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P0C908 (KAX3A_BUTOS) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 3.10
Alternative name(s):
BoiTx1
OrganismButhus occitanus israelis (Common yellow scorpion)
Taxonomic identifier539894 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeButhus

Protein attributes

Sequence length59 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits insect potassium channel. Is at least a hundred-fold more potent against the Drosophila Shaker channel than towards its mammalian homologs Kv1.1/KCNA1 and Kv1.3/KCNA3. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Miscellaneous

Mammalian potassium channels (Kv2.1/KCNB1, Kir1.1/KCNJ1, Kv3.4/KCNC4, Kv4.2/KCND2, Kv7.1/KCNQ1, Kv7.2/KCNQ2, Kv7.3/KCNQ3 and Kv11.1/KCNH2) are even less affected by this toxin (Ref.1).

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 3 subfamily.

Mass spectrometry

Molecular mass is 4015.6 Da from positions 23 - 59. Determined by MALDI. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.1
Peptide23 – 5937Potassium channel toxin alpha-KTx 3.10 Ref.1
PRO_0000368016

Amino acid modifications

Disulfide bond30 ↔ 50 By similarity
Disulfide bond36 ↔ 55 By similarity
Disulfide bond40 ↔ 57 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C908 [UniParc].

Last modified April 14, 2009. Version 1.
Checksum: FEE2327C83D2C862

FASTA596,402
        10         20         30         40         50 
MKVFFAVLIA LFVCSMVIGI HGGVPINVKC RGSRDCLDPC KKAGMRFGKC INSKCHCTP 

« Hide

References

[1]"Isolation of the first toxin from the scorpion Buthus occitanus israelis showing preference for Shaker potassium channels."
Kozminsky-Atias A., Somech E., Zilberberg N.
FEBS Lett. 581:2478-2484(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-59, FUNCTION, MASS SPECTROMETRY.
Tissue: Venom and Venom gland.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSPR00286. CHARYBDTOXIN.
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAX3A_BUTOS
AccessionPrimary (citable) accession number: P0C908
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: October 16, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries