P0C8X3 (HYAL_TITST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Hyaluronidase EC=3.2.1.35 Alternative name(s): Cysteine-rich venom protein Short name=CRVP Hyaluronoglucosaminidase A
Organism	Tityus stigmurus (Brazilian scorpion)
Taxonomic identifier	50344 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Tityus

Protein attributes

Sequence length	24 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Possesses high activity against hyaluronan in vitro. Ref.1
Catalytic activity	Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the CRISP family.
Mass spectrometry	Molecular mass is 44800.0 Da from positions 1 - ?. Determined by ESI. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Hydrolase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	hyalurononglucosaminidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – ›24	›24	Hyaluronidase		PRO_0000366111
Experimental info
	Non-terminal residue	24	1

Sequences

	Sequence		Length	Mass (Da)
	P0C8X3 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: EEC76D5D0426A345	FASTA	24	2,966
	10 20 EHPALYRRYS KEHTFCKTKN QXCN

References

[1]

"Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species." Batista C.V.F., Roman-Gonzalez S.A., Salas-Castillo S.P., Zamudio F.Z., Gomez-Lagunas F., Possani L.D. Comp. Biochem. Physiol. 146C:147-157(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY. Tissue: Venom.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
PROSITE	PS01009. CRISP_1. Partial match. PS01010. CRISP_2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HYAL_TITST

Accession

Primary (citable) accession number: P0C8X3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)