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P0C8W4

- KBX2_TITST

UniProt

P0C8W4 - KBX2_TITST

Protein

Potassium channel toxin TstKMK

Gene
N/A
Organism
Tityus stigmurus (Brazilian scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Blocks voltage-gated potassium channels (Kv).By similarity

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin TstKMK
    Alternative name(s):
    Toxin 5536
    beta-Ktx
    OrganismiTityus stigmurus (Brazilian scorpion)
    Taxonomic identifieri50344 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 42171 PublicationPRO_0000421251Add
    BLAST
    Chaini43 – 9149Potassium channel toxin TstKMKPRO_0000366102Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi61 ↔ 81By similarity
    Disulfide bondi68 ↔ 86By similarity
    Disulfide bondi72 ↔ 88By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR029237. Long_scorpion_toxin.
    [Graphical view]
    PfamiPF14866. Toxin_38. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C8W4-1 [UniParc]FASTAAdd to Basket

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    MVATNRCCVF ALLFALLLVH SLTEAGKGKE ILGKIKEKII EAKDKMKAGW   50
    ERLTSQSEYA CPAIDKFCED HCAAKKAVGK CDDFKCKCIK L 91
    Length:91
    Mass (Da):10,097
    Last modified:February 6, 2013 - v2
    Checksum:i39EED225DDFC4589
    GO

    Mass spectrometryi

    Molecular mass is 5536.0 Da from positions 43 - 91. Determined by ESI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JK483711 mRNA. No translation available.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JK483711 mRNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR029237. Long_scorpion_toxin.
    [Graphical view ]
    Pfami PF14866. Toxin_38. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular approaches for structural characterization of a new potassium channel blocker from Tityus stigmurus venom: cDNA cloning, homology modeling, dynamic simulations and docking."
      Almeida D.D., Torres T.M., Barbosa E.G., Lima J.P., de Freitas Fernandes-Pedrosa M.
      Biochem. Biophys. Res. Commun. 430:113-118(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], 3D-STRUCTURE MODELING.
      Tissue: Venom gland.
    2. "Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species."
      Batista C.V.F., Roman-Gonzalez S.A., Salas-Castillo S.P., Zamudio F.Z., Gomez-Lagunas F., Possani L.D.
      Comp. Biochem. Physiol. 146C:147-157(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 43-57, MASS SPECTROMETRY.
      Tissue: Venom.

    Entry informationi

    Entry nameiKBX2_TITST
    AccessioniPrimary (citable) accession number: P0C8W4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: February 6, 2013
    Last modified: October 1, 2014
    This is version 15 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Caution

    A mature protein with 47 amino acid residues is predicted in PubMed:17270501 (sequence of 45-91) instead of the chain proposed here (2 amino acids longer). Since the protein sequence and the predicted mass correspond exactly with proteomic data (PubMed:17270501), the 49 amino acid chain is shown.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3