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P0C957 (PLB1_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase 1

EC=3.1.1.5
Alternative name(s):
Phospholipase B 1
Gene names
Name:plb1
ORF Names:AFUA_4G08720
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length633 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the release of fatty acids from lysophospholipids.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity.

Induction

Induced by lecithin. Ref.1

Post-translational modification

The GPI-like anchor contains a phosphoceramide lipid group By similarity.

Sequence similarities

Belongs to the lysophospholipase family.

Contains 1 PLA2c domain.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentCell membrane
Membrane
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
GPI-anchor
Lipoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processphospholipid catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentanchored component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 609589Lysophospholipase 1
PRO_0000245555
Propeptide610 – 63324Removed in mature form Potential
PRO_0000245556

Regions

Domain47 – 594548PLA2c

Amino acid modifications

Lipidation6091GPI-like-anchor amidated serine Potential
Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation2461N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential
Glycosylation3291N-linked (GlcNAc...) Potential
Glycosylation3581N-linked (GlcNAc...) Potential
Glycosylation3971N-linked (GlcNAc...) Potential
Glycosylation4501N-linked (GlcNAc...) Potential
Glycosylation4631N-linked (GlcNAc...) Potential
Glycosylation4691N-linked (GlcNAc...) Potential
Glycosylation4971N-linked (GlcNAc...) Potential
Glycosylation5001N-linked (GlcNAc...) Potential
Glycosylation5211N-linked (GlcNAc...) Potential
Glycosylation5491N-linked (GlcNAc...) Potential
Glycosylation5551N-linked (GlcNAc...) Potential
Glycosylation5941N-linked (GlcNAc...) Potential

Natural variations

Natural variant4981S → N in strain: ATCC 90240 / AF-10. Ref.1
Natural variant590 – 5934DGSL → NGTV in strain: ATCC 90240 / AF-10.

Sequences

Sequence LengthMass (Da)Tools
P0C957 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 277A47E29FD74796

FASTA63368,144
        10         20         30         40         50         60 
MKTTTVACAV AGLLFSCVSG APDPVHVEIQ QRALPNAPDG YTPSTVGCPA SRPTIRSAAS 

        70         80         90        100        110        120 
LSPNETSWLE TRRGKTTSAM KDFFNHVKIQ DFDAAGYIDR HSSNSSDLPN IGIAVSGGGY 

       130        140        150        160        170        180 
RALMNGAGAI KAFDSRTPNS TSAGQLGGLL QSATYLSGLS GGSWLVGSIY INNFTTISAL 

       190        200        210        220        230        240 
QTHQKGTVWQ FQNSIFEGPD GGSIQILDSA TYYRDISNAV SGKSDAGYPT SITDYWGRAL 

       250        260        270        280        290        300 
SYQMINATNG GPSYTWSSIA LTDAFQKAEM PMPLVVADGR YPGELLISSN ATVYEFNPWE 

       310        320        330        340        350        360 
FGTFDPTVFG FAPLEYLGTK FNGGSVPSNE SCVRGFDNVG FVMGTSSTLF NQFLLQINST 

       370        380        390        400        410        420 
ALPDWLKSVF TDILKDIGEN DEDIAQYAPN PFYHFSNTTN PSAAELELDL VDGGEDLQNI 

       430        440        450        460        470        480 
PLHPLIQPER HVDVIFAVDS SADTTYSWPN GTALVATYER SLNSSGIANG TSFPAIPDQN 

       490        500        510        520        530        540 
TFVNKGLNTR PTFFGCNSSN TTGPSPLIVY LPNYPYTAYS NFSTFQPDYT EQERDSTILN 

       550        560        570        580        590        600 
GYDVVTMGNS TRDGNWSTCV GCAILSRSLE RTNTNVPEIC KQCFQRYCWD GSLNSTTPAG 

       610        620        630 
YEPVTILDSA ASGIIPSIST VAMAVVFAAW TIF 

« Hide

References

« Hide 'large scale' references
[1]"Characterisation and expression of phospholipases B from the opportunistic fungus Aspergillus fumigatus."
Shen D.-K., Noodeh A.D., Kazemi A., Grillot R., Robson G.D., Brugere J.-F.
FEMS Microbiol. Lett. 239:87-93(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-498 AND 590-ASN--VAL-593, INDUCTION.
Strain: ATCC 90240 / AF-10.
[2]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF223004 Genomic DNA. Translation: AAF64038.2.
AAHF01000005 Genomic DNA. Translation: EAL89914.1.
RefSeqXP_751952.1. XM_746859.1.

3D structure databases

ProteinModelPortalP0C957.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome8989. Asp f LPL1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00008211; CADAFUAP00008211; CADAFUAG00008211.
GeneID3509318.
KEGGafm:AFUA_4G08720.

Phylogenomic databases

eggNOGNOG271081.
HOGENOMHOG000189547.
KOK13333.
OMAFGTFDPT.
OrthoDBEOG7N37NC.

Family and domain databases

InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMSSF52151. SSF52151. 1 hit.
PROSITEPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLB1_ASPFU
AccessionPrimary (citable) accession number: P0C957
Secondary accession number(s): Q4WPC0, Q6U820, Q9P8P5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families