Reviewed,
UniProtKB/Swiss-Prot P0CB22 (ATX2_ARATH)
Last modified
November 24, 2009.
Version 4.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone-lysine N-methyltransferase ATX2 EC=2.1.1.43 Alternative name(s): Trithorax-homolog protein 2 Short name=TRX-homolog protein 2 Protein SET DOMAIN GROUP 30 | ||||||||
| Gene names |
| ||||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 1083 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Histone methyltransferase By similarity. |
| Catalytic activity | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine. |
| Subcellular location | Nucleus By similarity. |
| Tissue specificity | Expressed in roots and flowers and, to a lower extent, in young seedlings. Ref.3 |
| Sequence similarities | Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. Contains 2 PHD-type zinc fingers. Contains 1 post-SET domain. Contains 1 PWWP domain. Contains 1 SET domain. |
| Sequence caution | The sequence AAF29390.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene has been split into 2 genes: At1g05830 and At1g05835. The sequence AK226560 differs from that shown. Reason: Frameshift at position 276. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Domain | Repeat Zinc-finger |
| Ligand | Metal-binding S-adenosyl-L-methionine Zinc |
| Molecular function | Chromatin regulator Methyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | DNA binding Inferred from electronic annotation. Source: InterPro histone-lysine N-methyltransferase activityInferred from electronic annotation. Source: EC protein bindingInferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1083 | 1083 | Histone-lysine N-methyltransferase ATX2 | PRO_0000233355 | |||||
Regions | |||||||||
| Domain | 315 – 379 | 65 | PWWP | ||||||
| Domain | 918 – 1041 | 124 | SET | ||||||
| Domain | 1043 – 1059 | 17 | Post-SET | ||||||
| Zinc finger | 626 – 677 | 52 | PHD-type 1 | ||||||
| Zinc finger | 740 – 767 | 28 | PHD-type 2; degenerate | ||||||
| Compositional bias | 41 – 48 | 8 | Poly-Ser | ||||||
| Compositional bias | 78 – 97 | 20 | Arg-rich | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. Davis R.W.Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [2] | "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. Shinozaki K.Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [3] | "Two Arabidopsis homologs of the animal trithorax genes: a new structural domain is a signature feature of the trithorax gene family." Alvarez-Venegas R., Avramova Z. Gene 271:215-221(2001) [PubMed: 11418242] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [4] | "The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes." Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B. Nucleic Acids Res. 29:4319-4333(2001) [PubMed: 11691919] [Abstract] Cited for: NOMENCLATURE. |
Web resources
| PlantsUBQ A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants |
Cross-references
Sequence databases | |
|---|---|
| AC009999 Genomic DNA. Translation: AAF29390.1. Sequence problems. AK226560 mRNA. No translation available. | |
| IPI | IPI00519225. |
| PIR | A86193. |
| RefSeq | NP_001077464.4. NP_172074.6. |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P0CB22. |
Genome annotation databases | |
| GeneID | 837093. |
Organism-specific databases | |
| TAIR | At1g05830. |
Enzyme and pathway databases | |
| BRENDA | 2.1.1.43. 302. |
Gene expression databases | |
| Genevestigator | P0CB22. |
| GermOnline | AT1G05830. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR003889. FYrich_C. IPR018516. FYrich_C_sg. IPR003888. FYrich_N. IPR018518. FYrich_N_sg. IPR003616. Post-SET_Zn_bd. IPR000313. PWWP. IPR001214. SET. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. [Graphical view] |
| Pfam | PF05965. FYRC. 1 hit. PF05964. FYRN. 1 hit. PF00628. PHD. 2 hits. PF00855. PWWP. 1 hit. PF00856. SET. 1 hit. [Graphical view] |
| SMART | SM00542. FYRC. 1 hit. SM00541. FYRN. 1 hit. SM00249. PHD. 2 hits. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view] |
| PROSITE | PS50868. POST_SET. 1 hit. PS50812. PWWP. 1 hit. PS50280. SET. 1 hit. PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ATX2_ARATH | ||||||||
| Accession | Primary (citable) accession number: P0CB22 Secondary accession number(s): Q8RXL4, Q9MA43 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


