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P0C8R4

- AAXB_CHLT2

UniProt

P0C8R4 - AAXB_CHLT2

Protein

Pyruvoyl-dependent arginine decarboxylase AaxB

Gene

aaxB

Organism
Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Part of the AaxABC system, catalyzes the decarboxylation of L-arginine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response By similarity.By similarity

    Catalytic activityi

    L-arginine = agmatine + CO2.

    Cofactori

    Pyruvoyl group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei52 – 532Cleavage (non-hydrolytic)By similarity

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Virulence

    Keywords - Ligandi

    Pyruvate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvoyl-dependent arginine decarboxylase AaxB (EC:4.1.1.19)
    Short name:
    PvlArgDC
    Alternative name(s):
    Biodegradative arginine decarboxylase
    Cleaved into the following 2 chains:
    Gene namesi
    Name:aaxB
    Ordered Locus Names:CTL0627
    OrganismiChlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
    Taxonomic identifieri471472 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000795: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5252Pyruvoyl-dependent arginine decarboxylase subunit betaPRO_0000364035Add
    BLAST
    Chaini53 – 195143Pyruvoyl-dependent arginine decarboxylase subunit alphaPRO_0000364036Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei53 – 531Pyruvic acid (Ser)By similarity

    Interactioni

    Subunit structurei

    Trimer of an alpha-beta dimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0C8R4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.50.20.10. 1 hit.
    InterProiIPR016104. Pyr-dep_his/arg-deCO2ase.
    IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
    IPR002724. Pyruvoyl-dep_arg_deCO2ase.
    [Graphical view]
    PfamiPF01862. PvlArgDC. 1 hit.
    [Graphical view]
    ProDomiPD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56271. SSF56271. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C8R4-1 [UniParc]FASTAAdd to Basket

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    MPYGTRYPTL AFHTGGVGES DDGMPPQPFE TFCYDSALLQ AKIENFNIVP    50
    YTSVLPKELF GNILPVDQCT KFFKHGAVLE VIMAGRGATV TDGTQAIATG 100
    VGICWGKDKN GELIGGWAAE YVEFFPTWID DEIAESHAKM WLKKSLQHEL 150
    DLRSVSKHSE FQYFHNYINI RKKFGFCLTA LGFLNFENAA PAVIQ 195
    Length:195
    Mass (Da):21,751
    Last modified:February 10, 2009 - v1
    Checksum:i29C4CF9A309EC05A
    GO

    Sequence cautioni

    The sequence AM884176 differs from that shown. Reason: Erroneous termination at position 128. Translated as Trp.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM884176 Genomic DNA. No translation available.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM884176 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali P0C8R4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.50.20.10. 1 hit.
    InterProi IPR016104. Pyr-dep_his/arg-deCO2ase.
    IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
    IPR002724. Pyruvoyl-dep_arg_deCO2ase.
    [Graphical view ]
    Pfami PF01862. PvlArgDC. 1 hit.
    [Graphical view ]
    ProDomi PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56271. SSF56271. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 434/Bu / ATCC VR-902B.

    Entry informationi

    Entry nameiAAXB_CHLT2
    AccessioniPrimary (citable) accession number: P0C8R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3