P0C8L6 (PHS_HYPDU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable pterin-4-alpha-carbinolamine dehydratase
Short name=PHS
EC=4.2.1.96

Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase
Pterin carbinolamine dehydratase
Short name=PCD

Gene names

Name:

Pcd

Organism

Hypsibius dujardini (Water bear) (Macrobiotus dujardini)

Taxonomic identifier

232323 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Tardigrada › Eutardigrada › Parachela › Hypsibiidae › Hypsibius

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in tetrahydrobiopterin biosynthesis By similarity.
Catalytic activity	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.
Sequence similarities	Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

Ontologies

Keywords
Biological process	Tetrahydrobiopterin biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	Probable pterin-4-alpha-carbinolamine dehydratase		PRO_0000357456

Sequences

	Sequence		Length	Mass (Da)
	P0C8L6 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: EB5ECBADB3987B8C	FASTA	103	11,706
	10 20 30 40 50 60 MDPRLTHEDR ILHLAPLTEK GWLLVEGRDA IHKEFKFKDF NAAFGFMTRV ALLAEKMDHH 70 80 90 100 PEWFNVYNKV QITLSSHDVA GLSQRDIKLA SFIEKAAVGA STS

References

[1]	"A survey of genes expressed in the tardigrade Hypsibius dujardini." Daub J., Thomas F., Aboobaker A., Blaxter M.L. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Sciento Z151.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CK326948 mRNA. No translation available.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001533. Trans/pterin_deHydtase. [Graphical view]
Gene3D	G3DSA:3.30.1360.20. Trans_pterinDh. 1 hit.
PANTHER	PTHR12599. Trans_pterinDh. 1 hit.
Pfam	PF01329. Pterin_4a. 1 hit. [Graphical view]
SUPFAM	SSF55248. Trans_pterinDh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PHS_HYPDU

Accession

Primary (citable) accession number: P0C8L6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	December 16, 2008
Last modified:	January 11, 2011
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)