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P0C8K9

- COX1_CANAL

UniProt

P0C8K9 - COX1_CANAL

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Protein

Cytochrome c oxidase subunit 1

Gene
COX1, CaalfMp08
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme A axial ligand) By similarity
Metal bindingi243 – 2431Copper B By similarity
Metal bindingi247 – 2471Copper B By similarity
Metal bindingi292 – 2921Copper B By similarity
Metal bindingi293 – 2931Copper B By similarity
Metal bindingi378 – 3781Iron (heme A3 axial ligand) By similarity
Metal bindingi380 – 3801Iron (heme A axial ligand) By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: CGD
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. mitochondrial electron transport, cytochrome c to oxygen Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
ORF Names:CaalfMp08
Encoded oniMitochondrion
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Mitochondrion

Organism-specific databases

CGDiCAF0007377. COX1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821Helical; Reviewed predictionAdd
BLAST
Transmembranei59 – 7921Helical; Reviewed predictionAdd
BLAST
Transmembranei103 – 12321Helical; Reviewed predictionAdd
BLAST
Transmembranei149 – 16921Helical; Reviewed predictionAdd
BLAST
Transmembranei185 – 20521Helical; Reviewed predictionAdd
BLAST
Transmembranei237 – 25721Helical; Reviewed predictionAdd
BLAST
Transmembranei269 – 28921Helical; Reviewed predictionAdd
BLAST
Transmembranei312 – 33221Helical; Reviewed predictionAdd
BLAST
Transmembranei340 – 36021Helical; Reviewed predictionAdd
BLAST
Transmembranei385 – 40521Helical; Reviewed predictionAdd
BLAST
Transmembranei414 – 43421Helical; Reviewed predictionAdd
BLAST
Transmembranei458 – 47821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Cytochrome c oxidase subunit 1PRO_0000356866Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Protein-protein interaction databases

STRINGi5476.CAF0007377.

Structurei

3D structure databases

ProteinModelPortaliP0C8K9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
OrthoDBiEOG72C58S.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C8K9-1 [UniParc]FASTAAdd to Basket

« Hide

MSYVTRWLFS TSHKDIGILY LIYGMVSAMV ATGMSVIIRL ELSGPGPMFL    50
HGNNQVFNVL VTGHAIAMIF LFVMPILIGS FGNYFLPIMI GAVDMAFARL 100
NNISFWCLPP ALVCVIASVL IETGAGTGWT VYPPLSSISA HSGPSVDLAI 150
FAIHLTSISS LLGAINFIVT TLNMRSIGIH MIDMPLFVWA IFFTAILLLL 200
SLPVLTAGVT LLLMDRNFNT GFYEVAAGGD PILYEHLFYF FGHPEVYIII 250
IPGFGIISHV ISTYTKKPIF GQIGMIYAIG SIGLLGFLVW SHHMYVVGLD 300
IDSRAYFTSA TMVIAIPTGI KIFSWLATLY GGELRLAVPM LFALGFLFLF 350
TIGGLTGVML SNASIDVAFH DTYYVVGHFH YVLSMGALFS LIAGYYYWGP 400
AMFGLKYNKV LAEVHYWLLF VSVNIIFLPM HFLGLNGMPR RIPQYPDAFV 450
GWNVVSSWGS IMSVISVLIG LYSVLVQLTN GENEREEIQV TPDYLESNNT 500
RDVRDSDLEL ITSRPAQYHT FSELPILIQQ I 531
Length:531
Mass (Da):58,744
Last modified:December 16, 2008 - v1
Checksum:iEDB63911A328C6AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285261 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285261 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali P0C8K9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAF0007377.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

CGDi CAF0007377. COX1.

Phylogenomic databases

eggNOGi COG0843.
OrthoDBi EOG72C58S.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans."
    Anderson J.B., Wickens C., Khan M., Cowen L.E., Federspiel N.A., Jones T., Kohn L.M.
    J. Bacteriol. 183:865-872(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCOX1_CANAL
AccessioniPrimary (citable) accession number: P0C8K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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