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Protein

Lectin-like protein BA14k

Gene

BruAb2_0497

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has immunoglobulin-binding and hemagglutination properties, and can bind to mannose. Essential for virulence. May be involved in LPS biosynthesis or polysaccharide transport (By similarity).By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2709-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lectin-like protein BA14k
Gene namesi
Ordered Locus Names:BruAb2_0497
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540 Componenti: Chromosome II

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei80 – 10021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 147121Lectin-like protein BA14kPRO_0000361297Add
BLAST

Proteomic databases

PRIDEiP0C8N0.

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb2_0497.

Family & Domainsi

Sequence similaritiesi

Belongs to the BA14k family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG08130.
HOGENOMiHOG000274446.
OMAiHVAWCAN.
OrthoDBiEOG6358FW.

Family and domain databases

InterProiIPR012413. BA14K.
[Graphical view]
PfamiPF07886. BA14K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C8N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSFRKTCAG ALALIFGATS IVPTVAAPMN MDRPAINQNV IQARAHYRPQ
60 70 80 90 100
NYNRGHRPGY WHGHRGYRHY RHGYRRHNDG WWYPLAAFGA GAIIGGAISQ
110 120 130 140
PRPVYRAPAG SPHVQWCYSR YKSYRASDNT FQPYNGPRKQ CRSPYSR
Length:147
Mass (Da):16,823
Last modified:January 20, 2009 - v1
Checksum:i7CEE6F1FB2BB38DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017224 Genomic DNA. Translation: AAX75916.1.
PIRiAG3578.
RefSeqiYP_223277.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX75916; AAX75916; BruAb2_0497.
KEGGibmb:BruAb2_0497.
PATRICi17827256. VBIBruAbo15061_2806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017224 Genomic DNA. Translation: AAX75916.1.
PIRiAG3578.
RefSeqiYP_223277.1. NC_006933.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262698.BruAb2_0497.

Proteomic databases

PRIDEiP0C8N0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX75916; AAX75916; BruAb2_0497.
KEGGibmb:BruAb2_0497.
PATRICi17827256. VBIBruAbo15061_2806.

Phylogenomic databases

eggNOGiNOG08130.
HOGENOMiHOG000274446.
OMAiHVAWCAN.
OrthoDBiEOG6358FW.

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2709-MONOMER.

Family and domain databases

InterProiIPR012413. BA14K.
[Graphical view]
PfamiPF07886. BA14K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry namei14KL_BRUAB
AccessioniPrimary (citable) accession number: P0C8N0
Secondary accession number(s): Q44701, Q578L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 20, 2009
Last modified: April 1, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.