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P0CB43

- F203B_HUMAN

UniProt

P0CB43 - F203B_HUMAN

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Protein
Protein FAM203B
Gene
FAM203B, BRP16L, C8orf30B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM203B
Alternative name(s):
Brain protein 16-like
Gene namesi
Name:FAM203B
Synonyms:BRP16L, C8orf30B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:32323. FAM203B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672349.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 390389Protein FAM203B
PRO_0000386454Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine1 Publication
Modified residuei388 – 3881Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP0CB43.
PRIDEiP0CB43.

PTM databases

PhosphoSiteiP0CB43.

Expressioni

Gene expression databases

BgeeiP0CB43.
GenevestigatoriP0CB43.

Organism-specific databases

HPAiHPA042470.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366623.

Structurei

3D structure databases

ProteinModelPortaliP0CB43.
SMRiP0CB43. Positions 22-233, 286-312.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 151148Ala-rich
Add
BLAST

Sequence similaritiesi

Belongs to the FAM203 family.

Phylogenomic databases

eggNOGiNOG304399.
OMAiMHESLAN.
OrthoDBiEOG7D59NH.
PhylomeDBiP0CB43.
TreeFamiTF313296.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR007206. FAM203_C.
IPR007205. FAM203_N.
[Graphical view]
PfamiPF04063. DUF383. 1 hit.
PF04064. DUF384. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CB43-1 [UniParc]FASTAAdd to Basket

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MGEAGAGAGA SGGPEASPEA EVVKLLPFLA PGARADLQAA AVRHVLALTG    50
CGPGRALLAG QAALLQALME LAPASAPARD AARALVNLAA DPGLHETLLA 100
ADPGLPARLM GRALDPQWPW AEEAAAALAN LSREPAPCAA LMAALAAAEP 150
ADSGLERLVR ALCTPGYNAR APLHYLAPLL SNLSQRPAAR AFLLDPDRCV 200
VQRLLPLTQY PDSSVRRGGV VGTLRNCCFE HRHHEWLLGP EVDILPFLLL 250
PLAGPEDFSE EEMQRLPVDL QYLPPDKQRE PDADIRKMLV EAIMLLTATA 300
PGRQQVRDQG AYLILRELHS WEPEPDVRTA CEKLIQVLIG DEPERGMENL 350
LEVQVPEDVE QQLQQLDCRE QEQLERELAP EPWVERATPT 390
Length:390
Mass (Da):42,128
Last modified:October 13, 2009 - v1
Checksum:iC1FAA4E933637FDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC110280 Genomic DNA. No translation available.
UniGeneiHs.300224.

Genome annotation databases

EnsembliENST00000377406; ENSP00000366623; ENSG00000230567.

Polymorphism databases

DMDMi261263117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC110280 Genomic DNA. No translation available.
UniGenei Hs.300224.

3D structure databases

ProteinModelPortali P0CB43.
SMRi P0CB43. Positions 22-233, 286-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000366623.

PTM databases

PhosphoSitei P0CB43.

Polymorphism databases

DMDMi 261263117.

Proteomic databases

PaxDbi P0CB43.
PRIDEi P0CB43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377406 ; ENSP00000366623 ; ENSG00000230567 .

Organism-specific databases

GeneCardsi GC08P145437.
HGNCi HGNC:32323. FAM203B.
HPAi HPA042470.
neXtProti NX_P0CB43.
PharmGKBi PA142672349.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304399.
OMAi MHESLAN.
OrthoDBi EOG7D59NH.
PhylomeDBi P0CB43.
TreeFami TF313296.

Miscellaneous databases

NextBioi 126033.
PROi P0CB43.

Gene expression databases

Bgeei P0CB43.
Genevestigatori P0CB43.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR007206. FAM203_C.
IPR007205. FAM203_N.
[Graphical view ]
Pfami PF04063. DUF383. 1 hit.
PF04064. DUF384. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-388, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF203B_HUMAN
AccessioniPrimary (citable) accession number: P0CB43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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