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Protein

Camelliol C synthase

Gene

CAMS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Converts oxidosqualene to camelliol C. Minor production of achilleol and beta-amyrin.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C.1 Publication

GO - Molecular functioni

  • beta-amyrin synthase activity Source: TAIR
  • camelliol C synthase activity Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciARA:AT1G78955-MONOMER.
MetaCyc:AT1G78955-MONOMER.
BRENDAi5.4.99.38. 399.

Names & Taxonomyi

Protein namesi
Recommended name:
Camelliol C synthase (EC:5.4.99.38)
Alternative name(s):
Lupeol synthase 3
Short name:
AtLUP3
Gene namesi
Name:CAMS1
Synonyms:LUP3
Ordered Locus Names:At1g78955
ORF Names:YUP8H12R.44
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G78955.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 769769Camelliol C synthasePRO_0000366133Add
BLAST

Proteomic databases

PaxDbiP0C8Y0.
PRIDEiP0C8Y0.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G78955.1.

Structurei

3D structure databases

ProteinModelPortaliP0C8Y0.
SMRiP0C8Y0. Positions 99-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati149 – 19042PFTB 1Add
BLAST
Repeati641 – 68242PFTB 2Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 2 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0497. Eukaryota.
COG1657. LUCA.
HOGENOMiHOG000234317.
InParanoidiP0C8Y0.
KOiK15822.
OMAiKSMHRHI.
PhylomeDBiP0C8Y0.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C8Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKLKIANGN KEEPYLFSTN NFLGRQTWEF DPDAGTVEEL AAVEEARRKF
60 70 80 90 100
YDDRFRVKAS SDLIWRMQFL KEKKFEQVIP PAKVEDANNI TSEIATNALR
110 120 130 140 150
KGVNFLSALQ ASDGHWPAEN AGPLFFLPPL VFCLYVTGHL HEIFTQDHRR
160 170 180 190 200
EVLRYIYCHQ NEDGGWGLHI EGNSTMFCTT LNYICMRILG EGPNGGPGNA
210 220 230 240 250
CKRARDWILD HGGATYIPSW GKTWLSILGV FDWSGSNPMP PEFWILPSFL
260 270 280 290 300
PIHPAKMWCY CRLVYMPMSY LYGKRFVGPI SPLILQLREE IYLQPYAKIN
310 320 330 340 350
WNRARHLCAK EDAYCPHPQI QDVIWNCLYI FTEPFLACWP FNKLLREKAL
360 370 380 390 400
GVAMKHIHYE DENSRYITIG CVEKALCMLA CWVEDPNGIH FKKHLLRISD
410 420 430 440 450
YLWIAEDGMK MQSFGSQLWD SGFALQALVA SNLVNEIPDV LRRGYDFLKN
460 470 480 490 500
SQVRENPSGD FTNMYRHISK GSWTFSDRDH GWQASDCTAE SFKCCLLLSM
510 520 530 540 550
IPPDIVGPKM DPEQLYEAVT ILLSLQSKNG GVTAWEPARG QEWLELLNPT
560 570 580 590 600
EVFADIVVEH EYNECTSSAI QALILFKQLY PNHRTEEINT SIKKAVQYIE
610 620 630 640 650
SIQMLDGSWY GSWGVCFTYS TWFGLGGLAA AGKTYNNCLA MRKGVHFLLT
660 670 680 690 700
TQKDNGGWGE SYLSCPKKRY IPSEGERSNL VQTSWAMMGL LHAGQAERDP
710 720 730 740 750
SPLHRAAKLL INSQLENGDF PQQEITGAFM KNCLLHYAAY RNIFPVWALA
760
EYRRRVPLPY EKPSTERRS
Length:769
Mass (Da):88,156
Last modified:March 3, 2009 - v1
Checksum:i30B7372DD5703C60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002986 Genomic DNA. Translation: AAC17080.1.
CP002684 Genomic DNA. Translation: AEE36184.1.
PIRiT01060.
RefSeqiNP_683508.1. NM_148667.1.
UniGeneiAt.52564.

Genome annotation databases

EnsemblPlantsiAT1G78955.1; AT1G78955.1; AT1G78955.
GeneIDi844235.
GrameneiAT1G78955.1; AT1G78955.1; AT1G78955.
KEGGiath:AT1G78955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002986 Genomic DNA. Translation: AAC17080.1.
CP002684 Genomic DNA. Translation: AEE36184.1.
PIRiT01060.
RefSeqiNP_683508.1. NM_148667.1.
UniGeneiAt.52564.

3D structure databases

ProteinModelPortaliP0C8Y0.
SMRiP0C8Y0. Positions 99-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G78955.1.

Proteomic databases

PaxDbiP0C8Y0.
PRIDEiP0C8Y0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G78955.1; AT1G78955.1; AT1G78955.
GeneIDi844235.
GrameneiAT1G78955.1; AT1G78955.1; AT1G78955.
KEGGiath:AT1G78955.

Organism-specific databases

TAIRiAT1G78955.

Phylogenomic databases

eggNOGiKOG0497. Eukaryota.
COG1657. LUCA.
HOGENOMiHOG000234317.
InParanoidiP0C8Y0.
KOiK15822.
OMAiKSMHRHI.
PhylomeDBiP0C8Y0.

Enzyme and pathway databases

BioCyciARA:AT1G78955-MONOMER.
MetaCyc:AT1G78955-MONOMER.
BRENDAi5.4.99.38. 399.

Miscellaneous databases

PROiP0C8Y0.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana."
    Husselstein-Muller T., Schaller H., Benveniste P.
    Plant Mol. Biol. 45:75-92(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE.
  4. "Arabidopsis camelliol C synthase evolved from enzymes that make pentacycles."
    Kolesnikova M.D., Wilson W.K., Lynch D.A., Obermeyer A.C., Matsuda S.P.T.
    Org. Lett. 9:5223-5226(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiLUP3_ARATH
AccessioniPrimary (citable) accession number: P0C8Y0
Secondary accession number(s): O64553
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 17, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.