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Protein

D-tagatose-1,6-bisphosphate aldolase subunit KbaZ

Gene

kbaZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of KbaY. When expressed alone, KbaZ does not show any aldolase activity.1 Publication

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. D-tagatose-1,6-bisphosphate aldolase subunit GatZ (gatZ), D-tagatose-1,6-bisphosphate aldolase subunit GatY (gatY), D-tagatose-1,6-bisphosphate aldolase subunit KbaY (kbaY), D-tagatose-1,6-bisphosphate aldolase subunit KbaZ (kbaZ)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7631-MONOMER.
MetaCyc:G7631-MONOMER.
SABIO-RKP0C8K0.
UniPathwayiUPA00704; UER00716.

Names & Taxonomyi

Protein namesi
Recommended name:
D-tagatose-1,6-bisphosphate aldolase subunit KbaZ
Gene namesi
Name:kbaZ
Synonyms:agaZ, yhaX
Ordered Locus Names:b3132, JW3101
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12763. kbaZ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426D-tagatose-1,6-bisphosphate aldolase subunit KbaZPRO_0000064493Add
BLAST

Proteomic databases

PaxDbiP0C8K0.

Interactioni

Subunit structurei

Forms a complex with KbaY.

Protein-protein interaction databases

BioGridi4263374. 9 interactions.
DIPiDIP-9075N.
IntActiP0C8K0. 7 interactions.
STRINGi511145.b3132.

Structurei

3D structure databases

ProteinModelPortaliP0C8K0.
SMRiP0C8K0. Positions 4-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GatZ/KbaZ family. KbaZ subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C6Q. Bacteria.
COG4573. LUCA.
HOGENOMiHOG000263918.
InParanoidiP0C8K0.
KOiK16371.
OMAiGPNPWKH.
OrthoDBiEOG65XMX3.
PhylomeDBiP0C8K0.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01295. Tagatose_aldol_KbaZ.
InterProiIPR013785. Aldolase_TIM.
IPR012062. TagBP_ald_GatZ/KbaZ.
IPR023435. TagBP_ald_KbaZ.
[Graphical view]
PfamiPF08013. Tagatose_6_P_K. 1 hit.
[Graphical view]
PIRSFiPIRSF009264. TagBP_ald_AgaZ. 1 hit.
TIGRFAMsiTIGR02810. agaZ_gatZ. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C8K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLTEMVRQ HKAGKTNGIY AVCSAHPLVL EAAIRYASAN QTPLLIEATS
60 70 80 90 100
NQVDQFGGYT GMTPADFRGF VCQLADSLNF PQDALILGGD HLGPNRWQNL
110 120 130 140 150
PAAQAMANAD DLIKSYVAAG FKKIHLDCSM SCQDDPIPLT DDIVAERAAR
160 170 180 190 200
LAKVAEETCL EHFGEADLEY VIGTEVPVPG GAHETLSELA VTTPDAARAT
210 220 230 240 250
LEAHRHAFEK QGLNAIWPRI IALVVQPGVE FDHTNVIDYQ PAKASALSQM
260 270 280 290 300
VENYETLIFE AHSTDYQTPQ SLRQLVIDHF AILKVGPALT FALREALFSL
310 320 330 340 350
AAIEEELVPA KACSGLRQVL EDVMLDRPEY WQSHYHGDGN ARRLARGYSY
360 370 380 390 400
SDRVRYYWPD SQIDDAFAHL VRNLADSPIP LPLISQYLPL QYVKVRSGEL
410 420
QPTPRELIIN HIQDILAQYH TACEGQ
Length:426
Mass (Da):47,192
Last modified:November 25, 2008 - v1
Checksum:iFC97956E662EA939
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57935.1.
U00096 Genomic DNA. Translation: AAC76166.1.
AP009048 Genomic DNA. Translation: BAE77179.1.
PIRiH65102.
RefSeqiNP_417601.1. NC_000913.3.
WP_000681920.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76166; AAC76166; b3132.
BAE77179; BAE77179; BAE77179.
GeneIDi947637.
KEGGiecj:JW3101.
eco:b3132.
PATRICi32121680. VBIEscCol129921_3226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57935.1.
U00096 Genomic DNA. Translation: AAC76166.1.
AP009048 Genomic DNA. Translation: BAE77179.1.
PIRiH65102.
RefSeqiNP_417601.1. NC_000913.3.
WP_000681920.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0C8K0.
SMRiP0C8K0. Positions 4-423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263374. 9 interactions.
DIPiDIP-9075N.
IntActiP0C8K0. 7 interactions.
STRINGi511145.b3132.

Proteomic databases

PaxDbiP0C8K0.

Protocols and materials databases

DNASUi947637.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76166; AAC76166; b3132.
BAE77179; BAE77179; BAE77179.
GeneIDi947637.
KEGGiecj:JW3101.
eco:b3132.
PATRICi32121680. VBIEscCol129921_3226.

Organism-specific databases

EchoBASEiEB2616.
EcoGeneiEG12763. kbaZ.

Phylogenomic databases

eggNOGiENOG4105C6Q. Bacteria.
COG4573. LUCA.
HOGENOMiHOG000263918.
InParanoidiP0C8K0.
KOiK16371.
OMAiGPNPWKH.
OrthoDBiEOG65XMX3.
PhylomeDBiP0C8K0.

Enzyme and pathway databases

UniPathwayiUPA00704; UER00716.
BioCyciEcoCyc:G7631-MONOMER.
MetaCyc:G7631-MONOMER.
SABIO-RKP0C8K0.

Miscellaneous databases

PROiP0C8K0.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01295. Tagatose_aldol_KbaZ.
InterProiIPR013785. Aldolase_TIM.
IPR012062. TagBP_ald_GatZ/KbaZ.
IPR023435. TagBP_ald_KbaZ.
[Graphical view]
PfamiPF08013. Tagatose_6_P_K. 1 hit.
[Graphical view]
PIRSFiPIRSF009264. TagBP_ald_AgaZ. 1 hit.
TIGRFAMsiTIGR02810. agaZ_gatZ. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Novel phosphotransferase genes revealed by bacterial genome sequencing: a gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in Escherichia coli."
    Reizer J., Ramseier T.M., Reizer A., Charbit A., Saier M.H. Jr.
    Microbiology 142:231-250(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.
  4. "Two class II D-tagatose-bisphosphate aldolases from enteric bacteria."
    Brinkkoetter A., Shakeri-Garakani A., Lengeler J.W.
    Arch. Microbiol. 177:410-419(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A TAGBP ALDOLASE COMPONENT, COMPLEX WITH KBAY.

Entry informationi

Entry nameiKBAZ_ECOLI
AccessioniPrimary (citable) accession number: P0C8K0
Secondary accession number(s): P42903, Q2M977
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: June 8, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

In contrast to E.coli strains C and EC3132, K-12 strains cannot grow on N-acetylgalactosamine and D-galactosamine, because they carry a deletion and thus lack active PTS systems specific for these compounds. Therefore, KbaYZ in K-12 strains is not involved in the degradation of these compounds.

Caution

Was originally thought to be a tagatose 6-phosphate kinase.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.