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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

Pret-143

Organism
African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The viral dUTPase may play a role in lowering the dUTP concentration in natural infections to minimize misincorporation of deoxyuridine into the viral DNA and ensure the fidelity of genome replication.By similarity

Miscellaneous

Expressed early and late in the infection.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Ordered Locus Names:Pret-143
OrganismiAfrican swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)
Taxonomic identifieri561443 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAsfarviridaeAsfivirus
Virus hostiOrnithodoros (relapsing fever ticks) [TaxID: 6937]
Phacochoerus aethiopicus (Warthog) [TaxID: 85517]
Phacochoerus africanus (Warthog) [TaxID: 41426]
Potamochoerus larvatus (Bushpig) [TaxID: 273792]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000000859 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003731341 – 165Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST165

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0C9C3.
SMRiP0C9C3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Phylogenomic databases

OrthoDBiVOG090000V4.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
InterProiView protein in InterPro
IPR029054. dUTPase-like.
IPR036157. dUTPase-like_sf.
IPR033704. dUTPase_trimeric.
PfamiView protein in Pfam
PF00692. dUTPase. 1 hit.
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C9C3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATNFFIQPI TEEAEAYYPP SVITNKRKDL GVDVYCCSDL VLQPGLNIVR
60 70 80 90 100
LHIKVACEHM GKKCGFKIMA RSSMCTYERL LILANGIGLI DPGYVGELML
110 120 130 140 150
KIINLGDTPV QIWAKECLVQ LVAQGDHVPD HINILKRNQI FPLFAPTPRG
160
EGRFGSTGEA GIMRT
Length:165
Mass (Da):18,289
Last modified:May 5, 2009 - v1
Checksum:i7BAAB5C34D8D26F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY261363 Genomic DNA. No translation available.

Similar proteinsi

Entry informationi

Entry nameiDUTP_ASFP4
AccessioniPrimary (citable) accession number: P0C9C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: October 25, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families