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P0C8W4

- KBX2_TITST

UniProt

P0C8W4 - KBX2_TITST

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Protein
Potassium channel toxin TstKMK
Gene
N/A
Organism
Tityus stigmurus (Brazilian scorpion)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Blocks voltage-gated potassium channels (Kv) By similarity.

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin TstKMK
Alternative name(s):
Toxin 5536
beta-Ktx
OrganismiTityus stigmurus (Brazilian scorpion)
Taxonomic identifieri50344 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Propeptidei26 – 4217
PRO_0000421251Add
BLAST
Chaini43 – 9149Potassium channel toxin TstKMK
PRO_0000366102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi61 ↔ 81 By similarity
Disulfide bondi68 ↔ 86 By similarity
Disulfide bondi72 ↔ 88 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C8W4-1 [UniParc]FASTAAdd to Basket

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MVATNRCCVF ALLFALLLVH SLTEAGKGKE ILGKIKEKII EAKDKMKAGW   50
ERLTSQSEYA CPAIDKFCED HCAAKKAVGK CDDFKCKCIK L 91
Length:91
Mass (Da):10,097
Last modified:February 6, 2013 - v2
Checksum:i39EED225DDFC4589
GO

Mass spectrometryi

Molecular mass is 5536.0 Da from positions 43 - 91. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JK483711 mRNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JK483711 mRNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR029237. Long_scorpion_toxin.
[Graphical view ]
Pfami PF14866. Toxin_38. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular approaches for structural characterization of a new potassium channel blocker from Tityus stigmurus venom: cDNA cloning, homology modeling, dynamic simulations and docking."
    Almeida D.D., Torres T.M., Barbosa E.G., Lima J.P., de Freitas Fernandes-Pedrosa M.
    Biochem. Biophys. Res. Commun. 430:113-118(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], 3D-STRUCTURE MODELING.
    Tissue: Venom gland.
  2. "Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species."
    Batista C.V.F., Roman-Gonzalez S.A., Salas-Castillo S.P., Zamudio F.Z., Gomez-Lagunas F., Possani L.D.
    Comp. Biochem. Physiol. 146C:147-157(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 43-57, MASS SPECTROMETRY.
    Tissue: Venom.

Entry informationi

Entry nameiKBX2_TITST
AccessioniPrimary (citable) accession number: P0C8W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2013
Last modified: July 9, 2014
This is version 14 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

A mature protein with 47 amino acid residues is predicted in 1 Publication (sequence of 45-91) instead of the chain proposed here (2 amino acids longer). Since the protein sequence and the predicted mass correspond exactly with proteomic data (1 Publication), the 49 amino acid chain is shown.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi