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Protein

Putative disease resistance protein At4g19050

Gene

At4g19050

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Potential disease resistance protein.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 40ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Plant defense

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative disease resistance protein At4g19050
Gene namesi
Ordered Locus Names:At4g19050
ORF Names:F13C5.220, T18B16.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G19050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002127571 – 1201Putative disease resistance protein At4g19050Add BLAST1201

Proteomic databases

PaxDbiP0CB16.
PRIDEiP0CB16.

Interactioni

Protein-protein interaction databases

BioGridi12936. 1 interactor.
STRINGi3702.AT4G19050.1.

Structurei

3D structure databases

ProteinModelPortaliP0CB16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati469 – 491LRR 1Add BLAST23
Repeati492 – 514LRR 2Add BLAST23
Repeati517 – 539LRR 3Add BLAST23
Repeati540 – 562LRR 4Add BLAST23
Repeati680 – 701LRR 5Add BLAST22
Repeati703 – 725LRR 6Add BLAST23
Repeati726 – 748LRR 7Add BLAST23
Repeati750 – 771LRR 8Add BLAST22
Repeati773 – 795LRR 9Add BLAST23
Repeati796 – 818LRR 10Add BLAST23
Repeati820 – 841LRR 11Add BLAST22
Repeati843 – 865LRR 12Add BLAST23
Repeati866 – 888LRR 13Add BLAST23
Repeati890 – 911LRR 14Add BLAST22

Domaini

The LRR repeats probably act as specificity determinant of pathogen recognition.By similarity

Sequence similaritiesi

Belongs to the disease resistance NB-LRR family.Curated
Contains 14 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410J0Z0. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000090532.
InParanoidiP0CB16.
KOiK06685.
OMAiCWVERCK.
OrthoDBiEOG093601PY.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR032675. L_dom-like.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00931. NB-ARC. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CB16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKQDQTSRE EILKKIMDSL GQDGVPSKTV LVGEAGIGKT WLAKEVSQRV
60 70 80 90 100
TQEKYNVLWL HLNKKIEDEK SLYEILAAQL SIIYEFEEGE EPDELDYPLE
110 120 130 140 150
SLKEKIKEEM IKHKKDNLLL ILDDEGSMTT EEDVMQELNL QDFLKEYSAV
160 170 180 190 200
KILVTRRDER EEKESTTIKV GPLTEKESLD LLHDAEDLLT SFTSEDWPVL
210 220 230 240 250
LKRLCDNKEI KEPTLMSCIL SKSKGLPAAI VVLIKSLNSI KSMSAKQRKI
260 270 280 290 300
FKELILSSKS LDEAAASKNA IDRSRYNPVL QLSYELLKPD ETVKRPVIAC
310 320 330 340 350
FWHILDFYKY SGCAYYRDLI VHWMLEGYFD PVKSVDKAYQ EGHSILMDFM
360 370 380 390 400
NRGILKIQED NMVVPEFSMS NLLDLQDCGF FGRSSLGFDR VYGGDKRKGL
410 420 430 440 450
GKIILIDDMI QTIQSKKKNI TTIIASGNRL RREVHGKFFE KPEMQDLEVV
460 470 480 490 500
VLFEPTFHEL VLSLSKLKKL RVLVIRDCDL IDNIDKLSGL QGLHVLEVSG
510 520 530 540 550
ASSLVNIPDD FFKNMTQLQS LNLSGLAIKS SPSTIEKLSM LRCFILRHCS
560 570 580 590 600
ELQDLPNFIV ETRKLEVIDI HGARKLESYF DRVKDWKDYK GKNKNFAQLQ
610 620 630 640 650
LLEHLDFSET KIIRLPIFHL KDSTNDFSTM PILTRLLLRN CTRLKRLPQL
660 670 680 690 700
RPLTNLQILD ACGATDLVEM LEVCLEEKKE LRILDMSKTS LPELADTIAD
710 720 730 740 750
VVNLNKLLLR NCSLIEELPS IEKLTHLEVF DVSGCIKLKN INGSFGEMSY
760 770 780 790 800
LHEVNLSETN LSELPDKISE LSNLKELIIR KCSKLKTLPN LEKLTNLEIF
810 820 830 840 850
DVSGCTELET IEGSFENLSC LHKVNLSETN LGELPNKISE LSNLKELILR
860 870 880 890 900
NCSKLKALPN LEKLTHLVIF DVSGCTNLDK IEESFESMSY LCEVNLSGTN
910 920 930 940 950
LKTFPELPKQ SILCSSKRIV LADSSCIERD QWSQIKECLT SKSEGSSFSN
960 970 980 990 1000
VGEKTREKLL YHGNRYRVID PEVPLNIDIV DIKRSTDLKT EYIAKAEYVS
1010 1020 1030 1040 1050
IAENGSKSVS SLFDELQMAS VKGCWVERCK NMDVLFESDE QLEKEKSSSP
1060 1070 1080 1090 1100
SLQTLWISNL PLLTSLYSSK GGFIFKNLKK LSVDCCPSIK WLFPEIPDNL
1110 1120 1130 1140 1150
EILRVKFCDK LERLFEVKAG ELSKLRKLHL LDLPVLSVLG ANFPNLEKCT
1160 1170 1180 1190 1200
IEKCPKLKAR EDEPRIGARI TDEISEDQPH KNTIGPETQT PTQPTKATDT

V
Length:1,201
Mass (Da):136,827
Last modified:May 31, 2011 - v2
Checksum:i0108CC8A0F1121F9
GO

Sequence cautioni

The sequence CAA16762 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g19050 has been split into 2 genes: At4g19045 and At4g19050.Curated
The sequence CAB78907 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g19050 has been split into 2 genes: At4g19045 and At4g19050.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021711 Genomic DNA. Translation: CAA16762.1. Sequence problems.
AL161550 Genomic DNA. Translation: CAB78907.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE84134.1.
PIRiT04426.
RefSeqiNP_193640.4. NM_118023.5.
UniGeneiAt.74500.

Genome annotation databases

EnsemblPlantsiAT4G19050.1; AT4G19050.1; AT4G19050.
GeneIDi827643.
GrameneiAT4G19050.1; AT4G19050.1; AT4G19050.
KEGGiath:AT4G19050.

Cross-referencesi

Web resourcesi

NIB-LRRS

Functional and comparative genomics of disease resistance gene homologs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021711 Genomic DNA. Translation: CAA16762.1. Sequence problems.
AL161550 Genomic DNA. Translation: CAB78907.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE84134.1.
PIRiT04426.
RefSeqiNP_193640.4. NM_118023.5.
UniGeneiAt.74500.

3D structure databases

ProteinModelPortaliP0CB16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi12936. 1 interactor.
STRINGi3702.AT4G19050.1.

Proteomic databases

PaxDbiP0CB16.
PRIDEiP0CB16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G19050.1; AT4G19050.1; AT4G19050.
GeneIDi827643.
GrameneiAT4G19050.1; AT4G19050.1; AT4G19050.
KEGGiath:AT4G19050.

Organism-specific databases

TAIRiAT4G19050.

Phylogenomic databases

eggNOGiENOG410J0Z0. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000090532.
InParanoidiP0CB16.
KOiK06685.
OMAiCWVERCK.
OrthoDBiEOG093601PY.

Miscellaneous databases

PROiP0CB16.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR032675. L_dom-like.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00931. NB-ARC. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDRL25_ARATH
AccessioniPrimary (citable) accession number: P0CB16
Secondary accession number(s): O50052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 31, 2011
Last modified: November 2, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.