SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0C8Z3

- UBP22_BOVIN

UniProt

P0C8Z3 - UBP22_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ubiquitin carboxyl-terminal hydrolase 22

Gene
USP22
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei174 – 1741Nucleophile By similarity
Active sitei468 – 4681Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri50 – 11061UBP-typeAdd
BLAST

GO - Molecular functioni

  1. H4 histone acetyltransferase activity Source: Ensembl
  2. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
  3. ubiquitin-specific protease activity Source: Ensembl
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. histone deubiquitination Source: Ensembl
  3. histone ubiquitination Source: Ensembl
  4. positive regulation of mitotic cell cycle Source: Ensembl
  5. positive regulation of transcription, DNA-templated Source: Ensembl
  6. transcription, DNA-templated Source: UniProtKB-KW
  7. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_219482. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 22 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 22
Ubiquitin thioesterase 22
Ubiquitin-specific-processing protease 22
Gene namesi
Name:USP22
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. SAGA complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Ubiquitin carboxyl-terminal hydrolase 22PRO_0000367510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA complex By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011818.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 509345USPAdd
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5533.
GeneTreeiENSGT00750000117288.
HOGENOMiHOG000007260.
HOVERGENiHBG058014.
KOiK11366.
OMAiYCQMCDD.
OrthoDBiEOG7FR7G7.
TreeFamiTF323554.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C8Z3-1 [UniParc]FASTAAdd to Basket

« Hide

MDAELVVTPP GCAHLGSFKV DNWKQNLRAI YQCFVWSGSA EARKRKAKSC    50
VCHVCGLHLN RLHSCLHCVF FGCFTKKHIH EHAKSKRHNL AIELMYGGIY 100
CFLCQDYIYD KDIEIIAKEE QRKAWKMQGV GEKFSTWEPT KRELELLKHN 150
PKRRKITSNC TIGLRGLINL GNTCFMNCIV QALTHTPLLR DFFLSDRHRC 200
EMQSPSSCLV CEMSSLFQEF YSGHRSPHIP YKLLHLVWTH ARHLAGYEQQ 250
DAHEFLIAAL DVLHRHCKGD DNGKKANNPN HCNCIIDQIF TGGLQSDVTC 300
QVCHGVSTTI DPFWDISLDL PGSSTPFWPL SPGSESSVVN GESHVSGTTT 350
LTDCLRRFTR PEHLGSSAKI KCSGCHSYQE STKQLTMKKL PIVACFHLKR 400
FEHSAKLRRK ITTYVSFPLE LDMTPFMASS KESRMNGQYQ QPTDSLNNDN 450
KYSLFAVVNH QGTLESGHYT SFIRQHKDQW FKCDDAIITK ASIADVLDSE 500
GYLLFYHKQF LEYE 514
Length:514
Mass (Da):58,737
Last modified:March 24, 2009 - v1
Checksum:iD825824E36F6C7B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EE333442 mRNA. No translation available.
EH202007 mRNA. No translation available.
EV691513 mRNA. No translation available.
RefSeqiNP_001160039.1. NM_001166567.1.
UniGeneiBt.12486.

Genome annotation databases

EnsembliENSBTAT00000011818; ENSBTAP00000011818; ENSBTAG00000008978.
GeneIDi509694.
KEGGibta:509694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EE333442 mRNA. No translation available.
EH202007 mRNA. No translation available.
EV691513 mRNA. No translation available.
RefSeqi NP_001160039.1. NM_001166567.1.
UniGenei Bt.12486.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000011818.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000011818 ; ENSBTAP00000011818 ; ENSBTAG00000008978 .
GeneIDi 509694.
KEGGi bta:509694.

Organism-specific databases

CTDi 23326.

Phylogenomic databases

eggNOGi COG5533.
GeneTreei ENSGT00750000117288.
HOGENOMi HOG000007260.
HOVERGENi HBG058014.
KOi K11366.
OMAi YCQMCDD.
OrthoDBi EOG7FR7G7.
TreeFami TF323554.

Enzyme and pathway databases

Reactomei REACT_219482. HATs acetylate histones.

Miscellaneous databases

NextBioi 20869082.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon, Brain cortex and Rumen.

Entry informationi

Entry nameiUBP22_BOVIN
AccessioniPrimary (citable) accession number: P0C8Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi