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Protein

D-tagatose-1,6-bisphosphate aldolase subunit KbaZ

Gene

kbaZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of KbaY. When expressed alone, KbaZ does not show any aldolase activity.1 Publication

Miscellaneous

In contrast to E.coli strains C and EC3132, K-12 strains cannot grow on N-acetylgalactosamine and D-galactosamine, because they carry a deletion and thus lack active PTS systems specific for these compounds. Therefore, KbaYZ in K-12 strains is not involved in the degradation of these compounds.

Caution

Was originally thought to be a tagatose 6-phosphate kinase.1 Publication

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. D-tagatose-1,6-bisphosphate aldolase subunit GatZ (gatZ), D-tagatose-1,6-bisphosphate aldolase subunit GatY (gatY), D-tagatose-1,6-bisphosphate aldolase subunit KbaY (kbaY), D-tagatose-1,6-bisphosphate aldolase subunit KbaZ (kbaZ)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyciEcoCyc:G7631-MONOMER
MetaCyc:G7631-MONOMER
SABIO-RKP0C8K0
UniPathwayiUPA00704; UER00716

Names & Taxonomyi

Protein namesi
Recommended name:
D-tagatose-1,6-bisphosphate aldolase subunit KbaZ
Gene namesi
Name:kbaZ
Synonyms:agaZ, yhaX
Ordered Locus Names:b3132, JW3101
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12763 kbaZ

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000644931 – 426D-tagatose-1,6-bisphosphate aldolase subunit KbaZAdd BLAST426

Proteomic databases

PaxDbiP0C8K0
PRIDEiP0C8K0

Interactioni

Subunit structurei

Forms a complex with KbaY.

Protein-protein interaction databases

BioGridi4263374, 9 interactors
DIPiDIP-9075N
IntActiP0C8K0, 7 interactors
STRINGi316385.ECDH10B_3305

Structurei

3D structure databases

ProteinModelPortaliP0C8K0
SMRiP0C8K0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GatZ/KbaZ family. KbaZ subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C6Q Bacteria
COG4573 LUCA
HOGENOMiHOG000263918
InParanoidiP0C8K0
KOiK16371
OMAiQRHFSYS
PhylomeDBiP0C8K0

Family and domain databases

Gene3Di3.20.20.70, 2 hits
HAMAPiMF_01295 Tagatose_aldol_KbaZ, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012062 TagBP_ald_GatZ/KbaZ
IPR023435 TagBP_ald_KbaZ
PfamiView protein in Pfam
PF08013 Tagatose_6_P_K, 1 hit
PIRSFiPIRSF009264 TagBP_ald_AgaZ, 1 hit
TIGRFAMsiTIGR02810 agaZ_gatZ, 1 hit

Sequencei

Sequence statusi: Complete.

P0C8K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLTEMVRQ HKAGKTNGIY AVCSAHPLVL EAAIRYASAN QTPLLIEATS
60 70 80 90 100
NQVDQFGGYT GMTPADFRGF VCQLADSLNF PQDALILGGD HLGPNRWQNL
110 120 130 140 150
PAAQAMANAD DLIKSYVAAG FKKIHLDCSM SCQDDPIPLT DDIVAERAAR
160 170 180 190 200
LAKVAEETCL EHFGEADLEY VIGTEVPVPG GAHETLSELA VTTPDAARAT
210 220 230 240 250
LEAHRHAFEK QGLNAIWPRI IALVVQPGVE FDHTNVIDYQ PAKASALSQM
260 270 280 290 300
VENYETLIFE AHSTDYQTPQ SLRQLVIDHF AILKVGPALT FALREALFSL
310 320 330 340 350
AAIEEELVPA KACSGLRQVL EDVMLDRPEY WQSHYHGDGN ARRLARGYSY
360 370 380 390 400
SDRVRYYWPD SQIDDAFAHL VRNLADSPIP LPLISQYLPL QYVKVRSGEL
410 420
QPTPRELIIN HIQDILAQYH TACEGQ
Length:426
Mass (Da):47,192
Last modified:November 25, 2008 - v1
Checksum:iFC97956E662EA939
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57935.1
U00096 Genomic DNA Translation: AAC76166.1
AP009048 Genomic DNA Translation: BAE77179.1
PIRiH65102
RefSeqiNP_417601.1, NC_000913.3
WP_000681920.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76166; AAC76166; b3132
BAE77179; BAE77179; BAE77179
GeneIDi947637
KEGGiecj:JW3101
eco:b3132
PATRICifig|1411691.4.peg.3599

Similar proteinsi

Entry informationi

Entry nameiKBAZ_ECOLI
AccessioniPrimary (citable) accession number: P0C8K0
Secondary accession number(s): P42903, Q2M977
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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