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Protein

Putative zinc finger protein 735

Gene

ZNF735

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri157 – 17923C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri185 – 20723C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 23523C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 735
Alternative name(s):
Zinc finger protein 735 pseudogene
Gene namesi
Name:ZNF735
Synonyms:ZNF735P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:32466. ZNF735.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410268.

Polymorphism and mutation databases

BioMutaiZNF735.
DMDMi259710468.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Putative zinc finger protein 735PRO_0000383475Add
BLAST

Proteomic databases

EPDiP0CB33.
PeptideAtlasiP0CB33.
PRIDEiP0CB33.

PTM databases

iPTMnetiP0CB33.
PhosphoSiteiP0CB33.

Structurei

3D structure databases

ProteinModelPortaliP0CB33.
SMRiP0CB33. Positions 155-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 8772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri157 – 17923C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri185 – 20723C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 23523C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00790000122969.
HOVERGENiHBG018163.
InParanoidiP0CB33.
KOiK09228.
PhylomeDBiP0CB33.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CB33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRPGPPGS REMGLLTFRD IAIEFSLAEW QCLDHAQQNL YRDVMLENYR
60 70 80 90 100
NLFSLGMTVS KPDLIACLEQ NKEPQNIKRN EMAAKHPVTC SHFNQDLQPE
110 120 130 140 150
QSIKDSLQKV IPRTYGKCGH ENLQLKKCCK RVDECEVHKG GYNDLNQCLS
160 170 180 190 200
NTQNKIFQTH KCVKVFSKFS NSNRHNARYT GKKHLKCKKY GKSFCMFSHL
210 220 230 240 250
NQHQIIHTKE KSYKCEECGK SFNHSSSGTT HKRILTGEKP YRCEECGKAF
260 270 280 290 300
RWPSNLTRHK RIHTGEKPYA CEECGQAFRR SSTLTNHKRI HTGERPYKCE
310 320 330 340 350
ECGKAFSVSS ALIYHKRIHT GEKPYTCEEC GKAFNCSSTL KTHKIIHTGE
360 370 380 390 400
KPYTCEECGR TFNCSSTVKA HKRIHTGEKP YKCEECDKAF KWHSSLAKHK
410
IIHTGEKPYK CK
Length:412
Mass (Da):47,565
Last modified:September 22, 2009 - v1
Checksum:i2E53E51DC216A02F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073270 Genomic DNA. No translation available.
AC104094 Genomic DNA. No translation available.
CCDSiCCDS78236.1.
RefSeqiNP_001152996.1. NM_001159524.1.
UniGeneiHs.723116.

Genome annotation databases

EnsembliENST00000429565; ENSP00000485547; ENSG00000223614.
GeneIDi730291.
KEGGihsa:730291.
UCSCiuc011kdn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073270 Genomic DNA. No translation available.
AC104094 Genomic DNA. No translation available.
CCDSiCCDS78236.1.
RefSeqiNP_001152996.1. NM_001159524.1.
UniGeneiHs.723116.

3D structure databases

ProteinModelPortaliP0CB33.
SMRiP0CB33. Positions 155-411.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP0CB33.
PhosphoSiteiP0CB33.

Polymorphism and mutation databases

BioMutaiZNF735.
DMDMi259710468.

Proteomic databases

EPDiP0CB33.
PeptideAtlasiP0CB33.
PRIDEiP0CB33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000429565; ENSP00000485547; ENSG00000223614.
GeneIDi730291.
KEGGihsa:730291.
UCSCiuc011kdn.3. human.

Organism-specific databases

CTDi730291.
GeneCardsiZNF735.
HGNCiHGNC:32466. ZNF735.
neXtProtiNX_P0CB33.
PharmGKBiPA162410268.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00790000122969.
HOVERGENiHBG018163.
InParanoidiP0CB33.
KOiK09228.
PhylomeDBiP0CB33.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii730291.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZN735_HUMAN
AccessioniPrimary (citable) accession number: P0CB33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: July 6, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.