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Protein

Hyaluronidase

Gene
N/A
Organism
Tityus stigmurus (Brazilian scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possesses high activity against hyaluronan in vitro.1 Publication

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase (EC:3.2.1.35)
Alternative name(s):
Cysteine-rich venom protein
Short name:
CRVP
Hyaluronoglucosaminidase A
OrganismiTityus stigmurus (Brazilian scorpion)
Taxonomic identifieri50344 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003661111 – ›24HyaluronidaseAdd BLAST›24

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Belongs to the CRISP family.Curated

Sequencei

Sequence statusi: Fragment.

P0C8X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
EHPALYRRYS KEHTFCKTKN QXCN
Length:24
Mass (Da):2,966
Last modified:March 3, 2009 - v1
Checksum:iEEC76D5D0426A345
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei241

Mass spectrometryi

Molecular mass is 44800.0 Da from positions 1 - ?. Determined by ESI. 1 Publication

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHYAL_TITST
AccessioniPrimary (citable) accession number: P0C8X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: January 7, 2015
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families