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Protein

Regulator of telomere elongation helicase 1

Gene

rtel1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi145 – 1451Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi163 – 1631Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi172 – 1721Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi207 – 2071Iron-sulfur (4Fe-4S)UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi42 – 498ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

4Fe-4S, ATP-binding, DNA-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of telomere elongation helicase 1UniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:rtel1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11771177Regulator of telomere elongation helicase 1PRO_0000370614Add
BLAST

Proteomic databases

PaxDbiP0C928.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000105420.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 302296Helicase ATP-bindingUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi151 – 16717Nuclear localization signalUniRule annotationAdd
BLAST
Motifi250 – 2534DEAH box
Motifi883 – 8897Nuclear localization signalUniRule annotation

Sequence similaritiesi

Belongs to the helicase family. RAD3/XPD subfamily.UniRule annotation
Contains 1 helicase ATP-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1132. Eukaryota.
COG1199. LUCA.
HOGENOMiHOG000007558.
InParanoidiP0C928.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_03065. RTEL1. 1 hit.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR030845. RTEL1.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 9 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVIKLKGIN VDFPFTPYPC QEDYMSKVIE CLQKKVNGVL ESPTGTGKTL
60 70 80 90 100
CLLCSTLAWR DHFKDTISAR KITERMGGAE LFADRPMSSW GTAATDGDTP
110 120 130 140 150
TYYTDIPKII YASRTHSQLT QVVNELKNTS YRPKICVLGS REQLCINQEV
160 170 180 190 200
MRHESNHIKV HMCRAKVSSR SCIFYNNVDE KSTDKEIVNS ILDVEDLVKT
210 220 230 240 250
GKKQRVCPYY LSRSLKQHAD VIFMPYNYLL DPKSRRAHNI ELKGAVVIFD
260 270 280 290 300
EAHNVEKMCE ESTSFDLTPH DLISAIEAVD RLLREQASDI SKADSAEDFN
310 320 330 340 350
VESLNSGLKM DITTIAKVKQ ILMDLETAIN DFEMPANNQG ITKPGSFIFE
360 370 380 390 400
LFEMANVNSK TKTETVEAME QITGYLAGRP GVFLNTSGLQ KVADIIQLVF
410 420 430 440 450
VAEPAEGSKK SQTGNSLKEF KVHIHPDNSN FKKKQITDVW ASSSTKKQGN
460 470 480 490 500
VLSYWCFSPG FSMQELLRQE VRCIILTSGT LSPLSSFTCE MQIPFPVSLE
510 520 530 540 550
NPHVIQRDQI FVSIIEKGPD GVQLSTAFDR RFVPENMSSM GNTLVNLSRV
560 570 580 590 600
VPHGLLVFFP SYPVMDKTLE FWRAKGHADR IENVKPMFVE PRGKGTFTEV
610 620 630 640 650
IDGYYGKVDD PNSSGGSFFA VCRGKASEGL DFADTYGRGV VITGLPFPPR
660 670 680 690 700
MDPRVVLKMQ YLDEMCRNKI SGVKYLTGQE WYRQQASRAV NQAIGRVIRH
710 720 730 740 750
REDYGAIFLC DHRFKSADAR NQLPSWVRPY VKIYDGFGTM VRDVAQFFRT
760 770 780 790 800
AQKTRPVPVK KGKAEGHENQ ADTRLLNTGS SCLTKSVWPS DIYQKAKTLD
810 820 830 840 850
AHVPSLKRRK LDSEEHSGRE GAARLCIQYE MEMTSKRKPV SLLDALDDTT
860 870 880 890 900
DKEEREDTMV GEERASHLST LSLQHDKRLD DESRGGKRKI KVVQERETVT
910 920 930 940 950
SHTAKTGKAF MMELRRCLSH ENFKLIMEAL QSYKTADNLN NLLATVAEPL
960 970 980 990 1000
IQDHNTHSLL RGLYQFIRPH HKKEYDERCL ELTGEGCGYK QEHSLSREEK
1010 1020 1030 1040 1050
EALRHNSVKA EIPPVNPPIE QLNSSRLLNQ GGSHLGTIQL NGGEVNVRSE
1060 1070 1080 1090 1100
EQKPQTSIKE GPSCSSLLSD IKQAIGAEKT RQMFSALQAY KTSNNYEQMV
1110 1120 1130 1140 1150
STVVSLLTER DEDIALLERL SVLIRPQHRK QFGELLKSLT GNDSAVVQDS
1160 1170
DIGSSQQLSY LEERLNARYR PSFHECC
Length:1,177
Mass (Da):132,804
Last modified:May 5, 2009 - v1
Checksum:iCA613CA7DD45A138
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX004876 Genomic DNA. No translation available.
RefSeqiXP_009304167.1. XM_009305892.1.
UniGeneiDr.87074.

Genome annotation databases

GeneIDi503732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX004876 Genomic DNA. No translation available.
RefSeqiXP_009304167.1. XM_009305892.1.
UniGeneiDr.87074.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000105420.

Proteomic databases

PaxDbiP0C928.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi503732.

Organism-specific databases

CTDi51750.

Phylogenomic databases

eggNOGiKOG1132. Eukaryota.
COG1199. LUCA.
HOGENOMiHOG000007558.
InParanoidiP0C928.

Miscellaneous databases

PROiP0C928.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_03065. RTEL1. 1 hit.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR030845. RTEL1.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 9 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTEL1_DANRE
AccessioniPrimary (citable) accession number: P0C928
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: May 11, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.