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Protein

Alpha-conotoxin PrXA

Gene
N/A
Organism
Conus parius (Cone snail)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibit both adult and fetal (alpha-1/beta-1/epsilon/delta and alpha-1/beta-1/gamma/delta subunits) mammalian muscle nicotinic acetylcholine receptors (nAChR). Causes paralysis and death in mice and fish.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin PrXA
Short name:
Alpha-C-PrXA
OrganismiConus parius (Cone snail)
Taxonomic identifieri505247 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri2859. PrXA.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003660321 – 32Alpha-conotoxin PrXAAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104-hydroxyproline1 Publication1
Disulfide bondi13 ↔ 201 Publication
Modified residuei244-hydroxyproline1 Publication1
Modified residuei284-hydroxyproline1 Publication1
Modified residuei32Glutamic acid 1-amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0C8S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is C-C.

Sequencei

Sequence statusi: Complete.

P0C8S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
TYGIYDAKPP FSCAGLRGGC VLPPNLRPKF KE
Length:32
Mass (Da):3,496
Last modified:March 3, 2009 - v1
Checksum:i6343F3978F56C62B
GO

Mass spectrometryi

Molecular mass is 3540.7 Da from positions 1 - 32. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiCCAA_CONPI
AccessioniPrimary (citable) accession number: P0C8S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 22, 2017
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing