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P0CAQ1 (UBP16_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 16

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 16
Ubiquitin thioesterase 16
Ubiquitin-specific-processing protease 16
Gene names
Name:ubp16
ORF Names:AN11684
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length624 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence caution

The sequence EAA63444.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene AN2873 has been split into 2 genes: AN2873 and AN11684.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 624624Ubiquitin carboxyl-terminal hydrolase 16
PRO_0000376621

Regions

Domain46 – 620575USP
Compositional bias438 – 577140Ser-rich

Sites

Active site551Nucleophile By similarity
Active site4241Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P0CAQ1 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 0023FD124DCA2A7C

FASTA62469,446
        10         20         30         40         50         60 
MQEKPTTVAA YAAGASLAAV ALFYVFGPNY TIDGDEAGGN RKKSIVGLSN PANDCFINSV 

        70         80         90        100        110        120 
LQALAGLGDL RLYLIRELHR RELDGPEIYN QLPGPEEADQ LREKRPDRIR ELQQGTITRA 

       130        140        150        160        170        180 
LKEMLDRLNE RPIYKKTISA RAFIQALEFA YRTRISRNQQ DAQEFLQIVA ERLSDEYHAG 

       190        200        210        220        230        240 
VKARQRAEKS IEFNPYQERE EAPSEIEVRL DDGTENGLPA IIDTKLKEID NEYGFPFEGK 

       250        260        270        280        290        300 
LESQIECQFC HYKYKPNQTS FVNLTLQVPQ RSSTTLNACF DGLLKTEYID DFRCDKCRLL 

       310        320        330        340        350        360 
HAIEVKSNAL VKAGSATDRQ RLEAEIEKIQ LALSSDPENA LDGVTLPPAE LAPKRRIARH 

       370        380        390        400        410        420 
MRITVFPKII AIHLSRSMFD RSGSTKNAAK VAFPERLPLG GILSQKWFKL LAIVCHKGSH 

       430        440        450        460        470        480 
NSGHYESFRR NHLYPPYSTP SVFSSYAQSR AASENPSRVA SPRLPASSSS TEPPALNISP 

       490        500        510        520        530        540 
PASTSTNSPL SLTPDSPSRP PSATDLKSPR PTTSSSRVSF QSTHSSSKQT ISPTSAARNS 

       550        560        570        580        590        600 
SSLDTARLSS PASRSSLAER NASATDTEAS ASASLASRIR RRRKTADRWW RISDEKIKEC 

       610        620 
KTSDVLGMQK EVYLLFYEIE KSGS 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACD01000051 Genomic DNA. Translation: EAA63444.1. Sequence problems.
BN001306 Genomic DNA. No translation available.
RefSeqXP_660477.1. XM_655385.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2873795.
KEGGani:AN2873.2.

Phylogenomic databases

KOK11874.
OrthoDBEOG7BCNMH.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP16_EMENI
AccessionPrimary (citable) accession number: P0CAQ1
Secondary accession number(s): Q5B9A7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: April 16, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries