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Protein

Alpha-conotoxin-like Ac1.1b

Gene
N/A
Organism
Conus achatinus (Little frog cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-like Ac1.1b
OrganismiConus achatinus (Little frog cone)
Taxonomic identifieri369967 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri545. Ac1.1b precursor.
571. Ac1.1b precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000037684822 – 47By similarityAdd BLAST26
PeptideiPRO_000037684948 – 62Alpha-conotoxin-like Ac1.1bAdd BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 56By similarity
Disulfide bondi52 ↔ 62By similarity
Modified residuei62Cysteine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliP0CAQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha3/5 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
IPR018072. Conotoxin_a-typ_CS.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.
PROSITEiView protein in PROSITE
PS60014. ALPHA_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CAQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMMFTLF LLVVLTTTVV SFPSDSASDG RDDEAKDERS DMYKSKRNGR
60
CCHPACGKHF SCGR
Length:64
Mass (Da):7,181
Last modified:June 16, 2009 - v1
Checksum:iC4F719D02BF22F6E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9L → V in ABD33847 (PubMed:17400270).Curated1
Sequence conflicti22F → Y in ABD33847 (PubMed:17400270).Curated1
Sequence conflicti44K → E in ABD33847 (PubMed:17400270).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ359139 mRNA. Translation: ABD48790.1.
DQ311055 Genomic DNA. Translation: ABD33847.1.

Similar proteinsi

Entry informationi

Entry nameiCA11B_CONAH
AccessioniPrimary (citable) accession number: P0CAQ5
Secondary accession number(s): A1X8B5
, A3DT43, A6M932, A6M933
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: November 22, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families