P0CAP1 (MYZAP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myocardial zonula adherens protein

Alternative name(s):
GRINL1A upstream protein
Short name=Gup

Gene names

Name:	MYZAP
Synonyms:	MYOZAP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF By similarity. Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 By similarity.
Subunit structure	Interacts with DSP, MPRIP and TJP1/ZO1. Interaction with MPRIP inhibits the activation of transcription factor SRF By similarity. Interacts with GRIN1. Interacts with DYNLL1. Ref.7 Ref.8 Ref.9
Subcellular location	Cytoplasm › cytoskeleton By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm › myofibril › sarcomere › I band By similarity. Cytoplasm › myofibril › sarcomere › Z line By similarity. Cell junction. Note: Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin By similarity. Ref.7 Ref.9
Tissue specificity	Detected in heart, liver, skeletal muscle, placenta, small intestine, lung, prostate and testis. Ref.1 Ref.2
Miscellaneous	The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene.
Sequence similarities	Belongs to the MYZAP family.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Signal
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	I band Inferred from sequence or structural similarity. Source: UniProtKB Z disc Inferred from electronic annotation. Source: UniProtKB-SubCell cell junction Inferred from electronic annotation. Source: UniProtKB-SubCell cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell extrinsic to internal side of plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P0CAP1-1)

Also known as: Gcom8; Gup1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P0CAP1-2)

Also known as: Gcom2;

The sequence of this isoform differs from the canonical sequence as follows:
     435-466: SQTGRTREIVMPSRNYTPYTRVLELTMKKTLT → RRCKQSSQRKN

Isoform 3 (identifier: P0CAP1-3)

Also known as: Gcom13;

The sequence of this isoform differs from the canonical sequence as follows:
     108-138: Missing.

Isoform 4 (identifier: P0CAP1-4)

Also known as: Gcom9; Gup2;

The sequence of this isoform differs from the canonical sequence as follows:
     374-401: Missing.

Isoform 5 (identifier: P0CAP1-5)

Also known as: Gcom10;

The sequence of this isoform differs from the canonical sequence as follows:
     375-466: ESLKKKLQQK...LELTMKKTLT → MSHELFSRFSLRLFGR

Isoform 6 (identifier: P0CAP1-6)

Also known as: Gcom3;

The sequence of this isoform differs from the canonical sequence as follows:
     402-466: NNELQSRLDY...LELTMKKTLT → GRKGLKGRLKMSC

Isoform 7 (identifier: P0CAP1-7)

Also known as: Gcom4;

The sequence of this isoform differs from the canonical sequence as follows:
     402-466: NNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT → VTFSTK

Isoform 8 (identifier: P0CAP1-8)

Also known as: Gcom5;

The sequence of this isoform differs from the canonical sequence as follows:
     374-466: IESLKKKLQQ...LELTMKKTLT → VTFSTK

Isoform 9 (identifier: P0CAP1-9)

Also known as: Gcom6;

The sequence of this isoform differs from the canonical sequence as follows:
     108-138: Missing.
     374-401: Missing.
     435-466: SQTGRTREIVMPSRNYTPYTRVLELTMKKTLT → RQSRKFEKVLNEFVQLLPLPHHLLWAFGNVCWRRHFGLLQ

Isoform 10 (identifier: P0CAP1-10)

Also known as: Gcom11;

The sequence of this isoform differs from the canonical sequence as follows:
     107-175: Missing.

Isoform 11 (identifier: P0CAP1-11)

Also known as: Gcom1; GRINL1A complex locus protein 1;

The sequence of this isoform differs from the canonical sequence as follows:
     435-466: SQTGRTREIVMPSRNYTPYTRVLELTMKKTLT → RLPFRQNDSS...EDDDWSSDEF

Note: Based on a naturally occurring readthrough transcript which produces a MYZAP-POLR2M fusion protein.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

20

Potential

Chain

21 – 466

446

Myocardial zonula adherens protein

PRO_0000376013

Regions

Coiled coil

96 – 142

47

Potential

Coiled coil

174 – 418

245

Potential

Motif

424 – 425

2

Required for DYNLL1-binding

Amino acid modifications

Modified residue

5

1

Phosphothreonine By similarity

Modified residue

6

1

Phosphoserine By similarity

Natural variations

Alternative sequence

107 – 175

69

Missing in isoform 10.

VSP_037389

Alternative sequence

108 – 138

31

Missing in isoform 9 and isoform 3.

VSP_037390

Alternative sequence

374 – 466

93

IESLK…KKTLT → VTFSTK in isoform 8.

VSP_037391

Alternative sequence

374 – 401

28

Missing in isoform 4 and isoform 9.

VSP_037392

Alternative sequence

375 – 466

92

ESLKK…KKTLT → MSHELFSRFSLRLFGR in isoform 5.

VSP_037393

Alternative sequence

402 – 466

65

NNELQ…KKTLT → GRKGLKGRLKMSC in isoform 6.

VSP_037394

Alternative sequence

402 – 466

65

NNELQ…KKTLT → VTFSTK in isoform 7.

VSP_037395

Alternative sequence

435 – 466

32

SQTGR…KKTLT → RLPFRQNDSSSHCQKSGSPI SSEERRRRDKQHLDDITAAR LLPLHHMPTQLLSIEESLAL QKQQKQNYEEMQAKLAAQKL AERLNIKMRSYNPEGESSGR YREVRDEDDDWSSDEF in isoform 11.

VSP_037397

Alternative sequence

435 – 466

32

SQTGR…KKTLT → RRCKQSSQRKN in isoform 2.

VSP_037398

Alternative sequence

435 – 466

32

SQTGR…KKTLT → RQSRKFEKVLNEFVQLLPLP HHLLWAFGNVCWRRHFGLLQ in isoform 9.

VSP_037396

Natural variant

277

1

A → V. Ref.2 Ref.3
Corresponds to variant rs16977629 [ dbSNP | Ensembl ].

VAR_055453

Experimental info

Mutagenesis

436

1

Q → G: No effect on DYNLL1-binding; when associated with G-448. Ref.8

Mutagenesis

448

1

R → G: No effect on DYNLL1-binding; when associated with G-436. Ref.8

Mutagenesis

450

1

Y → G: No effect on DYNLL1-binding. Ref.8

Sequence conflict

144 – 146

3

Missing in ADA68358. Ref.2

Secondary structure

1

.

.

.

466

Helix Strand Turn

Details...

