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P0CB57

- DDL_STRPN

UniProt

P0CB57 - DDL_STRPN

Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi287 – 2871Magnesium or manganese 1UniRule annotation
    Metal bindingi300 – 3001Magnesium or manganese 1UniRule annotation
    Metal bindingi300 – 3001Magnesium or manganese 2UniRule annotation
    Metal bindingi302 – 3021Magnesium or manganese 2UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi161 – 21656ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPNE170187:GHGN-1678-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
    Alternative name(s):
    D-Ala-D-Ala ligaseUniRule annotation
    D-alanylalanine synthetaseUniRule annotation
    Gene namesi
    Name:ddlUniRule annotation
    Synonyms:ddlA
    Ordered Locus Names:SP_1671
    OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    Taxonomic identifieri170187 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000585: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347D-alanine--D-alanine ligasePRO_0000177887Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0CB57.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini131 – 333203ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1181.
    HOGENOMiHOG000011593.
    KOiK01921.
    OMAiQIDVIFP.
    OrthoDBiEOG64BQ73.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPiMF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CB57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQTIILLYG GRSAEREVSV LSAESVMRAV DYDRFTVKTF FISQSGDFIK    50
    TQEFSHAPGQ EDRLMTNETI DWDKKVAPSA IYEEGAVVFP VLHGPMGEDG 100
    SVQGFLEVLK MPYVGCNILS SSLAMDKITT KRVLESAGIA QVPYVAIVEG 150
    DDVTAKIAEV EEKLAYPVFT KPSNMGSSVG ISKSENQEEL RQALKLAFRY 200
    DSRVLVEQGV NAREIEVGLL GNYDVKSTLP GEVVKDVAFY DYDAKYIDNK 250
    ITMDIPAKIS DDVVAVMRQN AETAFRAIGG LGLSRCDFFY TDKGEIFLNE 300
    LNTMPGFTQW SMYPLLWDNM GISYPKLIER LVDLAKESFD KREAHLI 347
    Length:347
    Mass (Da):38,717
    Last modified:November 3, 2009 - v1
    Checksum:iAFCF7AB1E53F9289
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti250 – 2501K → N in AAK75750. (PubMed:11463916)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK75750.1.
    AJ233887 Genomic DNA. Translation: CAA13580.1.
    Z99894 Genomic DNA. Translation: CAB17019.1.
    Z99837 Genomic DNA. Translation: CAB16962.1.
    Z99844 Genomic DNA. Translation: CAB16969.1.
    Z99845 Genomic DNA. Translation: CAB16970.1.
    Z99878 Genomic DNA. Translation: CAB17003.1.
    Z99893 Genomic DNA. Translation: CAB17018.1.
    AJ232272 Genomic DNA. Translation: CAA13275.1.
    AJ232245 Genomic DNA. Translation: CAA13248.1.
    AJ232254 Genomic DNA. Translation: CAA13257.1.
    AJ232260 Genomic DNA. Translation: CAA13263.1.
    AJ232267 Genomic DNA. Translation: CAA13270.1.
    AJ232268 Genomic DNA. Translation: CAA13271.1.
    PIRiE95194.
    RefSeqiNP_346110.1. NC_003028.3.

    Genome annotation databases

    EnsemblBacteriaiAAK75750; AAK75750; SP_1671.
    GeneIDi931166.
    KEGGispn:SP_1671.
    PATRICi19707777. VBIStrPne105772_1731.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK75750.1 .
    AJ233887 Genomic DNA. Translation: CAA13580.1 .
    Z99894 Genomic DNA. Translation: CAB17019.1 .
    Z99837 Genomic DNA. Translation: CAB16962.1 .
    Z99844 Genomic DNA. Translation: CAB16969.1 .
    Z99845 Genomic DNA. Translation: CAB16970.1 .
    Z99878 Genomic DNA. Translation: CAB17003.1 .
    Z99893 Genomic DNA. Translation: CAB17018.1 .
    AJ232272 Genomic DNA. Translation: CAA13275.1 .
    AJ232245 Genomic DNA. Translation: CAA13248.1 .
    AJ232254 Genomic DNA. Translation: CAA13257.1 .
    AJ232260 Genomic DNA. Translation: CAA13263.1 .
    AJ232267 Genomic DNA. Translation: CAA13270.1 .
    AJ232268 Genomic DNA. Translation: CAA13271.1 .
    PIRi E95194.
    RefSeqi NP_346110.1. NC_003028.3.

    3D structure databases

    ProteinModelPortali P0CB57.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK75750 ; AAK75750 ; SP_1671 .
    GeneIDi 931166.
    KEGGi spn:SP_1671.
    PATRICi 19707777. VBIStrPne105772_1731.

    Phylogenomic databases

    eggNOGi COG1181.
    HOGENOMi HOG000011593.
    KOi K01921.
    OMAi QIDVIFP.
    OrthoDBi EOG64BQ73.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci SPNE170187:GHGN-1678-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPi MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-334 / TIGR4.
    2. "Identification of three major clones of multiply antibiotic resistant Streptococcus pneumoniae in Taiwanese hospitals using multilocus sequence typing."
      Zhi-Yuan S., Enright M.C., Wilkinson P., Spratt B.G.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 155-300.
    3. "Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae."
      Coffey T.J., Enright M.C., Daniels M., Wilkinson P., Berron S., Fenoll A., Spratt B.G.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 155-301.
      Strain: Various strains.
    4. "A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease."
      Enright M.C., Spratt B.G.
      Microbiology 144:3049-3060(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 155-301.
      Strain: Various strains.

    Entry informationi

    Entry nameiDDL_STRPN
    AccessioniPrimary (citable) accession number: P0CB57
    Secondary accession number(s): O54631
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3