P0CB46 (CASPG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative caspase-16
EC=3.4.22.-

Gene names

Name:	CASP16
Synonyms:	CASP14L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Sequence similarities	Belongs to the peptidase C14A family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 183	183	Putative caspase-16		PRO_0000386595
Sites
	Active site	3	1	By similarity
	Active site	45	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0CB46 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: 75DB191014377E7B	FASTA	183	20,061
	10 20 30 40 50 60 MAHGGPRGQL LGADGQEVQP EALMQELSRC QVLQGRPKIF LLQACRGGNR DAGVGPTALP 70 80 90 100 110 120 WYWSWLRAPP SVPSHADVLQ IYAEAQGSSC RGTPPGSSDQ ADILTVYSAA EGYVAYRDDK 130 140 150 160 170 180 GSDFIQTLVE VLRANPGRDL LELLTEVNRR VCEQEVLGPD CDELRKACLE IRSSLRRRLC LQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3." Centola M., Chen X., Sood R., Deng Z., Aksentijevich I., Blake T., Ricke D.O., Chen X., Wood G., Zaks N., Richards N., Krizman D., Mansfield E., Apostolou S., Liu J., Shafran N., Vedula A., Hamon M. , Cercek A., Kahan T., Gumucio D., Callen D.F., Richards R.I., Moyzis R.K., Dogget N.A., Collins F.S., Liu P.P., Fischel-Ghodsian N., Kastner D.L. Genome Res. 8:1172-1191(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire." Eckhart L., Ballaun C., Hermann M., VandeBerg J.L., Sipos W., Uthman A., Fischer H., Tschachler E. Mol. Biol. Evol. 25:831-841(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF098666 mRNA. No translation available. AC108134 Genomic DNA. No translation available. BC111724 mRNA. No translation available.
IPI	IPI00888838.
RefSeq	XP_003403507.1. XM_003403459.1. XP_003403727.1. XM_003403679.1. XP_003960647.1. XM_003960598.1.
UniGene	Hs.434132.
3D structure databases
ProteinModelPortal	P0CB46.
ModBase	Search...
Polymorphism databases
DMDM	261263118.
Proteomic databases
PaxDb	P0CB46.
PRIDE	P0CB46.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000428155; ENSP00000400592; ENSG00000228146.
GeneID	197350.
KEGG	hsa:197350.
UCSC	uc002cuf.1. human.
Organism-specific databases
CTD	197350.
GeneCards	GC16P003198.
HGNC	HGNC:27290. CASP16.
neXtProt	NX_P0CB46.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG278541.
HOGENOM	HOG000231878.
OrthoDB	EOG4WSWB9.
Gene expression databases
Bgee	P0CB46.
Genevestigator	P0CB46.
Family and domain databases
InterPro	IPR011600. Pept_C14_cat. IPR001309. Pept_C14_ICE_p20. IPR002138. Pept_C14_p10. IPR002398. Pept_C14_p45. [Graphical view]
PANTHER	PTHR10454. PTHR10454. 1 hit.
Pfam	PF00656. Peptidase_C14. 1 hit. [Graphical view]
PROSITE	PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	197350.
NextBio	89656.

Entry information

Entry name

CASPG_HUMAN

Accession

Primary (citable) accession number: P0CB46

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.