Reviewed,
UniProtKB/Swiss-Prot P0CB56 (KAX46_TITST)
Last modified
November 3, 2009.
Version 1.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (2) |
 Third-party data |
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Names and origin
| Protein names | Recommended name: Potassium channel toxin alpha-KTx 4.6 Alternative name(s): Tst26 |
| Organism | Tityus stigmurus (Brazilian scorpion) |
| Taxonomic identifier | 50344 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Tityus |
Protein attributes
| Sequence length | 37 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Blocks potassium channels Kv1.2/KCNA2 and Kv1.3/KCNA3 with high affinity (K(d)=1.9 nM and 10.7 nM, respectively). The voltage-dependent steady-state parameters of potassium channel gating are unaffected by the toxin in both channels, but due to the fast association and dissociation kinetics the toxin slows the rate of inactivation of Kv1.3/KCNA3 channels. Does not affect several other ion channels Kv1.1/KCNA1, Kv1.4/KCNA4, Kv1.5/KCNA5, ERG/KCNH, IKCa1/KCNN4, BK/KCNMA1, Nav1.5/KCNA5. Ref.1 |
| Subcellular location | |
| Tissue specificity | Expressed by the venom gland. Ref.1 |
| Sequence similarities | Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 4 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Molecular function | Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin |
| PTM | Disulfide bond |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
Sequences
References
| [1] | "Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus." Papp F., Batista C.V., Varga Z., Herceg M., Roman-Gonzalez S.A., Gaspar R., Possani L.D., Panyi G. Toxicon 54:379-389(2009) [PubMed: 19500613] [Abstract] Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Venom. |
Cross-references
Entry information
| Entry name | KAX46_TITST | ||||||||
| Accession | Primary (citable) accession number: P0CB56 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Tox-Prot (Toxin Annotation Project) | ||||||||
Relevant documents
| Scorpion potassium channel toxins Nomenclature of scorpion potassium channel toxins and list of entries |
| SIMILARITY comments Index of protein domains and families |
