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P0C908

- KAX3A_BUTOS

UniProt

P0C908 - KAX3A_BUTOS

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Protein

Potassium channel toxin alpha-KTx 3.10

Gene
N/A
Organism
Buthus occitanus israelis (Common yellow scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits insect potassium channel. Is at least a hundred-fold more potent against the Drosophila Shaker channel than towards its mammalian homologs Kv1.1/KCNA1 and Kv1.3/KCNA3.1 Publication

GO - Molecular functioni

  1. ion channel inhibitor activity Source: InterPro

GO - Biological processi

  1. defense response Source: InterPro
  2. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 3.10
Alternative name(s):
BoiTx1
OrganismiButhus occitanus israelis (Common yellow scorpion)
Taxonomic identifieri539894 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeButhus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Peptidei23 – 5937Potassium channel toxin alpha-KTx 3.10PRO_0000368016Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 50By similarity
Disulfide bondi36 ↔ 55By similarity
Disulfide bondi40 ↔ 57By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamiPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSiPR00286. CHARYBDTOXIN.
ProDomiPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C908-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKVFFAVLIA LFVCSMVIGI HGGVPINVKC RGSRDCLDPC KKAGMRFGKC

INSKCHCTP
Length:59
Mass (Da):6,402
Last modified:April 14, 2009 - v1
Checksum:iFEE2327C83D2C862
GO

Mass spectrometryi

Molecular mass is 4015.6 Da from positions 23 - 59. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.30.10. 1 hit.
InterProi IPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view ]
Pfami PF00451. Toxin_2. 1 hit.
[Graphical view ]
PRINTSi PR00286. CHARYBDTOXIN.
ProDomi PD003586. Scorpion_toxinS. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF57095. SSF57095. 1 hit.
PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of the first toxin from the scorpion Buthus occitanus israelis showing preference for Shaker potassium channels."
    Kozminsky-Atias A., Somech E., Zilberberg N.
    FEBS Lett. 581:2478-2484(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-59, FUNCTION, MASS SPECTROMETRY.
    Tissue: Venom and Venom gland.

Entry informationi

Entry nameiKAX3A_BUTOS
AccessioniPrimary (citable) accession number: P0C908
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: October 29, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

Mammalian potassium channels (Kv2.1/KCNB1, Kir1.1/KCNJ1, Kv3.4/KCNC4, Kv4.2/KCND2, Kv7.1/KCNQ1, Kv7.2/KCNQ2, Kv7.3/KCNQ3 and Kv11.1/KCNH2) are even less affected by this toxin.1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3