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Protein

Lon protease

Gene

lon

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). CcrM is an important target of the Lon protease pathway in C.crescentus (By similarity).UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei674UniRule annotation1
Active sitei717UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi352 – 359ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAULO:CC1960-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
ATP-dependent protease LaUniRule annotation
Gene namesi
Name:lonUniRule annotation
Ordered Locus Names:CC_1960
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761291 – 799Lon proteaseAdd BLAST799

Expressioni

Inductioni

By heat shock.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_1960

Structurei

3D structure databases

ProteinModelPortaliP0CAW0
SMRiP0CAW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 198Lon N-terminalPROSITE-ProRule annotationAdd BLAST192
Domaini587 – 768Lon proteolyticPROSITE-ProRule annotationAdd BLAST182

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6P Bacteria
COG0466 LUCA
HOGENOMiHOG000261410
KOiK01338
OMAiPILCLYG

Family and domain databases

Gene3Di3.30.230.10, 1 hit
HAMAPiMF_01973 lon_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027543 Lon_bac
IPR004815 Lon_bac/euk-typ
IPR008269 Lon_proteolytic
IPR027065 Lon_Prtase
IPR003111 Lon_substr-bd
IPR027417 P-loop_NTPase
IPR008268 Peptidase_S16_AS
IPR015947 PUA-like_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10046 PTHR10046, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF05362 Lon_C, 1 hit
PF02190 LON_substr_bdg, 1 hit
PIRSFiPIRSF001174 Lon_proteas, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00464 LON, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54211 SSF54211, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00763 lon, 1 hit
PROSITEiView protein in PROSITE
PS51787 LON_N, 1 hit
PS51786 LON_PROTEOLYTIC, 1 hit
PS01046 LON_SER, 1 hit

Sequencei

Sequence statusi: Complete.

P0CAW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELRTLPVL PLRDIVVFPH MVVPLFVGRD KSVRALEEVM RGDKQILLVT
60 70 80 90 100
QKNSADDDPA PGDIFEVGVL ATVLQLLKLP DGTVKVLVEG KARAAVVSFT
110 120 130 140 150
DQESYYEAQI GEVSEDDGAG PEAEALSRAV VEQFENYVKL NKKVPPEALA
160 170 180 190 200
SIPQIAEPGK LADSIAAHLS VKIGDKQNLL EIFDVVKRLE KVFALMEGEI
210 220 230 240 250
SVLQVEKKIR SRVKRQMEKT QREYYLNEQM KAIQRELGDP DDARDELIDL
260 270 280 290 300
EKRIKKTKLS KEARTKAESE LKKLRNMSPM SAESTVVRNY LDWLLSIPWG
310 320 330 340 350
KAKTKKIDLV ESEGILDADH YGLEKVKERI LEYLAVQART NSLKGPILCL
360 370 380 390 400
VGPPGVGKTS LGKSIAKATG REFVRMSLGG VRDEAEIRGH RRTYIGSMPG
410 420 430 440 450
KVVQSMKKAK TTNAFVLLDE IDKMGSDYRG DPASALLEVL DPSQNSTFGD
460 470 480 490 500
HYLEVDYDLS QVMFVTTANS LNMPQPLLDR MEIIRIPGYT EDEKLEIAKR
510 520 530 540 550
HILPKLAKDH GLKPAEFIVP DKAIRDLIRY YTREAGVRSL ERELGALARK
560 570 580 590 600
TVRDLAREKV ASITIDDERL AKYAGVKKYR YGETDEVDQV GIVTGLAWTE
610 620 630 640 650
FGGDILTIEA VKMPGKGRMQ ITGNLKDVMK ESIAAANSYV RSRALQFGIK
660 670 680 690 700
PPVFEKTDVH IHVPDGATPK DGPSAGIAMA LAMVSVLTGI PIRKDIAMTG
710 720 730 740 750
EITLRGRVTA IGGLKEKLLA ALRSGVKTVL IPQENEKDLA DVPQTVKDGL
760 770 780 790
EIIPVSTVDE VLKHALTGPL TPVEWNEAEE PITTSAKKDD GDSDAMLTH
Length:799
Mass (Da):88,244
Last modified:June 16, 2009 - v1
Checksum:i72911212A74C48D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK23935.1
PIRiC87492
RefSeqiNP_420767.1, NC_002696.2
WP_010919826.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK23935; AAK23935; CC_1960
GeneIDi942700
KEGGiccr:CC_1960
PATRICifig|190650.5.peg.1976

Similar proteinsi

Entry informationi

Entry nameiLON_CAUVC
AccessioniPrimary (citable) accession number: P0CAW0
Secondary accession number(s): P52977
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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