Beta strand

70 – 77

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Gcom8) (Gup1) [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 2A6B9C464B8641B4	FASTA	466	54,206
	10 20 30 40 50 60 MLRSTSTVTL LSGGAARTPG APSRRANVCR LRLTVPPESP VPEQCEKKIE RKEQLLDLSN 70 80 90 100 110 120 GEPTRKLPQG VVYGVVRRSD QNQQKEMVVY GWSTSQLKEE MNYIKDVRAT LEKVRKRMYG 130 140 150 160 170 180 DYDEMRQKIR QLTQELSVSH AQQEYLENHI QTQSSALDRF NAMNSALASD SIGLQKTLVD 190 200 210 220 230 240 VTLENSNIKD QIRNLQQTYE ASMDKLREKQ RQLEVAQVEN QLLKMKVESS QEANAEVMRE 250 260 270 280 290 300 MTKKLYSQYE EKLQEEQRKH SAEKEALLEE TNSFLKAIEE ANKKMQAAEI SLEEKDQRIG 310 320 330 340 350 360 ELDRLIERME KERHQLQLQL LEHETEMSGE LTDSDKERYQ QLEEASASLR ERIRHLDDMV 370 380 390 400 410 420 HCQQKKVKQM VEEIESLKKK LQQKQLLILQ LLEKISFLEG ENNELQSRLD YLTETQAKTE 430 440 450 460 VETREIGVGC DLLPSQTGRT REIVMPSRNY TPYTRVLELT MKKTLT
	Isoform 2 (Gcom2) [UniParc]. Checksum: B5586CECD9FE1E47	FASTA	445	51,824
	10 20 30 40 50 60 MLRSTSTVTL LSGGAARTPG APSRRANVCR LRLTVPPESP VPEQCEKKIE RKEQLLDLSN 70 80 90 100 110 120 GEPTRKLPQG VVYGVVRRSD QNQQKEMVVY GWSTSQLKEE MNYIKDVRAT LEKVRKRMYG 130 140 150 160 170 180 DYDEMRQKIR QLTQELSVSH AQQEYLENHI QTQSSALDRF NAMNSALASD SIGLQKTLVD 190 200 210 220 230 240 VTLENSNIKD QIRNLQQTYE ASMDKLREKQ RQLEVAQVEN QLLKMKVESS QEANAEVMRE 250 260 270 280 290 300 MTKKLYSQYE EKLQEEQRKH SAEKEALLEE TNSFLKAIEE ANKKMQAAEI SLEEKDQRIG 310 320 330 340 350 360 ELDRLIERME KERHQLQLQL LEHETEMSGE LTDSDKERYQ QLEEASASLR ERIRHLDDMV 370 380 390 400 410 420 HCQQKKVKQM VEEIESLKKK LQQKQLLILQ LLEKISFLEG ENNELQSRLD YLTETQAKTE 430 440 VETREIGVGC DLLPRRCKQS SQRKN
	Isoform 3 (Gcom13) [UniParc]. Checksum: 50120C5144877080	FASTA	435	50,381
	10 20 30 40 50 60 MLRSTSTVTL LSGGAARTPG APSRRANVCR LRLTVPPESP VPEQCEKKIE RKEQLLDLSN 70 80 90 100 110 120 GEPTRKLPQG VVYGVVRRSD QNQQKEMVVY GWSTSQLKEE MNYIKDVSHA QQEYLENHIQ 130 140 150 160 170 180 TQSSALDRFN AMNSALASDS IGLQKTLVDV TLENSNIKDQ IRNLQQTYEA SMDKLREKQR 190 200 210 220 230 240 QLEVAQVENQ LLKMKVESSQ EANAEVMREM TKKLYSQYEE KLQEEQRKHS AEKEALLEET 250 260 270 280 290 300 NSFLKAIEEA NKKMQAAEIS LEEKDQRIGE LDRLIERMEK ERHQLQLQLL EHETEMSGEL 310 320 330 340 350 360 TDSDKERYQQ LEEASASLRE RIRHLDDMVH CQQKKVKQMV EEIESLKKKL QQKQLLILQL 370 380 390 400 410 420 LEKISFLEGE NNELQSRLDY LTETQAKTEV ETREIGVGCD LLPSQTGRTR EIVMPSRNYT 430 PYTRVLELTM KKTLT
	Isoform 4 (Gcom9) (Gup2) [UniParc]. Checksum: C87A8E4F6C075852	FASTA	438	50,913
	10 20 30 40 50 60 MLRSTSTVTL LSGGAARTPG APSRRANVCR LRLTVPPESP VPEQCEKKIE RKEQLLDLSN 70 80 90 100 110 120 GEPTRKLPQG VVYGVVRRSD QNQQKEMVVY GWSTSQLKEE MNYIKDVRAT LEKVRKRMYG 130 140 150 160 170 180 DYDEMRQKIR QLTQELSVSH AQQEYLENHI QTQSSALDRF NAMNSALASD SIGLQKTLVD 190 200 210 220 230 240 VTLENSNIKD QIRNLQQTYE ASMDKLREKQ RQLEVAQVEN QLLKMKVESS QEANAEVMRE 250 260 270 280 290 300 MTKKLYSQYE EKLQEEQRKH SAEKEALLEE TNSFLKAIEE ANKKMQAAEI SLEEKDQRIG 310 320 330 340 350 360 ELDRLIERME KERHQLQLQL LEHETEMSGE LTDSDKERYQ QLEEASASLR ERIRHLDDMV 370 380 390 400 410 420 HCQQKKVKQM VEENNELQSR LDYLTETQAK TEVETREIGV GCDLLPSQTG RTREIVMPSR 430 NYTPYTRVLE LTMKKTLT
	Isoform 5 (Gcom10) [UniParc]. Checksum: 8188CE8C6E4A4EBF	FASTA	390	45,519
	10 20 30 40 50 60 MLRSTSTVTL LSGGAARTPG APSRRANVCR LRLTVPPESP VPEQCEKKIE RKEQLLDLSN 70 80 90 100 110 120 GEPTRKLPQG VVYGVVRRSD QNQQKEMVVY GWSTSQLKEE MNYIKDVRAT LEKVRKRMYG 130 140 150 160 170 180 DYDEMRQKIR QLTQELSVSH AQQEYLENHI QTQSSALDRF NAMNSALASD SIGLQKTLVD 190 200 210 220 230 240 VTLENSNIKD QIRNLQQTYE ASMDKLREKQ RQLEVAQVEN QLLKMKVESS QEANAEVMRE 250 260 270 280 290 300 MTKKLYSQYE EKLQEEQRKH SAEKEALLEE TNSFLKAIEE ANKKMQAAEI SLEEKDQRIG 310 320 330 340 350 360 ELDRLIERME KERHQLQLQL LEHETEMSGE LTDSDKERYQ QLEEASASLR ERIRHLDDMV 370 380 390 HCQQKKVKQM VEEIMSHELF SRFSLRLFGR
