-2207109,EBI-2207290
    gatAQ97SE62EBI-2207109,EBI-2207039
    gatCQ97SE52EBI-2207109,EBI-2207053
    groSQ97NV32EBI-2207109,EBI-2206949
    purAP658872EBI-2207109,EBI-2206955
    scpAQ97NX53EBI-2207109,EBI-2207368
    uppSQ97SR42EBI-2207109,EBI-2206983

    Protein-protein interaction databases

    IntActiP0CB75. 7 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CB75.
    SMRiP0CB75. Positions 1-229.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni61 – 7010Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226070.
    KOiK01591.
    OMAiRPITQSA.
    OrthoDBiEOG6N6815.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CB75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MREHRPIIAL DFPSFEAVKE FLALFPAEES LYLKVGMELY YAAGPEIVSY    50
    LKGLGHSVFL DLKLHDIPNT VKSAMKILSQ LGVDMTNVHA AGGVEMMKAA 100
    REGLGSQAKL IAVTQLTSTS EAQMQEFQNI QTSLQESVIH YAKKTAEAGL 150
    DGVVCSAQEV QVIKQATNPD FICLTPGIRP AGVAVGDQKR VMTPADAYQI 200
    GSDYIVVGRP ITQAEDPVAA YHAIKDEWTQ DWN 233
    Length:233
    Mass (Da):25,423
    Last modified:November 24, 2009 - v1
    Checksum:i29AB36FBCBF7B4C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK74844.1.
    PIRiC95081.
    RefSeqiNP_345204.1. NC_003028.3.

    Genome annotation databases

    EnsemblBacteriaiAAK74844; AAK74844; SP_0701.
    GeneIDi930651.
    KEGGispn:SP_0701.
    PATRICi19705761. VBIStrPne105772_0727.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK74844.1 .
    PIRi C95081.
    RefSeqi NP_345204.1. NC_003028.3.

    3D structure databases

    ProteinModelPortali P0CB75.
    SMRi P0CB75. Positions 1-229.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P0CB75. 7 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK74844 ; AAK74844 ; SP_0701 .
    GeneIDi 930651.
    KEGGi spn:SP_0701.
    PATRICi 19705761. VBIStrPne105772_0727.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226070.
    KOi K01591.
    OMAi RPITQSA.
    OrthoDBi EOG6N6815.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci SPNE170187:GHGN-702-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-334 / TIGR4.

    Entry informationi

    Entry nameiPYRF_STRPN
    AccessioniPrimary (citable) accession number: P0CB75
    Secondary accession number(s): Q9ZHA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3