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Protein

B-cell antigen receptor complex-associated protein alpha chain

Gene

CD79A

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei218Required for binding to BLNKBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-CFA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell antigen receptor complex-associated protein alpha chain
Alternative name(s):
Ig-alpha
CD_antigen: CD79a
Gene namesi
Name:CD79A
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 151ExtracellularSequence analysisAdd BLAST119
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 236CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000037377733 – 236B-cell antigen receptor complex-associated protein alpha chainAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 109PROSITE-ProRule annotation
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127Interchain (with beta chain)PROSITE-ProRule annotation
Modified residuei196Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotationBy similarity1
Modified residuei207PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei212Asymmetric dimethylarginine; by PRMT1By similarity1
Modified residuei218Phosphotyrosine; by Tyr-kinasesPROSITE-ProRule annotationBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases, including LYN, is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation (By similarity).By similarity
Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP0CAN6.

Expressioni

Gene expression databases

BgeeiENSCAFG00000004980.

Interactioni

Subunit structurei

Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-207, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007407.

Structurei

3D structure databases

ProteinModelPortaliP0CAN6.
SMRiP0CAN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 122Ig-like C2-typeAdd BLAST90
Domaini185 – 213ITAMPROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV8X. Eukaryota.
ENOG4111VIC. LUCA.
GeneTreeiENSGT00510000049127.
HOGENOMiHOG000074307.
InParanoidiP0CAN6.
KOiK06506.
OMAiEGTKNRI.
OrthoDBiEOG091G10RQ.
TreeFamiTF336032.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR003110. Phos_immunorcpt_sig_ITAM.
PfamiView protein in Pfam
PF00047. ig. 1 hit.
PF02189. ITAM. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00077. ITAM. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CAN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGGPGLLQA LCATTFLLFL ISAGGLGPGS QALWVDGGPP SMTVSLGETA
60 70 80 90 100
RLQCLHNRSR LSSKLNITWW RVLQGNATWP DIFLSYGKGP NGELTIDTVN
110 120 130 140 150
KSHMGMYRCQ VEEKDLNQKI LSSQQSCGTY LRVRERLPRP FLDMGEGTKN
160 170 180 190 200
NIITAEGIIL LFCAVVPGTL LLFRKRWQNM KFGVDAQDDY EDENLYEGLN
210 220 230
LDDCSMYEDI SRGLQGTYQD VGSLHIGDGD VQLEKP
Length:236
Mass (Da):26,120
Last modified:May 5, 2009 - v1
Checksum:iE24C3DDF97119B7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DN272794 mRNA. No translation available.
DN352654 mRNA. No translation available.
AAEX02033438 Genomic DNA. No translation available.
RefSeqiNP_001300763.1. NM_001313834.1.

Genome annotation databases

EnsembliENSCAFT00000008000; ENSCAFP00000007407; ENSCAFG00000004980.
GeneIDi484483.
KEGGicfa:484483.

Similar proteinsi

Entry informationi

Entry nameiCD79A_CANLF
AccessioniPrimary (citable) accession number: P0CAN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: August 30, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome