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Protein

Heat shock 70 kDa protein 1-like

Gene

HSPA1L

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). Positive regulator of PARK2 translocation to damaged mitochondria (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 174ATPBy similarity
Nucleotide bindingi204 – 2063ATPBy similarity
Nucleotide bindingi270 – 2778ATPBy similarity
Nucleotide bindingi341 – 3444ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 1-like
Short name:
Heat shock 70 kDa protein 1L
Gene namesi
Name:HSPA1L
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 641641Heat shock 70 kDa protein 1-likePRO_0000383115Add
BLAST

Proteomic databases

PaxDbiP0CB32.
PeptideAtlasiP0CB32.
PRIDEiP0CB32.

Expressioni

Gene expression databases

BgeeiENSBTAG00000025442.

Interactioni

Subunit structurei

Interacts with PARK2.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035635.

Structurei

3D structure databases

ProteinModelPortaliP0CB32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOGENOMiHOG000228135.
InParanoidiP0CB32.
KOiK03283.
OMAiKELENMC.
OrthoDBiEOG091G03SF.
TreeFamiTF105042.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CB32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKGTAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE
60 70 80 90 100
RLIGDAAKNQ VAMNPQNTVF DAKRLIGRKF NDPVVQSDMK LWPFQVINEG
110 120 130 140 150
GKPKVMVSYK GEKKAFYPEE ISSMVLTKMK ETAEAFLGYT VTNAVITVPA
160 170 180 190 200
YFNDSQRQAT KDAGVIAGLN VLRIINEPTA AAIAYGLDKA GQGERHVLIF
210 220 230 240 250
DLGGGTFDVS VLTIDDGIFE VKATAGDTHL GGEDFDNRLV SHFVEEFKRK
260 270 280 290 300
HKKDISQNKR AVRRLRTACE RAKRTLSSST QANLEIDSLY EGIDFYTSIT
310 320 330 340 350
RARFEELCAD LFRGTLEPVE KALRDAKMDK AKIHDIVLVG GSTRIPKVQR
360 370 380 390 400
LLQDYFNGRD LNKSINPDEA VAYGAAVQAA ILMGDKSEKV QDLLLLDVAP
410 420 430 440 450
LSLGLETAGG VMTVLIKRNS TIPTKQTQIF TTYSDNQPGV LIQVYEGERA
460 470 480 490 500
MTRDNNLLGR FDLTGIPPAP RGVPQIEVTF DIDANGILNV TAMDKSTGKA
510 520 530 540 550
NKITITNDKG RLSKEEIERM VLDAEKYKAE DEVQREKIAA KNALESYAFN
560 570 580 590 600
MKSAVSDEGL QGKISESDKK KILSKCNEVL LWLEANQLAE KDEFDHKRKE
610 620 630 640
LEQVCNPIIT KLYQGGCTGP SCGTGYTPGR AATGPTIEEV D
Length:641
Mass (Da):70,389
Last modified:September 1, 2009 - v1
Checksum:iB44CA29796F023ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03097356 Genomic DNA. No translation available.
RefSeqiNP_001161367.1. NM_001167895.1.
XP_005223735.1. XM_005223678.3.
UniGeneiBt.55003.

Genome annotation databases

EnsembliENSBTAT00000035766; ENSBTAP00000035635; ENSBTAG00000025442.
GeneIDi540190.
KEGGibta:540190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03097356 Genomic DNA. No translation available.
RefSeqiNP_001161367.1. NM_001167895.1.
XP_005223735.1. XM_005223678.3.
UniGeneiBt.55003.

3D structure databases

ProteinModelPortaliP0CB32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035635.

Proteomic databases

PaxDbiP0CB32.
PeptideAtlasiP0CB32.
PRIDEiP0CB32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000035766; ENSBTAP00000035635; ENSBTAG00000025442.
GeneIDi540190.
KEGGibta:540190.

Organism-specific databases

CTDi3305.

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOGENOMiHOG000228135.
InParanoidiP0CB32.
KOiK03283.
OMAiKELENMC.
OrthoDBiEOG091G03SF.
TreeFamiTF105042.

Miscellaneous databases

PROiP0CB32.

Gene expression databases

BgeeiENSBTAG00000025442.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHS71L_BOVIN
AccessioniPrimary (citable) accession number: P0CB32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 1, 2009
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.