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P0C8Z3

- UBP22_BOVIN

UniProt

P0C8Z3 - UBP22_BOVIN

Protein

Ubiquitin carboxyl-terminal hydrolase 22

Gene

USP22

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei174 – 1741NucleophilePROSITE-ProRule annotation
    Active sitei468 – 4681Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri50 – 11061UBP-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. H4 histone acetyltransferase activity Source: Ensembl
    2. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
    3. ubiquitin-specific protease activity Source: Ensembl
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. histone deubiquitination Source: Ensembl
    3. histone ubiquitination Source: Ensembl
    4. positive regulation of mitotic cell cycle Source: Ensembl
    5. positive regulation of transcription, DNA-templated Source: Ensembl
    6. transcription, DNA-templated Source: UniProtKB-KW
    7. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_219482. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 22 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 22
    Ubiquitin thioesterase 22
    Ubiquitin-specific-processing protease 22
    Gene namesi
    Name:USP22
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 19

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. SAGA complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Ubiquitin carboxyl-terminal hydrolase 22PRO_0000367510Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei118 – 1181N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000011818.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini165 – 509345USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. UBP8 subfamily.Curated
    Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri50 – 11061UBP-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5533.
    GeneTreeiENSGT00750000117288.
    HOGENOMiHOG000007260.
    HOVERGENiHBG058014.
    KOiK11366.
    OMAiYCQMCDD.
    OrthoDBiEOG7FR7G7.
    TreeFamiTF323554.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C8Z3-1 [UniParc]FASTAAdd to Basket

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    MDAELVVTPP GCAHLGSFKV DNWKQNLRAI YQCFVWSGSA EARKRKAKSC    50
    VCHVCGLHLN RLHSCLHCVF FGCFTKKHIH EHAKSKRHNL AIELMYGGIY 100
    CFLCQDYIYD KDIEIIAKEE QRKAWKMQGV GEKFSTWEPT KRELELLKHN 150
    PKRRKITSNC TIGLRGLINL GNTCFMNCIV QALTHTPLLR DFFLSDRHRC 200
    EMQSPSSCLV CEMSSLFQEF YSGHRSPHIP YKLLHLVWTH ARHLAGYEQQ 250
    DAHEFLIAAL DVLHRHCKGD DNGKKANNPN HCNCIIDQIF TGGLQSDVTC 300
    QVCHGVSTTI DPFWDISLDL PGSSTPFWPL SPGSESSVVN GESHVSGTTT 350
    LTDCLRRFTR PEHLGSSAKI KCSGCHSYQE STKQLTMKKL PIVACFHLKR 400
    FEHSAKLRRK ITTYVSFPLE LDMTPFMASS KESRMNGQYQ QPTDSLNNDN 450
    KYSLFAVVNH QGTLESGHYT SFIRQHKDQW FKCDDAIITK ASIADVLDSE 500
    GYLLFYHKQF LEYE 514
    Length:514
    Mass (Da):58,737
    Last modified:March 24, 2009 - v1
    Checksum:iD825824E36F6C7B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EE333442 mRNA. No translation available.
    EH202007 mRNA. No translation available.
    EV691513 mRNA. No translation available.
    RefSeqiNP_001160039.1. NM_001166567.1.
    UniGeneiBt.12486.

    Genome annotation databases

    EnsembliENSBTAT00000011818; ENSBTAP00000011818; ENSBTAG00000008978.
    GeneIDi509694.
    KEGGibta:509694.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EE333442 mRNA. No translation available.
    EH202007 mRNA. No translation available.
    EV691513 mRNA. No translation available.
    RefSeqi NP_001160039.1. NM_001166567.1.
    UniGenei Bt.12486.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000011818.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000011818 ; ENSBTAP00000011818 ; ENSBTAG00000008978 .
    GeneIDi 509694.
    KEGGi bta:509694.

    Organism-specific databases

    CTDi 23326.

    Phylogenomic databases

    eggNOGi COG5533.
    GeneTreei ENSGT00750000117288.
    HOGENOMi HOG000007260.
    HOVERGENi HBG058014.
    KOi K11366.
    OMAi YCQMCDD.
    OrthoDBi EOG7FR7G7.
    TreeFami TF323554.

    Enzyme and pathway databases

    Reactomei REACT_219482. HATs acetylate histones.

    Miscellaneous databases

    NextBioi 20869082.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Ascending colon, Brain cortex and Rumen.

    Entry informationi

    Entry nameiUBP22_BOVIN
    AccessioniPrimary (citable) accession number: P0C8Z3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3