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Protein

Phosphoethanolamine transferase EptC

Gene

eptC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core.By similarity

Pathwayi: LPS core biosynthesis

This protein is involved in the pathway LPS core biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway LPS core biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

  • phosphotransferase activity, phosphate group as acceptor Source: EcoCyc
  • sulfuric ester hydrolase activity Source: InterPro

GO - Biological processi

  • lipopolysaccharide core region biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:EG11914-MONOMER.
MetaCyc:EG11914-MONOMER.
UniPathwayiUPA00958.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoethanolamine transferase EptC (EC:2.7.-.-)
Gene namesi
Name:eptC
Synonyms:cptA, yijP
Ordered Locus Names:b3955, JW3927
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11914. eptC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Phosphoethanolamine transferase EptCPRO_0000209150Add
BLAST

Proteomic databases

EPDiP0CB39.
PaxDbiP0CB39.
PRIDEiP0CB39.

Interactioni

Subunit structurei

Forms a complex with an unidentified protein of approximately 36 kDa.1 Publication

Protein-protein interaction databases

BioGridi4260945. 9 interactions.
IntActiP0CB39. 2 interactions.
STRINGi511145.b3955.

Structurei

3D structure databases

ProteinModelPortaliP0CB39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DIJ. Bacteria.
COG2194. LUCA.
HOGENOMiHOG000126729.
InParanoidiP0CB39.
KOiK19353.
OMAiMEPAVPW.
PhylomeDBiP0CB39.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR012549. DUF1705.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF08019. DUF1705. 1 hit.
PF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CB39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSTEVQAKP LFSWKALGWA LLYFWFFSTL LQAIIYISGY SGTNGIRDSL
60 70 80 90 100
LFSSLWLIPV FLFPKRIKII AAVIGVVLWA ASLAALCYYV IYGQEFSQSV
110 120 130 140 150
LFVMFETNTN EASEYLSQYF SLKIVLIALA YTAVAVLLWT RLRPVYIPKP
160 170 180 190 200
WRYVVSFALL YGLILHPIAM NTFIKNKPFE KTLDNLASRM EPAAPWQFLT
210 220 230 240 250
GYYQYRQQLN SLTKLLNENN ALPPLANFKD ESGNEPRTLV LVIGESTQRG
260 270 280 290 300
RMSLYGYPRE TTPELDALHK TDPNLTVFNN VVTSRPYTIE ILQQALTFAN
310 320 330 340 350
EKNPDLYLTQ PSLMNMMKQA GYKTFWITNQ QTMTARNTML TVFSRQTDKQ
360 370 380 390 400
YYMNQQRTQS AREYDTNVLK PFQEVLNDPA PKKLIIVHLL GTHIKYKYRY
410 420 430 440 450
PENQGKFDGN TDHVPPGLNA EELESYNDYD NANLYNDHVV ASLIKDFKAA
460 470 480 490 500
NPNGFLVYFS DHGEEVYDTP PHKTQGRNED NPTRHMYTIP FLLWTSEKWQ
510 520 530 540 550
ATHPRDFSQD VDRKYSLAEL IHTWSDLAGL SYDGYDPTRS VVNPQFKETT
560 570
RWIGNPYKKN ALIDYDTLPY GDQVGNQ
Length:577
Mass (Da):66,610
Last modified:September 22, 2009 - v1
Checksum:i08465655D87CF75A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43061.1.
U00096 Genomic DNA. Translation: AAC76937.1.
AP009048 Genomic DNA. Translation: BAE77356.1.
PIRiF65202.
RefSeqiNP_418390.1. NC_000913.3.
WP_000556306.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76937; AAC76937; b3955.
BAE77356; BAE77356; BAE77356.
GeneIDi948458.
KEGGiecj:JW3927.
eco:b3955.
PATRICi32123431. VBIEscCol129921_4076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43061.1.
U00096 Genomic DNA. Translation: AAC76937.1.
AP009048 Genomic DNA. Translation: BAE77356.1.
PIRiF65202.
RefSeqiNP_418390.1. NC_000913.3.
WP_000556306.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0CB39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260945. 9 interactions.
IntActiP0CB39. 2 interactions.
STRINGi511145.b3955.

Proteomic databases

EPDiP0CB39.
PaxDbiP0CB39.
PRIDEiP0CB39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76937; AAC76937; b3955.
BAE77356; BAE77356; BAE77356.
GeneIDi948458.
KEGGiecj:JW3927.
eco:b3955.
PATRICi32123431. VBIEscCol129921_4076.

Organism-specific databases

EchoBASEiEB1858.
EcoGeneiEG11914. eptC.

Phylogenomic databases

eggNOGiENOG4105DIJ. Bacteria.
COG2194. LUCA.
HOGENOMiHOG000126729.
InParanoidiP0CB39.
KOiK19353.
OMAiMEPAVPW.
PhylomeDBiP0CB39.

Enzyme and pathway databases

UniPathwayiUPA00958.
BioCyciEcoCyc:EG11914-MONOMER.
MetaCyc:EG11914-MONOMER.

Miscellaneous databases

PROiP0CB39.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR012549. DUF1705.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF08019. DUF1705. 1 hit.
PF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEPTC_ECOLI
AccessioniPrimary (citable) accession number: P0CB39
Secondary accession number(s): P32678, Q2M8Q0, Q9S4U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: September 7, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.