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P0CAT2 (S238B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 25 member 38-B
Gene names
Name:slc25a38b
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane By similarity. HAMAP-Rule MF_03064

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_03064.

Disruption phenotype

Fishes lacking both slc25a38a and slc25a38b display anemia. Ref.2

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Solute carrier family 25 member 38-B HAMAP-Rule MF_03064
PRO_0000378921

Regions

Transmembrane13 – 3826Helical; Name=1; Potential
Transmembrane72 – 9827Helical; Name=2; Potential
Transmembrane110 – 13526Helical; Name=3; Potential
Transmembrane163 – 18624Helical; Name=4; Potential
Transmembrane202 – 22827Helical; Name=5; Potential
Transmembrane257 – 27519Helical; Name=6; Potential
Repeat7 – 9791Solcar 1 HAMAP-Rule MF_03064
Repeat104 – 18885Solcar 2 HAMAP-Rule MF_03064
Repeat198 – 28285Solcar 3 HAMAP-Rule MF_03064

Sequences

Sequence LengthMass (Da)Tools
P0CAT2 [UniParc].

Last modified February 19, 2014. Version 2.
Checksum: DAD41466C96E5540

FASTA28730,986
        10         20         30         40         50         60 
MEVALAHPAL KAFMCGSLSG TCSTLLFQPL DLVKTRLQTL QNNMHPGAPK VGMITVLFNV 

        70         80         90        100        110        120 
IRTEKLLGLW KGVSPSFMRC IPGVGIYFST FYSLKQHYFQ EGSPSAGEAV LLGAGARCVA 

       130        140        150        160        170        180 
GVAMLPFTVI KTRFESGRYN YISVAGALKS VCQNEGPKAL YSGLTATLLR DAPFSGIYVM 

       190        200        210        220        230        240 
FYSQAKKALP QEISSSSIAP LVNFGCGVVA GILASLATQP ADVIKTHMQV SPALYPKTSD 

       250        260        270        280 
AMRHVYVKHG LSGFFRGAVP RSLRRTLMAA MAWTVYEQLM ARMGLKS 

« Hide

References

« Hide 'large scale' references
[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[2]"Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia."
Guernsey D.L., Jiang H., Campagna D.R., Evans S.C., Ferguson M., Kellogg M.D., Lachance M., Matsuoka M., Nightingale M., Rideout A., Saint-Amant L., Schmidt P.J., Orr A., Bottomley S.S., Fleming M.D., Ludman M., Dyack S., Fernandez C.V., Samuels M.E.
Nat. Genet. 41:651-653(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR925711 Genomic DNA. No translation available.
RefSeqNP_001189387.1. NM_001202458.1.
UniGeneDr.94238.

3D structure databases

ProteinModelPortalP0CAT2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000151545; ENSDARP00000126117; ENSDARG00000074533.
GeneID571961.
KEGGdre:571961.

Organism-specific databases

CTD571961.
ZFINZDB-GENE-110214-1. slc25a38b.

Phylogenomic databases

GeneTreeENSGT00550000075117.
HOGENOMHOG000006978.
OrthoDBEOG7BGHMD.
PhylomeDBP0CAT2.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
HAMAPMF_03064. SLC25A38.
InterProIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00926. MITOCARRIER.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameS238B_DANRE
AccessionPrimary (citable) accession number: P0CAT2
Secondary accession number(s): I3IT61
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: February 19, 2014
Last modified: April 16, 2014
This is version 30 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families