Reviewed, UniProtKB/Swiss-Prot P0C909 (KAX3B_ODODO)

Names and origin

Protein names	Recommended name:     Potassium channel toxin alpha-KTx 3.11 Alternative name(s):     OdK2
Organism	Odontobuthus doriae (Scorpion)
Taxonomic identifier	342590 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Odontobuthus

Protein attributes

Sequence length	38 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Blocks the voltage-gated potassium channel Kv1.3/KCNA3, with an IC50 of 7.2 nM. Has no activity on other channels tested (Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.4/KCNA4, Kv1.5/ KCNA5, Kv1.6/KCNA6, Shaker/Sh and hERG/KCNH). Ref.1
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 3 subfamily.
Mass spectrometry	Molecular mass is 4072 Da from positions 1 - 38. Determined by MALDI. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 38	38	Potassium channel toxin alpha-KTx 3.11		PRO_0000368017
Amino acid modifications
	Disulfide bond	8 ↔ 28		By similarity
	Disulfide bond	14 ↔ 33		By similarity
	Disulfide bond	18 ↔ 35		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C909-1 [UniParc]. Last modified April 14, 2009. Version 1. Checksum: 0ACB1B1D168D2174	FASTA	38	4,083
	10 20 30 GVPTDVKCRG SPQCIQPCKD AGMRFGKCMN GKCHCTPK

References

[1]

"OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae." Abdel-Mottaleb Y., Vandendriessche T., Clynen E., Landuyt B., Jalali A., Vatanpour H., Schoofs L., Tytgat J. Toxicon 51:1424-1430(2008) [PubMed: 18471844] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY. Tissue: Venom.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR001947. Scorpion_toxinS. [Graphical view]
Pfam	PF00451. Toxin_2. 1 hit. [Graphical view]
PRINTS	PR00286. CHARYBDTOXIN.
ProDom	PD003586. Scorpion_toxinS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAX3B_ODODO

Accession

Primary (citable) accession number: P0C909

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 14, 2009
Last modified:	November 24, 2009
This is version 5 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)