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Protein

Alpha-conotoxin CnIC

Gene
N/A
Organism
Conus consors (Singed cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity

Miscellaneous

Found in injectable (milked) (IV) venom.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin CnIC
Cleaved into the following 2 chains:
Alternative name(s):
Alpha-conotoxin-like Cn1.1
[Asp1]-CnIH
OrganismiConus consors (Singed cone)
Taxonomic identifieri101297 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri3711. CnIH precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000036605422 – 47Add BLAST26
PeptideiPRO_000036605548 – 62Alpha-conotoxin CnIHAdd BLAST15
PeptideiPRO_000041982649 – 62Alpha-conotoxin CnIFAdd BLAST14
PeptideiPRO_000041982751 – 62Alpha-conotoxin CnICAdd BLAST12

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48Deamidated asparagine; in CnIH; partial1 Publication1
Disulfide bondi51 ↔ 56By similarity
Disulfide bondi52 ↔ 62By similarity
Modified residuei62Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha3/5 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
IPR018072. Conotoxin_a-typ_CS.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.
PROSITEiView protein in PROSITE
PS60014. ALPHA_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C8U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMMFTVF LLVVLTTTVV SFPSDSASDV RDDEAKDERS DMYKSKRNGR
60
CCHPACGKHF SCGR
Length:64
Mass (Da):7,209
Last modified:October 31, 2012 - v2
Checksum:i6EF718D09A422F7F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10F → G no nucleotide entry (PubMed:16905531).Curated1

Mass spectrometryi

Molecular mass is 1286.48 Da from positions 51 - 62. Determined by ESI. CnIC.1 Publication
Molecular mass is 1499.58 Da from positions 49 - 62. Determined by ESI. CnIF.1 Publication
Molecular mass is 1613.64 Da from positions 48 - 62. Determined by ESI. CnIH.1 Publication
Molecular mass is 1614.63 Da from positions 48 - 62. Determined by ESI. Deamidated CnIH.1 Publication

Similar proteinsi

Entry informationi

Entry nameiCA1C_CONCN
AccessioniPrimary (citable) accession number: P0C8U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 31, 2012
Last modified: November 22, 2017
This is version 25 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families