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P0CAW2

- MTC1_CAUCR

UniProt

P0CAW2 - MTC1_CAUCR

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Protein
Modification methylase CcrMI
Gene
ccrMIM, ccrM, CC_0378
Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. Ccrm-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology By similarity.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCAULO:CC0378-MONOMER.

Protein family/group databases

REBASEi2539. M.CcrMI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase CcrMI (EC:2.1.1.72)
Short name:
M.CcrMI
Alternative name(s):
Adenine-specific methyltransferase CcrMI
Gene namesi
Name:ccrMIM
Synonyms:ccrM
Ordered Locus Names:CC_0378
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Modification methylase CcrMI
PRO_0000087987Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CAW2.
SMRiP0CAW2. Positions 12-246.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0863.
HOGENOMiHOG000125329.
KOiK13581.
OMAiFWHFEDG.
OrthoDBiEOG6FV84T.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CAW2-1 [UniParc]FASTAAdd to Basket

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MKFGPETIIH GDCIEQMNAL PEKSVDLIFA DPPYNLQLGG DLLRPDNSKV    50
DAVDDHWDQF ESFAAYDKFT REWLKAARRV LKDDGAIWVI GSYHNIFRVG 100
VAVQDLGFWI LNDIVWRKSN PMPNFKGTRF ANAHETLIWA SKSQNAKRYT 150
FNYDALKMAN DEVQMRSDWT IPLCTGEERI KGADGQKAHP TQKPEALLYR 200
VILSTTKPGD VILDPFFGVG TTGAAAKRLG RKFIGIEREA EYLEHAKARI 250
AKVVPIAPED LDVMGSKRAE PRVPFGTIVE AGLLSPGDTL YCSKGTHVAK 300
VRPDGSITVG DLSGSIHKIG ALVQSAPACN GWTYWHFKTD AGLAPIDVLR 350
AQVRAGMN 358
Length:358
Mass (Da):39,665
Last modified:June 16, 2009 - v1
Checksum:i05F43266F7D4C614
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005673 Genomic DNA. Translation: AAK22365.1.
PIRiA87296.
RefSeqiNP_419197.1. NC_002696.2.
WP_010918266.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22365; AAK22365; CC_0378.
GeneIDi942157.
KEGGiccr:CC_0378.
PATRICi21297684. VBICauCre124313_0380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005673 Genomic DNA. Translation: AAK22365.1 .
PIRi A87296.
RefSeqi NP_419197.1. NC_002696.2.
WP_010918266.1. NC_002696.2.

3D structure databases

ProteinModelPortali P0CAW2.
SMRi P0CAW2. Positions 12-246.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 2539. M.CcrMI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK22365 ; AAK22365 ; CC_0378 .
GeneIDi 942157.
KEGGi ccr:CC_0378.
PATRICi 21297684. VBICauCre124313_0380.

Phylogenomic databases

eggNOGi COG0863.
HOGENOMi HOG000125329.
KOi K13581.
OMAi FWHFEDG.
OrthoDBi EOG6FV84T.

Enzyme and pathway databases

BioCyci CAULO:CC0378-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF01555. N6_N4_Mtase. 1 hit.
[Graphical view ]
PRINTSi PR00508. S21N4MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiMTC1_CAUCR
AccessioniPrimary (citable) accession number: P0CAW2
Secondary accession number(s): Q45971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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