P0C8S3 (RL7_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L7/L12

Gene names

Name:	rplL
Ordered Locus Names:	CBU_0229

Organism

Coxiella burnetii

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	126 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation By similarity. HAMAP MF_00368
Developmental stage	Detected in both the small cell variant (SCV) and in the large cell variant (LCV) stage (at protein level). LCVs are more metabolically active than SCVs. Ref.2
Sequence similarities	Belongs to the ribosomal protein L12P family.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 126	126	50S ribosomal protein L7/L12 HAMAP MF_00368		PRO_0000157525

Sequences

	Sequence		Length	Mass (Da)
	P0C8S3 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 9D39AC0B10A599D3	FASTA	126	13,248
	10 20 30 40 50 60 MAQLSKDDIL EAVANMSVMD VVDLVKAMEE KFGVSAQAAI AVAGPVAGGE AAAAEEKTEF 70 80 90 100 110 120 NVKMVSFGDN KIGVIKAIRT ITGLGLKEAK DLVESVPSVV KESVSKEEAE KIKKELEEAG AKVELE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.
[2]	"Proteome and antigen profiling of Coxiella burnetii developmental forms." Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J., Samuel J.E., Heinzen R.A. Infect. Immun. 75:290-298(2007) [PubMed: 17088354] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DEVELOPMENTAL STAGE. Strain: Nine Mile Crazy / RSA 514.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO89787.1.
RefSeq	NP_819273.1. NC_002971.3.
3D structure databases
ProteinModelPortal	P0C8S3.
SMR	P0C8S3. Positions 4-126.
ModBase	Search...
Proteomic databases
PRIDE	P0C8S3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1208110.
GenomeReviews	Gene locus CBU_0229 in contig AE016828_GR.
KEGG	cbu:CBU_0229.
PATRIC	17929149. VBICoxBur82552_0223.
TIGR	CBU_0229.
Phylogenomic databases
HOGENOM	HBG746222.
OMA	EAVKNMT.
PhylomeDB	P0C8S3.
ProtClustDB	PRK00157.
Family and domain databases
HAMAP	MF_00368. Ribosomal_L7_L12. [Tree]
InterPro	IPR000206. Ribosomal_L7/12. IPR014719. Ribosomal_L7/12_C/ClpS-like. IPR013823. Ribosomal_L7/L12_C. IPR008932. Ribosomal_L7/L12_oligo. [Graphical view]
Gene3D	G3DSA:3.30.1390.10. Ribosomal_L7/12_C/ClpS-like. 1 hit.
KO	K02935.
Pfam	PF00542. Ribosomal_L12. 1 hit. [Graphical view]
ProDom	PD001326. Ribosomal_L7/L12_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF48300. Ribosomal_L12/7. 1 hit. SSF54736. Ribosomal_L7/12_C/ClpS-like. 1 hit.
TIGRFAMs	TIGR00855. L12. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RL7_COXBU

Accession

Primary (citable) accession number: P0C8S3
Secondary accession number(s): O87902

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program