P0CAQ1 (UBP16_EMENI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 16
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 16
Ubiquitin thioesterase 16
Ubiquitin-specific-processing protease 16

Gene names

Name:	ubp16
ORF Names:	AN11684

Organism

Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]

Taxonomic identifier

227321 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella › Emericella nidulans › mitosporic Emericella nidulans

Protein attributes

Sequence length	624 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Sequence similarities	Belongs to the peptidase C19 family.
Sequence caution	The sequence EAA63444.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene AN2873 has been split into 2 genes: AN2873 and AN11684.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 624	624	Ubiquitin carboxyl-terminal hydrolase 16		PRO_0000376621
Regions
	Compositional bias	438 – 577	140	Ser-rich
Sites
	Active site	55	1	Nucleophile By similarity
	Active site	424	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0CAQ1 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 0023FD124DCA2A7C	FASTA	624	69,446
	10 20 30 40 50 60 MQEKPTTVAA YAAGASLAAV ALFYVFGPNY TIDGDEAGGN RKKSIVGLSN PANDCFINSV 70 80 90 100 110 120 LQALAGLGDL RLYLIRELHR RELDGPEIYN QLPGPEEADQ LREKRPDRIR ELQQGTITRA 130 140 150 160 170 180 LKEMLDRLNE RPIYKKTISA RAFIQALEFA YRTRISRNQQ DAQEFLQIVA ERLSDEYHAG 190 200 210 220 230 240 VKARQRAEKS IEFNPYQERE EAPSEIEVRL DDGTENGLPA IIDTKLKEID NEYGFPFEGK 250 260 270 280 290 300 LESQIECQFC HYKYKPNQTS FVNLTLQVPQ RSSTTLNACF DGLLKTEYID DFRCDKCRLL 310 320 330 340 350 360 HAIEVKSNAL VKAGSATDRQ RLEAEIEKIQ LALSSDPENA LDGVTLPPAE LAPKRRIARH 370 380 390 400 410 420 MRITVFPKII AIHLSRSMFD RSGSTKNAAK VAFPERLPLG GILSQKWFKL LAIVCHKGSH 430 440 450 460 470 480 NSGHYESFRR NHLYPPYSTP SVFSSYAQSR AASENPSRVA SPRLPASSSS TEPPALNISP 490 500 510 520 530 540 PASTSTNSPL SLTPDSPSRP PSATDLKSPR PTTSSSRVSF QSTHSSSKQT ISPTSAARNS 550 560 570 580 590 600 SSLDTARLSS PASRSSLAER NASATDTEAS ASASLASRIR RRRKTADRWW RISDEKIKEC 610 620 KTSDVLGMQK EVYLLFYEIE KSGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]	"The 2008 update of the Aspergillus nidulans genome annotation: a community effort." Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G. Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACD01000051 Genomic DNA. Translation: EAA63444.1. Sequence problems. BN001306 Genomic DNA. No translation available.
RefSeq	XP_660477.1. XM_655385.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2873795.
KEGG	ani:AN2873.2.
Phylogenomic databases
KO	K11874.
OrthoDB	EOG4XD708.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBP16_EMENI

Accession

Primary (citable) accession number: P0CAQ1
Secondary accession number(s): Q5B9A7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	April 18, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program