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P0CAQ1

- UBP16_EMENI

UniProt

P0CAQ1 - UBP16_EMENI

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Protein

Ubiquitin carboxyl-terminal hydrolase 16

Gene

ubp16

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551NucleophilePROSITE-ProRule annotation
Active sitei424 – 4241Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 16 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 16
Ubiquitin thioesterase 16
Ubiquitin-specific-processing protease 16
Gene namesi
Name:ubp16
ORF Names:AN11684
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VI

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 624624Ubiquitin carboxyl-terminal hydrolase 16PRO_0000376621Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 620575USPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi438 – 577140Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

InParanoidiP0CAQ1.
KOiK11874.
OrthoDBiEOG7BCNMH.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CAQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEKPTTVAA YAAGASLAAV ALFYVFGPNY TIDGDEAGGN RKKSIVGLSN
60 70 80 90 100
PANDCFINSV LQALAGLGDL RLYLIRELHR RELDGPEIYN QLPGPEEADQ
110 120 130 140 150
LREKRPDRIR ELQQGTITRA LKEMLDRLNE RPIYKKTISA RAFIQALEFA
160 170 180 190 200
YRTRISRNQQ DAQEFLQIVA ERLSDEYHAG VKARQRAEKS IEFNPYQERE
210 220 230 240 250
EAPSEIEVRL DDGTENGLPA IIDTKLKEID NEYGFPFEGK LESQIECQFC
260 270 280 290 300
HYKYKPNQTS FVNLTLQVPQ RSSTTLNACF DGLLKTEYID DFRCDKCRLL
310 320 330 340 350
HAIEVKSNAL VKAGSATDRQ RLEAEIEKIQ LALSSDPENA LDGVTLPPAE
360 370 380 390 400
LAPKRRIARH MRITVFPKII AIHLSRSMFD RSGSTKNAAK VAFPERLPLG
410 420 430 440 450
GILSQKWFKL LAIVCHKGSH NSGHYESFRR NHLYPPYSTP SVFSSYAQSR
460 470 480 490 500
AASENPSRVA SPRLPASSSS TEPPALNISP PASTSTNSPL SLTPDSPSRP
510 520 530 540 550
PSATDLKSPR PTTSSSRVSF QSTHSSSKQT ISPTSAARNS SSLDTARLSS
560 570 580 590 600
PASRSSLAER NASATDTEAS ASASLASRIR RRRKTADRWW RISDEKIKEC
610 620
KTSDVLGMQK EVYLLFYEIE KSGS
Length:624
Mass (Da):69,446
Last modified:May 26, 2009 - v1
Checksum:i0023FD124DCA2A7C
GO

Sequence cautioni

The sequence EAA63444.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene AN2873 has been split into 2 genes: AN2873 and AN11684.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000051 Genomic DNA. Translation: EAA63444.1. Sequence problems.
BN001306 Genomic DNA. No translation available.
RefSeqiXP_660477.1. XM_655385.1.

Genome annotation databases

GeneIDi2873795.
KEGGiani:AN2873.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000051 Genomic DNA. Translation: EAA63444.1 . Sequence problems.
BN001306 Genomic DNA. No translation available.
RefSeqi XP_660477.1. XM_655385.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2873795.
KEGGi ani:AN2873.2.

Phylogenomic databases

InParanoidi P0CAQ1.
KOi K11874.
OrthoDBi EOG7BCNMH.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiUBP16_EMENI
AccessioniPrimary (citable) accession number: P0CAQ1
Secondary accession number(s): Q5B9A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3