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P0CAT2

- S238B_DANRE

UniProt

P0CAT2 - S238B_DANRE

Protein

Solute carrier family 25 member 38-B

Gene

slc25a38b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 2 (19 Feb 2014)
      Previous versions | rss
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    Functioni

    Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

    GO - Biological processi

    1. erythrocyte differentiation Source: UniProtKB
    2. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 25 member 38-BUniRule annotation
    Gene namesi
    Name:slc25a38b
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 6, UP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-110214-1. slc25a38b.

    Subcellular locationi

    Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Disruption phenotypei

    Fishes lacking both slc25a38a and slc25a38b display anemia.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Solute carrier family 25 member 38-BPRO_0000378921Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0CAT2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3826Helical; Name=1UniRule annotationAdd
    BLAST
    Transmembranei72 – 9827Helical; Name=2UniRule annotationAdd
    BLAST
    Transmembranei110 – 13526Helical; Name=3UniRule annotationAdd
    BLAST
    Transmembranei163 – 18624Helical; Name=4UniRule annotationAdd
    BLAST
    Transmembranei202 – 22827Helical; Name=5UniRule annotationAdd
    BLAST
    Transmembranei257 – 27519Helical; Name=6UniRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati7 – 9791Solcar 1Add
    BLAST
    Repeati104 – 18885Solcar 2Add
    BLAST
    Repeati198 – 28285Solcar 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation
    Contains 3 Solcar repeats.UniRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00550000075117.
    HOGENOMiHOG000006978.
    KOiK15118.
    OrthoDBiEOG7BGHMD.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    HAMAPiMF_03064. SLC25A38.
    InterProiIPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CAT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVALAHPAL KAFMCGSLSG TCSTLLFQPL DLVKTRLQTL QNNMHPGAPK    50
    VGMITVLFNV IRTEKLLGLW KGVSPSFMRC IPGVGIYFST FYSLKQHYFQ 100
    EGSPSAGEAV LLGAGARCVA GVAMLPFTVI KTRFESGRYN YISVAGALKS 150
    VCQNEGPKAL YSGLTATLLR DAPFSGIYVM FYSQAKKALP QEISSSSIAP 200
    LVNFGCGVVA GILASLATQP ADVIKTHMQV SPALYPKTSD AMRHVYVKHG 250
    LSGFFRGAVP RSLRRTLMAA MAWTVYEQLM ARMGLKS 287
    Length:287
    Mass (Da):30,986
    Last modified:February 19, 2014 - v2
    Checksum:iDAD41466C96E5540
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR925711 Genomic DNA. No translation available.
    RefSeqiNP_001189387.1. NM_001202458.1.
    UniGeneiDr.94238.

    Genome annotation databases

    EnsembliENSDART00000151545; ENSDARP00000126117; ENSDARG00000074533.
    GeneIDi571961.
    KEGGidre:571961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR925711 Genomic DNA. No translation available.
    RefSeqi NP_001189387.1. NM_001202458.1.
    UniGenei Dr.94238.

    3D structure databases

    ProteinModelPortali P0CAT2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000151545 ; ENSDARP00000126117 ; ENSDARG00000074533 .
    GeneIDi 571961.
    KEGGi dre:571961.

    Organism-specific databases

    CTDi 571961.
    ZFINi ZDB-GENE-110214-1. slc25a38b.

    Phylogenomic databases

    GeneTreei ENSGT00550000075117.
    HOGENOMi HOG000006978.
    KOi K15118.
    OrthoDBi EOG7BGHMD.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    HAMAPi MF_03064. SLC25A38.
    InterProi IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiS238B_DANRE
    AccessioniPrimary (citable) accession number: P0CAT2
    Secondary accession number(s): I3IT61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: February 19, 2014
    Last modified: October 1, 2014
    This is version 33 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3