	Isoform 6 (Gcom3) [UniParc]. Checksum: A2F670D7A9752679	FASTA	414	48,149
	10 20 30 40 50 60 MLRSTSTVTL LSGGAARTPG APSRRANVCR LRLTVPPESP VPEQCEKKIE RKEQLLDLSN 70 80 90 100 110 120 GEPTRKLPQG VVYGVVRRSD QNQQKEMVVY GWSTSQLKEE MNYIKDVRAT LEKVRKRMYG 130 140 150 160 170 180 DYDEMRQKIR QLTQELSVSH AQQEYLENHI QTQSSALDRF NAMNSALASD SIGLQKTLVD 190 200 210 220 230 240 VTLENSNIKD QIRNLQQTYE ASMDKLREKQ RQLEVAQVEN QLLKMKVESS QEANAEVMRE 250 260 270 280 290 300 MTKKLYSQYE EKLQEEQRKH SAEKEALLEE TNSFLKAIEE ANKKMQAAEI SLEEKDQRIG 310 320 330 340 350 360 ELDRLIERME KERHQLQLQL LEHETEMSGE LTDSDKERYQ QLEEASASLR ERIRHLDDMV 370 380 390 400 410 HCQQKKVKQM VEEIESLKKK LQQKQLLILQ LLEKISFLEG EGRKGLKGRL KMSC
	Isoform 7 (Gcom4) [UniParc]. Checksum: 498D9F157C6B072E	FASTA	407	47,397
	10 20 30 40 50 60 MLRSTSTVTL LSGGAARTPG APSRRANVCR LRLTVPPESP VPEQCEKKIE RKEQLLDLSN 70 80 90 100 110 120 GEPTRKLPQG VVYGVVRRSD QNQQKEMVVY GWSTSQLKEE MNYIKDVRAT LEKVRKRMYG 130 140 150 160 170 180 DYDEMRQKIR QLTQELSVSH AQQEYLENHI QTQSSALDRF NAMNSALASD SIGLQKTLVD 190 200 210 220 230 240 VTLENSNIKD QIRNLQQTYE ASMDKLREKQ RQLEVAQVEN QLLKMKVESS QEANAEVMRE 250 260 270 280 290 300 MTKKLYSQYE EKLQEEQRKH SAEKEALLEE TNSFLKAIEE ANKKMQAAEI SLEEKDQRIG 310 320 330 340 350 360 ELDRLIERME KERHQLQLQL LEHETEMSGE LTDSDKERYQ QLEEASASLR ERIRHLDDMV 370 380 390 400 HCQQKKVKQM VEEIESLKKK LQQKQLLILQ LLEKISFLEG EVTFSTK
	Isoform 8 (Gcom5) [UniParc]. Checksum: 981B1A2DA4E222F9	FASTA	379	44,104
	10 20 30 40 50 60 MLRSTSTVTL LSGGAARTPG APSRRANVCR LRLTVPPESP VPEQCEKKIE RKEQLLDLSN 70 80 90 100 110 120 GEPTRKLPQG VVYGVVRRSD QNQQKEMVVY GWSTSQLKEE MNYIKDVRAT LEKVRKRMYG 130 140 150 160 170 180 DYDEMRQKIR QLTQELSVSH AQQEYLENHI QTQSSALDRF NAMNSALASD SIGLQKTLVD 190 200 210 220 230 240 VTLENSNIKD QIRNLQQTYE ASMDKLREKQ RQLEVAQVEN QLLKMKVESS QEANAEVMRE 250 260 270 280 290 300 MTKKLYSQYE EKLQEEQRKH SAEKEALLEE TNSFLKAIEE ANKKMQAAEI SLEEKDQRIG 310 320 330 340 350 360 ELDRLIERME KERHQLQLQL LEHETEMSGE LTDSDKERYQ QLEEASASLR ERIRHLDDMV 370 HCQQKKVKQM VEEVTFSTK
	Isoform 9 (Gcom6) [UniParc]. Checksum: F58E12AF16EE9267	FASTA	415	48,231
	10 20 30 40 50 60 MLRSTSTVTL LSGGAARTPG APSRRANVCR LRLTVPPESP VPEQCEKKIE RKEQLLDLSN 70 80 90 100 110 120 GEPTRKLPQG VVYGVVRRSD QNQQKEMVVY GWSTSQLKEE MNYIKDVSHA QQEYLENHIQ 130 140 150 160 170 180 TQSSALDRFN AMNSALASDS IGLQKTLVDV TLENSNIKDQ IRNLQQTYEA SMDKLREKQR 190 200 210 220 230 240 QLEVAQVENQ LLKMKVESSQ EANAEVMREM TKKLYSQYEE KLQEEQRKHS AEKEALLEET 250 260 270 280 290 300 NSFLKAIEEA NKKMQAAEIS LEEKDQRIGE LDRLIERMEK ERHQLQLQLL EHETEMSGEL 310 320 330 340 350 360 TDSDKERYQQ LEEASASLRE RIRHLDDMVH CQQKKVKQMV EENNELQSRL DYLTETQAKT 370 380 390 400 410 EVETREIGVG CDLLPRQSRK FEKVLNEFVQ LLPLPHHLLW AFGNVCWRRH FGLLQ
	Isoform 10 (Gcom11) [UniParc]. Checksum: 9F313D3BC8F5CBEF	FASTA	397	46,224
	10 20 30 40 50 60 MLRSTSTVTL LSGGAARTPG APSRRANVCR LRLTVPPESP VPEQCEKKIE RKEQLLDLSN 70 80 90 100 110 120 GEPTRKLPQG VVYGVVRRSD QNQQKEMVVY GWSTSQLKEE MNYIKDKTLV DVTLENSNIK 130 140 150 160 170 180 DQIRNLQQTY EASMDKLREK QRQLEVAQVE NQLLKMKVES SQEANAEVMR EMTKKLYSQY 190 200 210 220 230 240 EEKLQEEQRK HSAEKEALLE ETNSFLKAIE EANKKMQAAE ISLEEKDQRI GELDRLIERM 250 260 270 280 290 300 EKERHQLQLQ LLEHETEMSG ELTDSDKERY QQLEEASASL RERIRHLDDM VHCQQKKVKQ 310 320 330 340 350 360 MVEEIESLKK KLQQKQLLIL QLLEKISFLE GENNELQSRL DYLTETQAKT EVETREIGVG 370 380 390 CDLLPSQTGR TREIVMPSRN YTPYTRVLEL TMKKTLT
