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P0C8Z3 (UBP22_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 22

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 22
Ubiquitin thioesterase 22
Ubiquitin-specific-processing protease 22
Gene names
Name:USP22
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA complex By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the peptidase C19 family. UBP8 subfamily.

Contains 1 UBP-type zinc finger.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 514514Ubiquitin carboxyl-terminal hydrolase 22
PRO_0000367510

Regions

Domain165 – 509345USP
Zinc finger50 – 11061UBP-type

Sites

Active site1741Nucleophile By similarity
Active site4681Proton acceptor By similarity

Amino acid modifications

Modified residue1181N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C8Z3 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: D825824E36F6C7B4

FASTA51458,737
        10         20         30         40         50         60 
MDAELVVTPP GCAHLGSFKV DNWKQNLRAI YQCFVWSGSA EARKRKAKSC VCHVCGLHLN 

        70         80         90        100        110        120 
RLHSCLHCVF FGCFTKKHIH EHAKSKRHNL AIELMYGGIY CFLCQDYIYD KDIEIIAKEE 

       130        140        150        160        170        180 
QRKAWKMQGV GEKFSTWEPT KRELELLKHN PKRRKITSNC TIGLRGLINL GNTCFMNCIV 

       190        200        210        220        230        240 
QALTHTPLLR DFFLSDRHRC EMQSPSSCLV CEMSSLFQEF YSGHRSPHIP YKLLHLVWTH 

       250        260        270        280        290        300 
ARHLAGYEQQ DAHEFLIAAL DVLHRHCKGD DNGKKANNPN HCNCIIDQIF TGGLQSDVTC 

       310        320        330        340        350        360 
QVCHGVSTTI DPFWDISLDL PGSSTPFWPL SPGSESSVVN GESHVSGTTT LTDCLRRFTR 

       370        380        390        400        410        420 
PEHLGSSAKI KCSGCHSYQE STKQLTMKKL PIVACFHLKR FEHSAKLRRK ITTYVSFPLE 

       430        440        450        460        470        480 
LDMTPFMASS KESRMNGQYQ QPTDSLNNDN KYSLFAVVNH QGTLESGHYT SFIRQHKDQW 

       490        500        510 
FKCDDAIITK ASIADVLDSE GYLLFYHKQF LEYE 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Ascending colon, Brain cortex and Rumen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EE333442 mRNA. No translation available.
EH202007 mRNA. No translation available.
EV691513 mRNA. No translation available.
RefSeqNP_001160039.1. NM_001166567.1.
UniGeneBt.12486.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000011818.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000011818; ENSBTAP00000011818; ENSBTAG00000008978.
GeneID509694.
KEGGbta:509694.

Organism-specific databases

CTD23326.

Phylogenomic databases

eggNOGCOG5533.
GeneTreeENSGT00750000117288.
HOGENOMHOG000007260.
HOVERGENHBG058014.
KOK11366.
OMAYCQMCDD.
OrthoDBEOG7FR7G7.
TreeFamTF323554.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20869082.

Entry information

Entry nameUBP22_BOVIN
AccessionPrimary (citable) accession number: P0C8Z3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries