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Protein

Mitochondrial glycine transporter B

Gene

slc25a38b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • erythrocyte differentiation Source: UniProtKB
  • glycine import into mitochondrion Source: InterPro
  • hemoglobin biosynthetic process Source: ZFIN
  • hemoglobin metabolic process Source: ZFIN
  • mitochondrial transport Source: GO_Central

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporter BUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38-BUniRule annotation
Gene namesi
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-110214-1 slc25a38b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 38Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei72 – 98Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei110 – 135Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei163 – 186Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei202 – 228Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei257 – 275Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Fishes lacking both slc25a38a and slc25a38b display anemia.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789211 – 287Mitochondrial glycine transporter BAdd BLAST287

Proteomic databases

PaxDbiP0CAT2

Expressioni

Tissue specificityi

At 24 hours post-fertilization, expressed predominantly in posterior blood island, posterior cardinal vein and circulating blood. At 34 hours post-fertilization, becomes restricted to posterior blood island and circulating blood.1 Publication

Gene expression databases

BgeeiENSDARG00000074533
ExpressionAtlasiP0CAT2 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000106419

Structurei

3D structure databases

ProteinModelPortaliP0CAT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 97Solcar 1UniRule annotationAdd BLAST91
Repeati104 – 188Solcar 2UniRule annotationAdd BLAST85
Repeati198 – 282Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766 Eukaryota
ENOG410XRMK LUCA
GeneTreeiENSGT00550000075117
HOGENOMiHOG000006978
InParanoidiP0CAT2
KOiK15118

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P0CAT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVALAHPAL KAFMCGSLSG TCSTLLFQPL DLVKTRLQTL QNNMHPGAPK
60 70 80 90 100
VGMITVLFNV IRTEKLLGLW KGVSPSFMRC IPGVGIYFST FYSLKQHYFQ
110 120 130 140 150
EGSPSAGEAV LLGAGARCVA GVAMLPFTVI KTRFESGRYN YISVAGALKS
160 170 180 190 200
VCQNEGPKAL YSGLTATLLR DAPFSGIYVM FYSQAKKALP QEISSSSIAP
210 220 230 240 250
LVNFGCGVVA GILASLATQP ADVIKTHMQV SPALYPKTSD AMRHVYVKHG
260 270 280
LSGFFRGAVP RSLRRTLMAA MAWTVYEQLM ARMGLKS
Length:287
Mass (Da):30,986
Last modified:February 19, 2014 - v2
Checksum:iDAD41466C96E5540
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925711 Genomic DNA No translation available.
RefSeqiNP_001189387.1, NM_001202458.1
UniGeneiDr.94238

Genome annotation databases

EnsembliENSDART00000151545; ENSDARP00000126117; ENSDARG00000074533
GeneIDi571961
KEGGidre:571961

Similar proteinsi

Entry informationi

Entry nameiS238B_DANRE
AccessioniPrimary (citable) accession number: P0CAT2
Secondary accession number(s): I3IT61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: February 19, 2014
Last modified: May 23, 2018
This is version 51 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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