Reviewed, UniProtKB/Swiss-Prot P0C8R5 (AAXB_CHLTB)

Names and origin

Protein names

Recommended name:
    Pyruvoyl-dependent arginine decarboxylase aaxB
      Short name=PvlArgDC
    EC=4.1.1.19
Alternative name(s):
    Biodegradative arginine decarboxylase
Cleaved into the following 2 chains:
    1- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase subunit beta
    2- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase subunit alpha

Gene names

Name:	aaxB
Ordered Locus Names:	CTLon_0625

Organism

Chlamydia trachomatis (strain L2b/UCH-1/proctitis) [Complete proteome] [HAMAP]

Taxonomic identifier

471473 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of the aaxABC system, catalyzes the decarboxylation of L-arginine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response By similarity.
Catalytic activity	L-arginine = agmatine + CO2.
Cofactor	Pyruvoyl group By similarity.
Subunit structure	Trimer of an alpha-beta dimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyruvoyl-dependent arginine decarboxylase family.
Sequence caution	The sequence AM884177 differs from that shown. Reason: Erroneous termination at position 128. Translated as Trp.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 52	52	Pyruvoyl-dependent arginine decarboxylase subunit beta		PRO_0000364037
	Chain	53 – 195	143	Pyruvoyl-dependent arginine decarboxylase subunit alpha		PRO_0000364038
Sites
	Site	52 – 53	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	53	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C8R5-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 29C4CF9A309EC05A	FASTA	195	21,751
	10 20 30 40 50 60 MPYGTRYPTL AFHTGGVGES DDGMPPQPFE TFCYDSALLQ AKIENFNIVP YTSVLPKELF 70 80 90 100 110 120 GNILPVDQCT KFFKHGAVLE VIMAGRGATV TDGTQAIATG VGICWGKDKN GELIGGWAAE 130 140 150 160 170 180 YVEFFPTWID DEIAESHAKM WLKKSLQHEL DLRSVSKHSE FQYFHNYINI RKKFGFCLTA 190 LGFLNFENAA PAVIQ

References

[1]

"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates." Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. Genome Res. 18:161-171(2008) [PubMed: 18032721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM884177 Genomic DNA. No translation available.
3D structure databases
ModBase	Search...
Genome annotation databases
GenomeReviews	Gene locus CTLon_0625 in contig AM884177_GR.
KEGG	ctl:CTLon_0625.
Organism-specific databases
CMR	Search...
Family and domain databases
InterPro	IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAXB_CHLTB

Accession

Primary (citable) accession number: P0C8R5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	June 16, 2009
This is version 5 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)