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Protein

Lysophospholipase 1

Gene

plb1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 1 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 1
Gene namesi
Name:plb1
ORF Names:AFUA_4G08720
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiFungiDB:Afu4g08720.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Protein family/group databases

Allergomei8989. Asp f LPL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000024555521 – 609Lysophospholipase 1Add BLAST589
PropeptideiPRO_0000245556610 – 633Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi358N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi450N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi463N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi521N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi549N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi555N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi594N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi609GPI-like-anchor amidated serineSequence analysis1

Post-translational modificationi

The GPI-like anchor contains a phosphoceramide lipid group.By similarity

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Inductioni

Induced by lecithin.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00006407.

Structurei

3D structure databases

ProteinModelPortaliP0C957.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 594PLA2cPROSITE-ProRule annotationAdd BLAST548

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189547.
InParanoidiP0C957.
KOiK13333.
OMAiTYSWPNG.
OrthoDBiEOG092C2IZ9.

Family and domain databases

InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
PfamiView protein in Pfam
PF01735. PLA2_B. 1 hit.
SMARTiView protein in SMART
SM00022. PLAc. 1 hit.
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiView protein in PROSITE
PS51210. PLA2C. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTTTVACAV AGLLFSCVSG APDPVHVEIQ QRALPNAPDG YTPSTVGCPA
60 70 80 90 100
SRPTIRSAAS LSPNETSWLE TRRGKTTSAM KDFFNHVKIQ DFDAAGYIDR
110 120 130 140 150
HSSNSSDLPN IGIAVSGGGY RALMNGAGAI KAFDSRTPNS TSAGQLGGLL
160 170 180 190 200
QSATYLSGLS GGSWLVGSIY INNFTTISAL QTHQKGTVWQ FQNSIFEGPD
210 220 230 240 250
GGSIQILDSA TYYRDISNAV SGKSDAGYPT SITDYWGRAL SYQMINATNG
260 270 280 290 300
GPSYTWSSIA LTDAFQKAEM PMPLVVADGR YPGELLISSN ATVYEFNPWE
310 320 330 340 350
FGTFDPTVFG FAPLEYLGTK FNGGSVPSNE SCVRGFDNVG FVMGTSSTLF
360 370 380 390 400
NQFLLQINST ALPDWLKSVF TDILKDIGEN DEDIAQYAPN PFYHFSNTTN
410 420 430 440 450
PSAAELELDL VDGGEDLQNI PLHPLIQPER HVDVIFAVDS SADTTYSWPN
460 470 480 490 500
GTALVATYER SLNSSGIANG TSFPAIPDQN TFVNKGLNTR PTFFGCNSSN
510 520 530 540 550
TTGPSPLIVY LPNYPYTAYS NFSTFQPDYT EQERDSTILN GYDVVTMGNS
560 570 580 590 600
TRDGNWSTCV GCAILSRSLE RTNTNVPEIC KQCFQRYCWD GSLNSTTPAG
610 620 630
YEPVTILDSA ASGIIPSIST VAMAVVFAAW TIF
Length:633
Mass (Da):68,144
Last modified:May 5, 2009 - v1
Checksum:i277A47E29FD74796
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti498S → N in strain: ATCC 90240 / AF-10. 1 Publication1
Natural varianti590 – 593DGSL → NGTV in strain: ATCC 90240 / AF-10. 4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223004 Genomic DNA. Translation: AAF64038.2.
AAHF01000005 Genomic DNA. Translation: EAL89914.1.
RefSeqiXP_751952.1. XM_746859.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00008211; CADAFUAP00008211; CADAFUAG00008211.
GeneIDi3509318.
KEGGiafm:AFUA_4G08720.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPLB1_ASPFU
AccessioniPrimary (citable) accession number: P0C957
Secondary accession number(s): Q4WPC0, Q6U820, Q9P8P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: July 5, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families