P0C8Z2 (OMPA_ESCFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Outer membrane protein A

Alternative name(s):
Outer membrane protein II

Gene names

Name:

ompA

Organism

Escherichia fergusonii

Taxonomic identifier

564 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	243 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes By similarity.
Subunit structure	Monomer Probable.
Subcellular location	Cell outer membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the OmpA family. Contains 1 OmpA-like domain.

Ontologies

Keywords
Biological process	Conjugation Ion transport Transport
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Repeat Transmembrane Transmembrane beta strand
Molecular function	Porin
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	conjugation Inferred from electronic annotation. Source: UniProtKB-KW ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW pore complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	porin activity Inferred from electronic annotation. Source: UniProtKB-KW structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›243	›243	Outer membrane protein A		PRO_0000196254
Regions
	Transmembrane	‹1 – 8	›8	Beta stranded; Potential
	Transmembrane	12 – 27	16	Beta stranded; Potential
	Transmembrane	48 – 59	12	Beta stranded; Potential
	Transmembrane	65 – 81	17	Beta stranded; Potential
	Transmembrane	87 – 98	12	Beta stranded; Potential
	Repeat	107 – 108	2	1
	Repeat	109 – 110	2	2
	Repeat	111 – 112	2	3
	Repeat	113 – 114	2	4
	Domain	116 – ›243	›128	OmpA-like
	Region	107 – 114	8	4 X 2 AA tandem repeats of A-P
Amino acid modifications
	Disulfide bond	217 ↔ 229		By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	243	1

Sequences

	Sequence		Length	Mass (Da)
	P0C8Z2 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: B89F7FC29D42E3AB	FASTA	243	26,144
	10 20 30 40 50 60 LTAKLGYPIT DDLDIYTRLG GMVWRADTKA HNNVTGESEK NHDTGVSPVF AGGVEWAITP 70 80 90 100 110 120 EIATRLEYQW TNNIGDANTI GTRPDNGLLS LGVSYRFGQG EAAPVVAPAP APAPEVQTKH 130 140 150 160 170 180 FTLKSDVLFN FNKATLKPEG QAALDQLYSQ LSNLDPKDGS VVVLGYTDRI GSDAYNQGLS 190 200 210 220 230 240 ERRAQSVVDY LISKGIPADK ISARGMGESN PVTGNTCDNV KQRAALIDCL APDRRVEIEV KGI

References

[1]	"Molecular and evolutionary relationships among enteric bacteria." Lawrence J.G., Ochman H., Hartl D.L. J. Gen. Microbiol. 137:1911-1921(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 35471 / CDC 1016-74 and ATCC 35472 / CDC 3014-74.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M63352 Genomic DNA. Translation: AAA24236.1. M63353 Genomic DNA. Translation: AAA24240.1.
PIR	I62388.
3D structure databases
ProteinModelPortal	P0C8Z2.
SMR	P0C8Z2. Positions 1-103.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.40.160.20. 1 hit. 3.30.1330.60. 1 hit.
InterPro	IPR011250. OMP/PagP_b-brl. IPR006664. OMP_bac. IPR002368. OmpA. IPR006690. OMPA-like_CS. IPR000498. OmpA-like_TM_dom. IPR006665. OmpA/MotB_C. [Graphical view]
Pfam	PF00691. OmpA. 1 hit. PF01389. OmpA_membrane. 1 hit. [Graphical view]
PRINTS	PR01021. OMPADOMAIN. PR01022. OUTRMMBRANEA.
SUPFAM	SSF103088. OmpA/MotB_C. 1 hit. SSF56925. SSF56925. 1 hit.
PROSITE	PS01068. OMPA_1. 1 hit. PS51123. OMPA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OMPA_ESCFE

Accession

Primary (citable) accession number: P0C8Z2
Secondary accession number(s): P24747

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program