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P0CB46

- CASPG_HUMAN

UniProt

P0CB46 - CASPG_HUMAN

Protein

Putative caspase-16

Gene

CASP16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei3 – 31By similarity
    Active sitei45 – 451By similarity

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: RefGenome

    GO - Biological processi

    1. extrinsic apoptotic signaling pathway in absence of ligand Source: RefGenome
    2. intrinsic apoptotic signaling pathway in response to DNA damage Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative caspase-16 (EC:3.4.22.-)
    Gene namesi
    Name:CASP16
    Synonyms:CASP14L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:27290. CASP16.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183Putative caspase-16PRO_0000386595Add
    BLAST

    Proteomic databases

    PaxDbiP0CB46.
    PRIDEiP0CB46.

    Expressioni

    Gene expression databases

    BgeeiP0CB46.
    GenevestigatoriP0CB46.

    Organism-specific databases

    HPAiHPA062836.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CB46.
    SMRiP0CB46. Positions 17-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C14A family.Curated

    Phylogenomic databases

    eggNOGiNOG278541.
    HOGENOMiHOG000231878.
    OMAiDTCRGPV.
    OrthoDBiEOG7SR4MS.
    PhylomeDBiP0CB46.

    Family and domain databases

    Gene3Di3.40.50.1460. 1 hit.
    InterProiIPR029030. Caspase-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR002138. Pept_C14_p10.
    [Graphical view]
    PfamiPF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    PROSITEiPS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CB46-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHGGPRGQL LGADGQEVQP EALMQELSRC QVLQGRPKIF LLQACRGGNR    50
    DAGVGPTALP WYWSWLRAPP SVPSHADVLQ IYAEAQGSSC RGTPPGSSDQ 100
    ADILTVYSAA EGYVAYRDDK GSDFIQTLVE VLRANPGRDL LELLTEVNRR 150
    VCEQEVLGPD CDELRKACLE IRSSLRRRLC LQA 183
    Length:183
    Mass (Da):20,061
    Last modified:October 13, 2009 - v1
    Checksum:i75DB191014377E7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098666 mRNA. No translation available.
    AC108134 Genomic DNA. No translation available.
    BC111724 mRNA. No translation available.
    UniGeneiHs.434132.

    Genome annotation databases

    EnsembliENST00000428155; ENSP00000400592; ENSG00000228146.
    UCSCiuc002cuf.1. human.

    Polymorphism databases

    DMDMi261263118.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098666 mRNA. No translation available.
    AC108134 Genomic DNA. No translation available.
    BC111724 mRNA. No translation available.
    UniGenei Hs.434132.

    3D structure databases

    ProteinModelPortali P0CB46.
    SMRi P0CB46. Positions 17-179.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 261263118.

    Proteomic databases

    PaxDbi P0CB46.
    PRIDEi P0CB46.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000428155 ; ENSP00000400592 ; ENSG00000228146 .
    UCSCi uc002cuf.1. human.

    Organism-specific databases

    GeneCardsi GC16P003198.
    HGNCi HGNC:27290. CASP16.
    HPAi HPA062836.
    neXtProti NX_P0CB46.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278541.
    HOGENOMi HOG000231878.
    OMAi DTCRGPV.
    OrthoDBi EOG7SR4MS.
    PhylomeDBi P0CB46.

    Miscellaneous databases

    NextBioi 89656.

    Gene expression databases

    Bgeei P0CB46.
    Genevestigatori P0CB46.

    Family and domain databases

    Gene3Di 3.40.50.1460. 1 hit.
    InterProi IPR029030. Caspase-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR002138. Pept_C14_p10.
    [Graphical view ]
    Pfami PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    PROSITEi PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3."
      Centola M., Chen X., Sood R., Deng Z., Aksentijevich I., Blake T., Ricke D.O., Chen X., Wood G., Zaks N., Richards N., Krizman D., Mansfield E., Apostolou S., Liu J., Shafran N., Vedula A., Hamon M.
      , Cercek A., Kahan T., Gumucio D., Callen D.F., Richards R.I., Moyzis R.K., Dogget N.A., Collins F.S., Liu P.P., Fischel-Ghodsian N., Kastner D.L.
      Genome Res. 8:1172-1191(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire."
      Eckhart L., Ballaun C., Hermann M., VandeBerg J.L., Sipos W., Uthman A., Fischer H., Tschachler E.
      Mol. Biol. Evol. 25:831-841(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCASPG_HUMAN
    AccessioniPrimary (citable) accession number: P0CB46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3