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P0CB56

- KAX46_TITST

UniProt

P0CB56 - KAX46_TITST

Protein

Potassium channel toxin alpha-KTx 4.6

Gene
N/A
Organism
Tityus stigmurus (Brazilian scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Blocks potassium channels Kv1.2/KCNA2 and Kv1.3/KCNA3 with high affinity (K(d)=1.9 nM and 10.7 nM, respectively). The voltage-dependent steady-state parameters of potassium channel gating are unaffected by the toxin in both channels, but due to the fast association and dissociation kinetics the toxin slows the rate of inactivation of Kv1.3/KCNA3 channels.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei27 – 271Basic residue of the functional dyadBy similarity
    Sitei36 – 361Aromatic residue of the functional dyadBy similarity

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. defense response Source: InterPro
    2. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 4.6
    Alternative name(s):
    Tst26
    OrganismiTityus stigmurus (Brazilian scorpion)
    Taxonomic identifieri50344 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3737Potassium channel toxin alpha-KTx 4.6PRO_0000388240Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi7 ↔ 28By similarity
    Disulfide bondi13 ↔ 33By similarity
    Disulfide bondi17 ↔ 35By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.30.30.10. 1 hit.
    InterProiIPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view]
    PfamiPF00451. Toxin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00286. CHARYBDTOXIN.
    ProDomiPD003586. Scorpion_toxinS. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF57095. SSF57095. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0CB56-1 [UniParc]FASTAAdd to Basket

    « Hide

    VFINAKCRGS PECLPKCKQA IGKAAGKCMN GKCKCYP                 37
    Length:37
    Mass (Da):3,947
    Last modified:November 3, 2009 - v1
    Checksum:i639B8273B7335929
    GO

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.30.10. 1 hit.
    InterProi IPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view ]
    Pfami PF00451. Toxin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00286. CHARYBDTOXIN.
    ProDomi PD003586. Scorpion_toxinS. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus."
      Papp F., Batista C.V., Varga Z., Herceg M., Roman-Gonzalez S.A., Gaspar R., Possani L.D., Panyi G.
      Toxicon 54:379-389(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Venom.

    Entry informationi

    Entry nameiKAX46_TITST
    AccessioniPrimary (citable) accession number: P0CB56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    This toxin has no effects on Kv1.1/KCNA1, Kv1.4/KCNA4, Kv1.5/KCNA5, Kv11.1/KCNH2, KCa3.1/KCNN4, BK/KCNMA1, and Nav1.5/KCNA5.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3