P0CAX3 (DCUP_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	CC_3763

Organism

Caulobacter crescentus (Caulobacter vibrioides)

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen III to yield coproporphyrinogen III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm Probable HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000187592
Regions
	Region	32 – 36	5	Substrate binding By similarity
Sites
	Binding site	51	1	Substrate By similarity
	Binding site	82	1	Substrate By similarity
	Binding site	157	1	Substrate By similarity
	Binding site	211	1	Substrate By similarity
	Binding site	326	1	Substrate By similarity
	Site	82	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0CAX3 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: E33D7A2C98765EE8	FASTA	351	37,944
	10 20 30 40 50 60 MTSSSPILKQ TPKFLSALEG QSHANPPVWF MRQAGRYLPE YRAVRATAPD FISFCFDPEK 70 80 90 100 110 120 AAEVTLQPMR RFPFDASIVF ADILLIPGAL GQKVWFEAGE GPKLGDMPSV ESMAEKAGEA 130 140 150 160 170 180 GKALSLVGET LTRVRSALDP DKALIGFAGA PWTVATYMIE KGSSDRSGAR TFAYQNPETL 190 200 210 220 230 240 DALIQVLVDA TIDYLAMQVD AGAQALKLFE SWAEGLSEPL FDRLVTQPHI RIIEGLRARG 250 260 270 280 290 300 VTVPIIGFPR GAGTLVEDYA ARTPVQGVAL DTSASAKLGQ TIQKTKTIQG ALDPLLLRAG 310 320 330 340 350 GDALLKRVDE MLEQWNQGPY IFNLGHGILP DTPIAHVEAV LERVTGQKVG Q

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK25725.1.
PIR	A87716.
RefSeq	NP_422557.1. NC_002696.2.
3D structure databases
ProteinModelPortal	P0CAX3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	942463.
GenomeReviews	Gene locus CC_3763 in contig AE005673_GR.
KEGG	ccr:CC_3763.
PATRIC	21304564. VBICauCre124313_3765.
TIGR	CC_3763.
Phylogenomic databases
OMA	PRIHFGV.
ProtClustDB	CLSK891699.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_CAUCR

Accession

Primary (citable) accession number: P0CAX3
Secondary accession number(s): Q59269

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	January 25, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program