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Protein

Alpha-conotoxin-like Lp1.6a

Gene
N/A
Organism
Conus leopardus (Leopard cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-like Lp1.6a1 Publication
OrganismiConus leopardus (Leopard cone)
Taxonomic identifieri101306 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri547. Lp1.6a precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000037065222 – 44By similarityAdd BLAST23
PeptideiPRO_000037685045 – 60Alpha-conotoxin-like Lp1.6a1 PublicationAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi47 ↔ 53By similarity
Disulfide bondi48 ↔ 60By similarity
Modified residuei60Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0CAQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/6 pattern.Curated

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CAQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMMFIIF LFVVLATTVV SFTSGRASDG RNAPANNKVS DLIRQFCCGH
60
YDCDFIPNVC G
Length:61
Mass (Da):6,739
Last modified:June 16, 2009 - v1
Checksum:iF6265D8D68E7722A
GO

Sequence cautioni

The sequence ABD48796 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ311057 Genomic DNA. Translation: ABD33849.1.
DQ359145 Genomic DNA. Translation: ABD48796.1. Different initiation.

Similar proteinsi

Entry informationi

Entry nameiCA16A_CONLE
AccessioniPrimary (citable) accession number: P0CAQ6
Secondary accession number(s): A1X8B7, A6M937, A6M939
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: November 22, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families