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Protein

Phosphoethanolamine transferase EptC

Gene

eptC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core.By similarity

Pathwayi: LPS core biosynthesis

This protein is involved in the pathway LPS core biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway LPS core biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

  • phosphotransferase activity, phosphate group as acceptor Source: EcoCyc
  • sulfuric ester hydrolase activity Source: InterPro

GO - Biological processi

  • lipopolysaccharide core region biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:EG11914-MONOMER
MetaCyc:EG11914-MONOMER
UniPathwayiUPA00958

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoethanolamine transferase EptC (EC:2.7.-.-)
Gene namesi
Name:eptC
Synonyms:cptA, yijP
Ordered Locus Names:b3955, JW3927
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11914 eptC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002091501 – 577Phosphoethanolamine transferase EptCAdd BLAST577

Proteomic databases

EPDiP0CB39
PaxDbiP0CB39
PRIDEiP0CB39

Interactioni

Subunit structurei

Forms a complex with an unidentified protein of approximately 36 kDa.1 Publication

Protein-protein interaction databases

BioGridi4260945, 16 interactors
IntActiP0CB39, 2 interactors
STRINGi316385.ECDH10B_4143

Structurei

3D structure databases

ProteinModelPortaliP0CB39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DIJ Bacteria
COG2194 LUCA
HOGENOMiHOG000126729
InParanoidiP0CB39
KOiK19353
OMAiMEPAVPW
PhylomeDBiP0CB39

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR012549 EptA-like_N
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF08019 DUF1705, 1 hit
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit

Sequencei

Sequence statusi: Complete.

P0CB39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSTEVQAKP LFSWKALGWA LLYFWFFSTL LQAIIYISGY SGTNGIRDSL
60 70 80 90 100
LFSSLWLIPV FLFPKRIKII AAVIGVVLWA ASLAALCYYV IYGQEFSQSV
110 120 130 140 150
LFVMFETNTN EASEYLSQYF SLKIVLIALA YTAVAVLLWT RLRPVYIPKP
160 170 180 190 200
WRYVVSFALL YGLILHPIAM NTFIKNKPFE KTLDNLASRM EPAAPWQFLT
210 220 230 240 250
GYYQYRQQLN SLTKLLNENN ALPPLANFKD ESGNEPRTLV LVIGESTQRG
260 270 280 290 300
RMSLYGYPRE TTPELDALHK TDPNLTVFNN VVTSRPYTIE ILQQALTFAN
310 320 330 340 350
EKNPDLYLTQ PSLMNMMKQA GYKTFWITNQ QTMTARNTML TVFSRQTDKQ
360 370 380 390 400
YYMNQQRTQS AREYDTNVLK PFQEVLNDPA PKKLIIVHLL GTHIKYKYRY
410 420 430 440 450
PENQGKFDGN TDHVPPGLNA EELESYNDYD NANLYNDHVV ASLIKDFKAA
460 470 480 490 500
NPNGFLVYFS DHGEEVYDTP PHKTQGRNED NPTRHMYTIP FLLWTSEKWQ
510 520 530 540 550
ATHPRDFSQD VDRKYSLAEL IHTWSDLAGL SYDGYDPTRS VVNPQFKETT
560 570
RWIGNPYKKN ALIDYDTLPY GDQVGNQ
Length:577
Mass (Da):66,610
Last modified:September 22, 2009 - v1
Checksum:i08465655D87CF75A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA Translation: AAC43061.1
U00096 Genomic DNA Translation: AAC76937.1
AP009048 Genomic DNA Translation: BAE77356.1
PIRiF65202
RefSeqiNP_418390.1, NC_000913.3
WP_000556306.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76937; AAC76937; b3955
BAE77356; BAE77356; BAE77356
GeneIDi948458
KEGGiecj:JW3927
eco:b3955
PATRICifig|1411691.4.peg.2750

Similar proteinsi

Entry informationi

Entry nameiEPTC_ECOLI
AccessioniPrimary (citable) accession number: P0CB39
Secondary accession number(s): P32678, Q2M8Q0, Q9S4U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health