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P0CB46

- CASPG_HUMAN

UniProt

P0CB46 - CASPG_HUMAN

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Protein

Putative caspase-16

Gene

CASP16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei3 – 31By similarity
Active sitei45 – 451By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. extrinsic apoptotic signaling pathway in absence of ligand Source: RefGenome
  2. intrinsic apoptotic signaling pathway in response to DNA damage Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Putative caspase-16 (EC:3.4.22.-)
Gene namesi
Name:CASP16
Synonyms:CASP14L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:27290. CASP16.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Putative caspase-16PRO_0000386595Add
BLAST

Proteomic databases

PaxDbiP0CB46.
PRIDEiP0CB46.

Expressioni

Gene expression databases

BgeeiP0CB46.
GenevestigatoriP0CB46.

Organism-specific databases

HPAiHPA062836.

Structurei

3D structure databases

ProteinModelPortaliP0CB46.
SMRiP0CB46. Positions 17-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

eggNOGiNOG278541.
GeneTreeiENSGT00760000118912.
HOGENOMiHOG000231878.
InParanoidiP0CB46.
OMAiDTCRGPV.
OrthoDBiEOG7SR4MS.
PhylomeDBiP0CB46.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR002138. Pept_C14_p10.
[Graphical view]
PfamiPF00656. Peptidase_C14. 1 hit.
[Graphical view]
PROSITEiPS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CB46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHGGPRGQL LGADGQEVQP EALMQELSRC QVLQGRPKIF LLQACRGGNR
60 70 80 90 100
DAGVGPTALP WYWSWLRAPP SVPSHADVLQ IYAEAQGSSC RGTPPGSSDQ
110 120 130 140 150
ADILTVYSAA EGYVAYRDDK GSDFIQTLVE VLRANPGRDL LELLTEVNRR
160 170 180
VCEQEVLGPD CDELRKACLE IRSSLRRRLC LQA
Length:183
Mass (Da):20,061
Last modified:October 13, 2009 - v1
Checksum:i75DB191014377E7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF098666 mRNA. No translation available.
AC108134 Genomic DNA. No translation available.
BC111724 mRNA. No translation available.
UniGeneiHs.434132.

Genome annotation databases

EnsembliENST00000428155; ENSP00000400592; ENSG00000228146.
UCSCiuc002cuf.1. human.

Polymorphism databases

DMDMi261263118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF098666 mRNA. No translation available.
AC108134 Genomic DNA. No translation available.
BC111724 mRNA. No translation available.
UniGenei Hs.434132.

3D structure databases

ProteinModelPortali P0CB46.
SMRi P0CB46. Positions 17-179.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 261263118.

Proteomic databases

PaxDbi P0CB46.
PRIDEi P0CB46.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000428155 ; ENSP00000400592 ; ENSG00000228146 .
UCSCi uc002cuf.1. human.

Organism-specific databases

GeneCardsi GC16P003198.
HGNCi HGNC:27290. CASP16.
HPAi HPA062836.
neXtProti NX_P0CB46.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278541.
GeneTreei ENSGT00760000118912.
HOGENOMi HOG000231878.
InParanoidi P0CB46.
OMAi DTCRGPV.
OrthoDBi EOG7SR4MS.
PhylomeDBi P0CB46.

Miscellaneous databases

NextBioi 89656.

Gene expression databases

Bgeei P0CB46.
Genevestigatori P0CB46.

Family and domain databases

Gene3Di 3.40.50.1460. 1 hit.
InterProi IPR029030. Caspase-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR002138. Pept_C14_p10.
[Graphical view ]
Pfami PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PROSITEi PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3."
    Centola M., Chen X., Sood R., Deng Z., Aksentijevich I., Blake T., Ricke D.O., Chen X., Wood G., Zaks N., Richards N., Krizman D., Mansfield E., Apostolou S., Liu J., Shafran N., Vedula A., Hamon M.
    , Cercek A., Kahan T., Gumucio D., Callen D.F., Richards R.I., Moyzis R.K., Dogget N.A., Collins F.S., Liu P.P., Fischel-Ghodsian N., Kastner D.L.
    Genome Res. 8:1172-1191(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire."
    Eckhart L., Ballaun C., Hermann M., VandeBerg J.L., Sipos W., Uthman A., Fischer H., Tschachler E.
    Mol. Biol. Evol. 25:831-841(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCASPG_HUMAN
AccessioniPrimary (citable) accession number: P0CB46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: October 13, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3