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Protein

D-tagatose-1,6-bisphosphate aldolase subunit GatZ

Gene

gatZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GatY. When expressed alone, GatZ does not show any aldolase activity. Is involved in the catabolism of galactitol.2 Publications

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. D-tagatose-1,6-bisphosphate aldolase subunit GatZ (gatZ), D-tagatose-1,6-bisphosphate aldolase subunit GatY (gatY), D-tagatose-1,6-bisphosphate aldolase subunit KbaY (kbaY), D-tagatose-1,6-bisphosphate aldolase subunit KbaZ (kbaZ)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGalactitol metabolism

Enzyme and pathway databases

BioCyciEcoCyc:G7128-MONOMER
MetaCyc:G7128-MONOMER
SABIO-RKP0C8J8
UniPathwayiUPA00704; UER00716

Names & Taxonomyi

Protein namesi
Recommended name:
D-tagatose-1,6-bisphosphate aldolase subunit GatZ
Gene namesi
Name:gatZ
Ordered Locus Names:b2095, JW2082
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12418 gatZ

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874331 – 420D-tagatose-1,6-bisphosphate aldolase subunit GatZAdd BLAST420

Proteomic databases

PaxDbiP0C8J8
PRIDEiP0C8J8

Expressioni

Inductioni

Constitutively expressed.1 Publication

Interactioni

Subunit structurei

Forms a complex with GatY.

Protein-protein interaction databases

BioGridi4260431, 10 interactors
DIPiDIP-48243N
IntActiP0C8J8, 17 interactors
STRINGi316407.1736821

Structurei

3D structure databases

ProteinModelPortaliP0C8J8
SMRiP0C8J8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GatZ/KbaZ family. GatZ subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C6Q Bacteria
COG4573 LUCA
HOGENOMiHOG000263918
InParanoidiP0C8J8
KOiK16371
OMAiEQIGICS
PhylomeDBiP0C8J8

Family and domain databases

Gene3Di3.20.20.70, 2 hits
HAMAPiMF_01296 Tagatose_aldol_GatZ, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR023436 TagBP_ald_GatZ
IPR012062 TagBP_ald_GatZ/KbaZ
PfamiView protein in Pfam
PF08013 Tagatose_6_P_K, 1 hit
PIRSFiPIRSF009264 TagBP_ald_AgaZ, 1 hit
TIGRFAMsiTIGR02810 agaZ_gatZ, 1 hit

Sequencei

Sequence statusi: Complete.

P0C8J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLIARHKA GEHIGICSVC SAHPLVIEAA LAFDRNSTRK VLIEATSNQV
60 70 80 90 100
NQFGGYTGMT PADFREFVFT IADKVGFARE RIILGGDHLG PNCWQQENAD
110 120 130 140 150
AAMEKSVELV KEYVRAGFSK IHLDASMSCA GDPIPLAPET VAERAAVLCF
160 170 180 190 200
AAESVATDCQ REQLSYVIGT EVPVPGGEAS AIQSVHITHV EDAANTLRTH
210 220 230 240 250
QKAFIARGLT EALTRVIAIV VQPGVEFDHS NIIHYQPQEA QPLAQWIENT
260 270 280 290 300
RMVYEAHSTD YQTRTAYWEL VRDHFAILKV GPALTFALRE AIFALAQIEQ
310 320 330 340 350
ELIAPENRSG CLAVIEEVML DEPQYWKKYY RTGFNDSLLD IRYSLSDRIR
360 370 380 390 400
YYWPHSRIKN SVETMMVNLE GVDIPLGMIS QYLPKQFERI QSGELSAIPH
410 420
QLIMDKIYDV LRAYRYGCAE
Length:420
Mass (Da):47,109
Last modified:November 25, 2008 - v1
Checksum:i258D25D832E42580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75156.1
AP009048 Genomic DNA Translation: BAA15965.1
PIRiF64976
S55902
RefSeqiNP_416598.1, NC_000913.3
WP_000853883.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75156; AAC75156; b2095
BAA15965; BAA15965; BAA15965
GeneIDi946641
KEGGiecj:JW2082
eco:b2095
PATRICifig|511145.12.peg.2172

Similar proteinsi

Entry informationi

Entry nameiGATZ_ECOLI
AccessioniPrimary (citable) accession number: P0C8J8
Secondary accession number(s): P37191, P76414
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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