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P0CAQ1

- UBP16_EMENI

UniProt

P0CAQ1 - UBP16_EMENI

Protein

Ubiquitin carboxyl-terminal hydrolase 16

Gene

ubp16

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei55 – 551NucleophilePROSITE-ProRule annotation
    Active sitei424 – 4241Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 16 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 16
    Ubiquitin thioesterase 16
    Ubiquitin-specific-processing protease 16
    Gene namesi
    Name:ubp16
    ORF Names:AN11684
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome VI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 624624Ubiquitin carboxyl-terminal hydrolase 16PRO_0000376621Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 620575USPAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi438 – 577140Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    KOiK11874.
    OrthoDBiEOG7BCNMH.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CAQ1-1 [UniParc]FASTAAdd to Basket

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    MQEKPTTVAA YAAGASLAAV ALFYVFGPNY TIDGDEAGGN RKKSIVGLSN    50
    PANDCFINSV LQALAGLGDL RLYLIRELHR RELDGPEIYN QLPGPEEADQ 100
    LREKRPDRIR ELQQGTITRA LKEMLDRLNE RPIYKKTISA RAFIQALEFA 150
    YRTRISRNQQ DAQEFLQIVA ERLSDEYHAG VKARQRAEKS IEFNPYQERE 200
    EAPSEIEVRL DDGTENGLPA IIDTKLKEID NEYGFPFEGK LESQIECQFC 250
    HYKYKPNQTS FVNLTLQVPQ RSSTTLNACF DGLLKTEYID DFRCDKCRLL 300
    HAIEVKSNAL VKAGSATDRQ RLEAEIEKIQ LALSSDPENA LDGVTLPPAE 350
    LAPKRRIARH MRITVFPKII AIHLSRSMFD RSGSTKNAAK VAFPERLPLG 400
    GILSQKWFKL LAIVCHKGSH NSGHYESFRR NHLYPPYSTP SVFSSYAQSR 450
    AASENPSRVA SPRLPASSSS TEPPALNISP PASTSTNSPL SLTPDSPSRP 500
    PSATDLKSPR PTTSSSRVSF QSTHSSSKQT ISPTSAARNS SSLDTARLSS 550
    PASRSSLAER NASATDTEAS ASASLASRIR RRRKTADRWW RISDEKIKEC 600
    KTSDVLGMQK EVYLLFYEIE KSGS 624
    Length:624
    Mass (Da):69,446
    Last modified:May 26, 2009 - v1
    Checksum:i0023FD124DCA2A7C
    GO

    Sequence cautioni

    The sequence EAA63444.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene AN2873 has been split into 2 genes: AN2873 and AN11684.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000051 Genomic DNA. Translation: EAA63444.1. Sequence problems.
    BN001306 Genomic DNA. No translation available.
    RefSeqiXP_660477.1. XM_655385.1.

    Genome annotation databases

    GeneIDi2873795.
    KEGGiani:AN2873.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000051 Genomic DNA. Translation: EAA63444.1 . Sequence problems.
    BN001306 Genomic DNA. No translation available.
    RefSeqi XP_660477.1. XM_655385.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2873795.
    KEGGi ani:AN2873.2.

    Phylogenomic databases

    KOi K11874.
    OrthoDBi EOG7BCNMH.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiUBP16_EMENI
    AccessioniPrimary (citable) accession number: P0CAQ1
    Secondary accession number(s): Q5B9A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3