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Protein

Kappa-conotoxin-like Ac4.3a

Gene
N/A
Organism
Conus achatinus (Little frog cone)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Kappa-conotoxins bind and inhibit voltage-gated potassium channels.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin-like Ac4.3a
OrganismiConus achatinus (Little frog cone)
Taxonomic identifieri369967 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri564 Ac4.3a precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000370644‹1 – 11Add BLAST›11
PeptideiPRO_000037064512 – 47Kappa-conotoxin-like Ac4.3aAdd BLAST36
PropeptideiPRO_000037064648 – 52By similarity5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12Pyrrolidone carboxylic acidBy similarity1
Modified residuei144-carboxyglutamateBy similarity1
Modified residuei284-hydroxyprolineBy similarity1
Modified residuei334-hydroxyprolineBy similarity1
Modified residuei474-hydroxyprolineBy similarity1
Modified residuei47Proline amideBy similarity1

Post-translational modificationi

Contains 3 disulfide bonds (By similarity). They are not added, since framework IV presents two different connectivities (I-V, II-III, IV-VI and I-III, II-V, IV-VI).By similarity

Keywords - PTMi

Amidation, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP0CAQ2

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP0CAQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 46Poly-Lys4

Domaini

The cysteine framework is IV (CC-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CAQ2-1 [UniParc]FASTAAdd to basket

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        10         20         30         40         50
SDFRNAAVHE RQKELVVTAT TTCCGYNPMT SCPRCMCDSS CNKKKKPGRR

ND
Length:52
Mass (Da):5,840
Last modified:June 16, 2009 - v1
Checksum:i17CDC2D7E1003B0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ311074 Genomic DNA Translation: ABD33866.1

Similar proteinsi

Entry informationi

Entry nameiCA43A_CONAH
AccessioniPrimary (citable) accession number: P0CAQ2
Secondary accession number(s): A3DT45, A3DT46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: May 23, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

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