Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0CB46 (CASPG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative caspase-16

EC=3.4.22.-
Gene names
Name:CASP16
Synonyms:CASP14L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Sequence similarities

Belongs to the peptidase C14A family.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 183183Putative caspase-16
PRO_0000386595

Sites

Active site31 By similarity
Active site451 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0CB46 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 75DB191014377E7B

FASTA18320,061
        10         20         30         40         50         60 
MAHGGPRGQL LGADGQEVQP EALMQELSRC QVLQGRPKIF LLQACRGGNR DAGVGPTALP 

        70         80         90        100        110        120 
WYWSWLRAPP SVPSHADVLQ IYAEAQGSSC RGTPPGSSDQ ADILTVYSAA EGYVAYRDDK 

       130        140        150        160        170        180 
GSDFIQTLVE VLRANPGRDL LELLTEVNRR VCEQEVLGPD CDELRKACLE IRSSLRRRLC 


LQA 

« Hide

References

« Hide 'large scale' references
[1]"Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3."
Centola M., Chen X., Sood R., Deng Z., Aksentijevich I., Blake T., Ricke D.O., Chen X., Wood G., Zaks N., Richards N., Krizman D., Mansfield E., Apostolou S., Liu J., Shafran N., Vedula A., Hamon M. expand/collapse author list , Cercek A., Kahan T., Gumucio D., Callen D.F., Richards R.I., Moyzis R.K., Dogget N.A., Collins F.S., Liu P.P., Fischel-Ghodsian N., Kastner D.L.
Genome Res. 8:1172-1191(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire."
Eckhart L., Ballaun C., Hermann M., VandeBerg J.L., Sipos W., Uthman A., Fischer H., Tschachler E.
Mol. Biol. Evol. 25:831-841(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF098666 mRNA. No translation available.
AC108134 Genomic DNA. No translation available.
BC111724 mRNA. No translation available.
UniGeneHs.434132.

3D structure databases

ProteinModelPortalP0CB46.
SMRP0CB46. Positions 1-179.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM261263118.

Proteomic databases

PaxDbP0CB46.
PRIDEP0CB46.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000428155; ENSP00000400592; ENSG00000228146.
UCSCuc002cuf.1. human.

Organism-specific databases

GeneCardsGC16P003198.
HGNCHGNC:27290. CASP16.
HPAHPA062836.
neXtProtNX_P0CB46.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278541.
HOGENOMHOG000231878.
OMAELSHCRA.
OrthoDBEOG7SR4MS.

Gene expression databases

BgeeP0CB46.
GenevestigatorP0CB46.

Family and domain databases

InterProIPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR002138. Pept_C14_p10.
[Graphical view]
PfamPF00656. Peptidase_C14. 1 hit.
[Graphical view]
PROSITEPS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi197350.
NextBio89656.

Entry information

Entry nameCASPG_HUMAN
AccessionPrimary (citable) accession number: P0CB46
Entry history
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM