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P0CAW2

- MTC1_CAUCR

UniProt

P0CAW2 - MTC1_CAUCR

Protein

Modification methylase CcrMI

Gene

ccrMIM

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. Ccrm-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCAULO:CC0378-MONOMER.

    Protein family/group databases

    REBASEi2539. M.CcrMI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase CcrMI (EC:2.1.1.72)
    Short name:
    M.CcrMI
    Alternative name(s):
    Adenine-specific methyltransferase CcrMI
    Gene namesi
    Name:ccrMIM
    Synonyms:ccrM
    Ordered Locus Names:CC_0378
    OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
    Taxonomic identifieri190650 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Modification methylase CcrMIPRO_0000087987Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0CAW2.
    SMRiP0CAW2. Positions 12-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0863.
    HOGENOMiHOG000125329.
    KOiK13581.
    OMAiFWHFEDG.
    OrthoDBiEOG6FV84T.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01555. N6_N4_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00508. S21N4MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CAW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFGPETIIH GDCIEQMNAL PEKSVDLIFA DPPYNLQLGG DLLRPDNSKV    50
    DAVDDHWDQF ESFAAYDKFT REWLKAARRV LKDDGAIWVI GSYHNIFRVG 100
    VAVQDLGFWI LNDIVWRKSN PMPNFKGTRF ANAHETLIWA SKSQNAKRYT 150
    FNYDALKMAN DEVQMRSDWT IPLCTGEERI KGADGQKAHP TQKPEALLYR 200
    VILSTTKPGD VILDPFFGVG TTGAAAKRLG RKFIGIEREA EYLEHAKARI 250
    AKVVPIAPED LDVMGSKRAE PRVPFGTIVE AGLLSPGDTL YCSKGTHVAK 300
    VRPDGSITVG DLSGSIHKIG ALVQSAPACN GWTYWHFKTD AGLAPIDVLR 350
    AQVRAGMN 358
    Length:358
    Mass (Da):39,665
    Last modified:June 16, 2009 - v1
    Checksum:i05F43266F7D4C614
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK22365.1.
    PIRiA87296.
    RefSeqiNP_419197.1. NC_002696.2.
    WP_010918266.1. NC_002696.2.

    Genome annotation databases

    EnsemblBacteriaiAAK22365; AAK22365; CC_0378.
    GeneIDi942157.
    KEGGiccr:CC_0378.
    PATRICi21297684. VBICauCre124313_0380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK22365.1 .
    PIRi A87296.
    RefSeqi NP_419197.1. NC_002696.2.
    WP_010918266.1. NC_002696.2.

    3D structure databases

    ProteinModelPortali P0CAW2.
    SMRi P0CAW2. Positions 12-246.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 2539. M.CcrMI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK22365 ; AAK22365 ; CC_0378 .
    GeneIDi 942157.
    KEGGi ccr:CC_0378.
    PATRICi 21297684. VBICauCre124313_0380.

    Phylogenomic databases

    eggNOGi COG0863.
    HOGENOMi HOG000125329.
    KOi K13581.
    OMAi FWHFEDG.
    OrthoDBi EOG6FV84T.

    Enzyme and pathway databases

    BioCyci CAULO:CC0378-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01555. N6_N4_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00508. S21N4MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19089 / CB15.

    Entry informationi

    Entry nameiMTC1_CAUCR
    AccessioniPrimary (citable) accession number: P0CAW2
    Secondary accession number(s): Q45971
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3