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P0C8K9

- COX1_CANAL

UniProt

P0C8K9 - COX1_CANAL

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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme A axial ligand)By similarity
Metal bindingi243 – 2431Copper BBy similarity
Metal bindingi247 – 2471Copper BBy similarity
Metal bindingi292 – 2921Copper BBy similarity
Metal bindingi293 – 2931Copper BBy similarity
Metal bindingi378 – 3781Iron (heme A3 axial ligand)By similarity
Metal bindingi380 – 3801Iron (heme A axial ligand)By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: CGD
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. mitochondrial electron transport, cytochrome c to oxygen Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
ORF Names:CaalfMp08
Encoded oniMitochondrion
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Mitochondrion

Organism-specific databases

CGDiCAF0007377. COX1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence AnalysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence AnalysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence AnalysisAdd
BLAST
Transmembranei414 – 43421HelicalSequence AnalysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Cytochrome c oxidase subunit 1PRO_0000356866Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Protein-protein interaction databases

STRINGi5476.CAF0007377.

Structurei

3D structure databases

ProteinModelPortaliP0C8K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
InParanoidiP0C8K9.
OrthoDBiEOG72C58S.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C8K9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYVTRWLFS TSHKDIGILY LIYGMVSAMV ATGMSVIIRL ELSGPGPMFL
60 70 80 90 100
HGNNQVFNVL VTGHAIAMIF LFVMPILIGS FGNYFLPIMI GAVDMAFARL
110 120 130 140 150
NNISFWCLPP ALVCVIASVL IETGAGTGWT VYPPLSSISA HSGPSVDLAI
160 170 180 190 200
FAIHLTSISS LLGAINFIVT TLNMRSIGIH MIDMPLFVWA IFFTAILLLL
210 220 230 240 250
SLPVLTAGVT LLLMDRNFNT GFYEVAAGGD PILYEHLFYF FGHPEVYIII
260 270 280 290 300
IPGFGIISHV ISTYTKKPIF GQIGMIYAIG SIGLLGFLVW SHHMYVVGLD
310 320 330 340 350
IDSRAYFTSA TMVIAIPTGI KIFSWLATLY GGELRLAVPM LFALGFLFLF
360 370 380 390 400
TIGGLTGVML SNASIDVAFH DTYYVVGHFH YVLSMGALFS LIAGYYYWGP
410 420 430 440 450
AMFGLKYNKV LAEVHYWLLF VSVNIIFLPM HFLGLNGMPR RIPQYPDAFV
460 470 480 490 500
GWNVVSSWGS IMSVISVLIG LYSVLVQLTN GENEREEIQV TPDYLESNNT
510 520 530
RDVRDSDLEL ITSRPAQYHT FSELPILIQQ I
Length:531
Mass (Da):58,744
Last modified:December 16, 2008 - v1
Checksum:iEDB63911A328C6AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285261 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285261 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali P0C8K9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAF0007377.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

CGDi CAF0007377. COX1.

Phylogenomic databases

eggNOGi COG0843.
InParanoidi P0C8K9.
OrthoDBi EOG72C58S.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans."
    Anderson J.B., Wickens C., Khan M., Cowen L.E., Federspiel N.A., Jones T., Kohn L.M.
    J. Bacteriol. 183:865-872(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCOX1_CANAL
AccessioniPrimary (citable) accession number: P0C8K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3