	Isoform 11 (Gcom1) (GRINL1A complex locus protein 1) [UniParc]. Checksum: 6A30A8464C3EA8CB	FASTA	550	64,046
	10 20 30 40 50 60 MLRSTSTVTL LSGGAARTPG APSRRANVCR LRLTVPPESP VPEQCEKKIE RKEQLLDLSN 70 80 90 100 110 120 GEPTRKLPQG VVYGVVRRSD QNQQKEMVVY GWSTSQLKEE MNYIKDVRAT LEKVRKRMYG 130 140 150 160 170 180 DYDEMRQKIR QLTQELSVSH AQQEYLENHI QTQSSALDRF NAMNSALASD SIGLQKTLVD 190 200 210 220 230 240 VTLENSNIKD QIRNLQQTYE ASMDKLREKQ RQLEVAQVEN QLLKMKVESS QEANAEVMRE 250 260 270 280 290 300 MTKKLYSQYE EKLQEEQRKH SAEKEALLEE TNSFLKAIEE ANKKMQAAEI SLEEKDQRIG 310 320 330 340 350 360 ELDRLIERME KERHQLQLQL LEHETEMSGE LTDSDKERYQ QLEEASASLR ERIRHLDDMV 370 380 390 400 410 420 HCQQKKVKQM VEEIESLKKK LQQKQLLILQ LLEKISFLEG ENNELQSRLD YLTETQAKTE 430 440 450 460 470 480 VETREIGVGC DLLPRLPFRQ NDSSSHCQKS GSPISSEERR RRDKQHLDDI TAARLLPLHH 490 500 510 520 530 540 MPTQLLSIEE SLALQKQQKQ NYEEMQAKLA AQKLAERLNI KMRSYNPEGE SSGRYREVRD 550 EDDDWSSDEF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes." Roginski R.S., Mohan Raj B.K., Birditt B., Rowen L. Genomics 84:265-276(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10 AND 11), TISSUE SPECIFICITY. Tissue: Brain and Lung.
[2]	"Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo." Seeger T.S., Frank D., Rohr C., Will R., Just S., Grund C., Lyon R., Luedde M., Koegl M., Sheikh F., Rottbauer W., Franke W.W., Katus H.A., Olson E.N., Frey N. Circ. Res. 106:880-890(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-277, TISSUE SPECIFICITY.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-277. Tissue: Heart.
[4]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain cortex.
[7]	"GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity." Roginski R.S., Goubaeva F., Mikami M., Fried-Cassorla E., Nair M.R., Yang J. NeuroReport 19:1721-1726(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GRIN1, SUBCELLULAR LOCATION.
[8]	"Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A." Garcia-Mayoral M.F., Martinez-Moreno M., Albar J.P., Rodriguez-Crespo I., Bruix M. FEBS J. 277:2340-2350(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DYNLL1, MUTAGENESIS OF GLN-436; ARG-448 AND TYR-450.
[9]	"Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration." Huo L., Wen W., Wang R., Kam C., Xia J., Feng W., Zhang M. EMBO J. 30:665-678(2011) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 70-79 IN COMPLEX WITH TJP1, SUBCELLULAR LOCATION, INTERACTION WITH TJP1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY207007 mRNA. Translation: AAO39707.1.
AY207459 mRNA. Translation: AAP41548.1.
AY208913 mRNA. Translation: AAP41549.1.
AY237639 mRNA. Translation: AAP75897.1.
AY331564 mRNA. Translation: AAQ76825.1.
AY333779 mRNA. Translation: AAQ76826.1.
AY334560 mRNA. Translation: AAQ76827.1.
AY334561 mRNA. Translation: AAQ76828.1.
AY334562 mRNA. Translation: AAQ76829.1.
AY341345 mRNA. Translation: AAQ76831.1.
AY353056 mRNA. Translation: AAQ76832.1.
AY353057 mRNA. Translation: AAQ76833.1.
AY353058 mRNA. Translation: AAQ76834.1.
AY353060 mRNA. Translation: AAQ76836.1.
FJ970029 mRNA. Translation: ADA68358.1.
AK055535 mRNA. Translation: BAB70944.1.
AC025271 Genomic DNA. No translation available.
AC090651 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77522.1.
CH471082 Genomic DNA. Translation: EAW77527.1.
BC101645 mRNA. Translation: AAI01646.1.
BC112148 mRNA. Translation: AAI12149.1.

IPI

IPI00427956.
IPI00455411.
IPI00455420.
IPI00550577.
IPI00550600.
IPI00619933.
IPI00619949.
IPI00887423.
IPI00887584.
IPI00887916.
IPI00889014.

RefSeq

NP_001018100.1. NM_001018090.4.
NP_001018101.1. NM_001018091.4.
NP_001018110.1. NM_001018100.3.
NP_001018112.1. NM_001018102.1.
NP_689664.3. NM_152451.6.

UniGene

Hs.437256.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2KXS	NMR	-	A	70-79	[»]

ProteinModelPortal

P0CAP1.

SMR

P0CAP1. Positions 352-377.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-1370040.

PTM databases

PhosphoSite

P0CAP1.

Polymorphism databases

DMDM

238064959.

Proteomic databases

PaxDb

P0CAP1.

PRIDE

P0CAP1.

Protocols and materials databases

DNASU

81488.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000267853; ENSP00000267853; ENSG00000263155.
ENST00000380565; ENSP00000369939; ENSG00000263155.

GeneID

100820829.
145781.
81488.

KEGG

hsa:100820829.
hsa:145781.
hsa:81488.

UCSC

uc002aei.3. human.
uc002aej.3. human.
uc002aem.3. human.
uc002aeo.3. human.

Organism-specific databases

CTD

100820829.
145781.
81488.

GeneCards

GC15P057887.

HGNC

HGNC:43444. MYZAP.

HPA

HPA039827.

MIM

614071. gene.

neXtProt

NX_P0CAP1.

PharmGKB

PA28986.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG81402.

OMA

MEKERHQ.

PhylomeDB

P0CAP1.

Gene expression databases

ArrayExpress

P0CAP1.

Bgee

P0CAP1.

Genevestigator

P0CAP1.

Family and domain databases

ProtoNet

Search...

Other

ChiTaRS

MYZAP. human.

EvolutionaryTrace

P0CAP1.

NextBio

71714.

SOURCE

Search...

Entry information

Entry name

MYZAP_HUMAN

Accession

Primary (citable) accession number: P0CAP1
Secondary accession number(s): D2E9U7 , Q6EER8, Q6EES2, Q6EEV3, Q6EF00, Q6EF01, Q6EF02, Q6EF46, Q6EFN8, Q6EM48, Q6K046, Q6K050, Q6K051, Q6ZQZ3, Q8NC58, Q8NCF3, Q96DI5, Q96JB7, Q96NF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.