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Protein

Modification methylase CcrMI

Gene

ccrMIM

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. Ccrm-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCAULO:CC0378-MONOMER.

Protein family/group databases

REBASEi2539. M.CcrMI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase CcrMI (EC:2.1.1.72)
Short name:
M.CcrMI
Alternative name(s):
Adenine-specific methyltransferase CcrMI
Gene namesi
Name:ccrMIM
Synonyms:ccrM
Ordered Locus Names:CC_0378
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Modification methylase CcrMIPRO_0000087987Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_0378.

Structurei

3D structure databases

ProteinModelPortaliP0CAW2.
SMRiP0CAW2. Positions 12-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0863.
HOGENOMiHOG000125329.
KOiK13581.
OMAiFWHFEDG.
OrthoDBiEOG6FV84T.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CAW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFGPETIIH GDCIEQMNAL PEKSVDLIFA DPPYNLQLGG DLLRPDNSKV
60 70 80 90 100
DAVDDHWDQF ESFAAYDKFT REWLKAARRV LKDDGAIWVI GSYHNIFRVG
110 120 130 140 150
VAVQDLGFWI LNDIVWRKSN PMPNFKGTRF ANAHETLIWA SKSQNAKRYT
160 170 180 190 200
FNYDALKMAN DEVQMRSDWT IPLCTGEERI KGADGQKAHP TQKPEALLYR
210 220 230 240 250
VILSTTKPGD VILDPFFGVG TTGAAAKRLG RKFIGIEREA EYLEHAKARI
260 270 280 290 300
AKVVPIAPED LDVMGSKRAE PRVPFGTIVE AGLLSPGDTL YCSKGTHVAK
310 320 330 340 350
VRPDGSITVG DLSGSIHKIG ALVQSAPACN GWTYWHFKTD AGLAPIDVLR

AQVRAGMN
Length:358
Mass (Da):39,665
Last modified:June 16, 2009 - v1
Checksum:i05F43266F7D4C614
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22365.1.
PIRiA87296.
RefSeqiNP_419197.1. NC_002696.2.
WP_010918266.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22365; AAK22365; CC_0378.
GeneIDi942157.
KEGGiccr:CC_0378.
PATRICi21297684. VBICauCre124313_0380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22365.1.
PIRiA87296.
RefSeqiNP_419197.1. NC_002696.2.
WP_010918266.1. NC_002696.2.

3D structure databases

ProteinModelPortaliP0CAW2.
SMRiP0CAW2. Positions 12-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_0378.

Protein family/group databases

REBASEi2539. M.CcrMI.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK22365; AAK22365; CC_0378.
GeneIDi942157.
KEGGiccr:CC_0378.
PATRICi21297684. VBICauCre124313_0380.

Phylogenomic databases

eggNOGiCOG0863.
HOGENOMiHOG000125329.
KOiK13581.
OMAiFWHFEDG.
OrthoDBiEOG6FV84T.

Enzyme and pathway databases

BioCyciCAULO:CC0378-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiMTC1_CAUCR
AccessioniPrimary (citable) accession number: P0CAW2
Secondary accession number(s): Q45971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: June 24, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.