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Protein

Alpha-conotoxin-like Qc1.4a

Gene
N/A
Organism
Conus quercinus (Oak cone)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-like Qc1.4a
OrganismiConus quercinus (Oak cone)
Taxonomic identifieri101313 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConusLividoconus

Organism-specific databases

ConoServeri558 Qc1.4a precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000370673‹1 – 19By similarityAdd BLAST›19
PeptideiPRO_000037067420 – 36Alpha-conotoxin-like Qc1.4aAdd BLAST17
PropeptideiPRO_000037067537 – 40By similarity4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 28By similarity
Disulfide bondi23 ↔ 36By similarity
Modified residuei36Cysteine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Proteomic databases

PRIDEiP0CAQ8

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliP0CAQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CAQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40
SDGRNTAAND KASDLMALRD GCCSNPSCSV NNPDICGGGR
Length:40
Mass (Da):4,043
Last modified:June 16, 2009 - v1
Checksum:i699222C37061EE62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ311068 Genomic DNA Translation: ABD33860.1

Similar proteinsi

Entry informationi

Entry nameiCA14A_CONQU
AccessioniPrimary (citable) accession number: P0CAQ8
Secondary accession number(s): A1X8C8, A1X8C9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: May 23, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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