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Protein

Putative zinc finger protein 735

Gene

ZNF735

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

May be involved in transcriptional regulation.HMP:

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri157 – 179C2H2-type 1; degenerateIEP:Add BLAST23
Zinc fingeri185 – 207C2H2-type 2; degenerateIEP:Add BLAST23
Zinc fingeri213 – 235C2H2-type 3; degenerateIEP:Add BLAST23
Zinc fingeri241 – 263C2H2-type 4IEP:Add BLAST23
Zinc fingeri269 – 291C2H2-type 5IEP:Add BLAST23
Zinc fingeri297 – 319C2H2-type 6IEP:Add BLAST23
Zinc fingeri325 – 347C2H2-type 7IEP:Add BLAST23
Zinc fingeri353 – 375C2H2-type 8IEP:Add BLAST23
Zinc fingeri381 – 403C2H2-type 9IEP:Add BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 735
Alternative name(s):
Zinc finger protein 735 pseudogene
Gene namesi
Name:ZNF735
Synonyms:ZNF735P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000223614.5.
HGNCiHGNC:32466. ZNF735.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi730291.
PharmGKBiPA162410268.

Polymorphism and mutation databases

BioMutaiZNF735.
DMDMi259710468.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003834751 – 412Putative zinc finger protein 735Add BLAST412

Proteomic databases

EPDiP0CB33.
MaxQBiP0CB33.
PeptideAtlasiP0CB33.
PRIDEiP0CB33.

PTM databases

iPTMnetiP0CB33.
PhosphoSitePlusiP0CB33.

Structurei

3D structure databases

ProteinModelPortaliP0CB33.
SMRiP0CB33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 87KRABIEP:Add BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri157 – 179C2H2-type 1; degenerateIEP:Add BLAST23
Zinc fingeri185 – 207C2H2-type 2; degenerateIEP:Add BLAST23
Zinc fingeri213 – 235C2H2-type 3; degenerateIEP:Add BLAST23
Zinc fingeri241 – 263C2H2-type 4IEP:Add BLAST23
Zinc fingeri269 – 291C2H2-type 5IEP:Add BLAST23
Zinc fingeri297 – 319C2H2-type 6IEP:Add BLAST23
Zinc fingeri325 – 347C2H2-type 7IEP:Add BLAST23
Zinc fingeri353 – 375C2H2-type 8IEP:Add BLAST23
Zinc fingeri381 – 403C2H2-type 9IEP:Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00890000139354.
HOVERGENiHBG018163.
InParanoidiP0CB33.
KOiK09228.
OMAiVTCSHFN.
PhylomeDBiP0CB33.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.

Sequencei

Sequence statusi: Complete.

P0CB33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRPGPPGS REMGLLTFRD IAIEFSLAEW QCLDHAQQNL YRDVMLENYR
60 70 80 90 100
NLFSLGMTVS KPDLIACLEQ NKEPQNIKRN EMAAKHPVTC SHFNQDLQPE
110 120 130 140 150
QSIKDSLQKV IPRTYGKCGH ENLQLKKCCK RVDECEVHKG GYNDLNQCLS
160 170 180 190 200
NTQNKIFQTH KCVKVFSKFS NSNRHNARYT GKKHLKCKKY GKSFCMFSHL
210 220 230 240 250
NQHQIIHTKE KSYKCEECGK SFNHSSSGTT HKRILTGEKP YRCEECGKAF
260 270 280 290 300
RWPSNLTRHK RIHTGEKPYA CEECGQAFRR SSTLTNHKRI HTGERPYKCE
310 320 330 340 350
ECGKAFSVSS ALIYHKRIHT GEKPYTCEEC GKAFNCSSTL KTHKIIHTGE
360 370 380 390 400
KPYTCEECGR TFNCSSTVKA HKRIHTGEKP YKCEECDKAF KWHSSLAKHK
410
IIHTGEKPYK CK
Length:412
Mass (Da):47,565
Last modified:September 22, 2009 - v1
Checksum:i2E53E51DC216A02F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073270 Genomic DNA. No translation available.
AC104094 Genomic DNA. No translation available.
CCDSiCCDS78236.1.
RefSeqiNP_001152996.1. NM_001159524.1.
UniGeneiHs.723116.

Genome annotation databases

EnsembliENST00000429565; ENSP00000485547; ENSG00000223614.
GeneIDi730291.
KEGGihsa:730291.
UCSCiuc011kdn.3. human.

Entry informationi

Entry nameiZN735_HUMAN
AccessioniPrimary (citable) accession number: P0CB33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 25, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.IKR:

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families