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Protein

Lon protease

Gene

lon

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). CcrM is an important target of the Lon protease pathway in C.crescentus (By similarity).UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei674 – 6741UniRule annotation
Active sitei717 – 7171UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi352 – 3598ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAULO:CC1960-MONOMER.

Protein family/group databases

MEROPSiS16.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
ATP-dependent protease LaUniRule annotation
Gene namesi
Name:lonUniRule annotation
Ordered Locus Names:CC_1960
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 799799Lon proteasePRO_0000076129Add
BLAST

Expressioni

Inductioni

By heat shock.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_1960.

Structurei

3D structure databases

ProteinModelPortaliP0CAW0.
SMRiP0CAW0. Positions 7-241, 246-766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 198192Lon N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini587 – 768182Lon proteolyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation
Contains 1 Lon N-terminal domain.PROSITE-ProRule annotation
Contains 1 Lon proteolytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105C6P. Bacteria.
COG0466. LUCA.
HOGENOMiHOG000261410.
KOiK01338.
OMAiVVFPYMM.
OrthoDBiEOG6XHC23.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CAW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELRTLPVL PLRDIVVFPH MVVPLFVGRD KSVRALEEVM RGDKQILLVT
60 70 80 90 100
QKNSADDDPA PGDIFEVGVL ATVLQLLKLP DGTVKVLVEG KARAAVVSFT
110 120 130 140 150
DQESYYEAQI GEVSEDDGAG PEAEALSRAV VEQFENYVKL NKKVPPEALA
160 170 180 190 200
SIPQIAEPGK LADSIAAHLS VKIGDKQNLL EIFDVVKRLE KVFALMEGEI
210 220 230 240 250
SVLQVEKKIR SRVKRQMEKT QREYYLNEQM KAIQRELGDP DDARDELIDL
260 270 280 290 300
EKRIKKTKLS KEARTKAESE LKKLRNMSPM SAESTVVRNY LDWLLSIPWG
310 320 330 340 350
KAKTKKIDLV ESEGILDADH YGLEKVKERI LEYLAVQART NSLKGPILCL
360 370 380 390 400
VGPPGVGKTS LGKSIAKATG REFVRMSLGG VRDEAEIRGH RRTYIGSMPG
410 420 430 440 450
KVVQSMKKAK TTNAFVLLDE IDKMGSDYRG DPASALLEVL DPSQNSTFGD
460 470 480 490 500
HYLEVDYDLS QVMFVTTANS LNMPQPLLDR MEIIRIPGYT EDEKLEIAKR
510 520 530 540 550
HILPKLAKDH GLKPAEFIVP DKAIRDLIRY YTREAGVRSL ERELGALARK
560 570 580 590 600
TVRDLAREKV ASITIDDERL AKYAGVKKYR YGETDEVDQV GIVTGLAWTE
610 620 630 640 650
FGGDILTIEA VKMPGKGRMQ ITGNLKDVMK ESIAAANSYV RSRALQFGIK
660 670 680 690 700
PPVFEKTDVH IHVPDGATPK DGPSAGIAMA LAMVSVLTGI PIRKDIAMTG
710 720 730 740 750
EITLRGRVTA IGGLKEKLLA ALRSGVKTVL IPQENEKDLA DVPQTVKDGL
760 770 780 790
EIIPVSTVDE VLKHALTGPL TPVEWNEAEE PITTSAKKDD GDSDAMLTH
Length:799
Mass (Da):88,244
Last modified:June 16, 2009 - v1
Checksum:i72911212A74C48D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK23935.1.
PIRiC87492.
RefSeqiNP_420767.1. NC_002696.2.
WP_010919826.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK23935; AAK23935; CC_1960.
GeneIDi942700.
KEGGiccr:CC_1960.
PATRICi21300928. VBICauCre124313_1976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK23935.1.
PIRiC87492.
RefSeqiNP_420767.1. NC_002696.2.
WP_010919826.1. NC_002696.2.

3D structure databases

ProteinModelPortaliP0CAW0.
SMRiP0CAW0. Positions 7-241, 246-766.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_1960.

Protein family/group databases

MEROPSiS16.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK23935; AAK23935; CC_1960.
GeneIDi942700.
KEGGiccr:CC_1960.
PATRICi21300928. VBICauCre124313_1976.

Phylogenomic databases

eggNOGiENOG4105C6P. Bacteria.
COG0466. LUCA.
HOGENOMiHOG000261410.
KOiK01338.
OMAiVVFPYMM.
OrthoDBiEOG6XHC23.

Enzyme and pathway databases

BioCyciCAULO:CC1960-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiLON_CAUCR
AccessioniPrimary (citable) accession number: P0CAW0
Secondary accession number(s): P52977
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: February 17, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.