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Protein

D-tagatose-1,6-bisphosphate aldolase subunit GatZ

Gene

gatZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GatY. When expressed alone, GatZ does not show any aldolase activity. Is involved in the catabolism of galactitol.2 Publications

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. D-tagatose-1,6-bisphosphate aldolase subunit GatZ (gatZ), D-tagatose-1,6-bisphosphate aldolase subunit GatY (gatY), D-tagatose-1,6-bisphosphate aldolase subunit KbaY (kbaY), D-tagatose-1,6-bisphosphate aldolase subunit KbaZ (kbaZ)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Galactitol metabolism

Enzyme and pathway databases

BioCyciEcoCyc:G7128-MONOMER.
MetaCyc:G7128-MONOMER.
SABIO-RKP0C8J8.
UniPathwayiUPA00704; UER00716.

Names & Taxonomyi

Protein namesi
Recommended name:
D-tagatose-1,6-bisphosphate aldolase subunit GatZ
Gene namesi
Name:gatZ
Ordered Locus Names:b2095, JW2082
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12418. gatZ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420D-tagatose-1,6-bisphosphate aldolase subunit GatZPRO_0000087433Add
BLAST

Proteomic databases

PaxDbiP0C8J8.
PRIDEiP0C8J8.

Expressioni

Inductioni

Constitutively expressed.1 Publication

Interactioni

Subunit structurei

Forms a complex with GatY.

Protein-protein interaction databases

BioGridi4260431. 8 interactions.
DIPiDIP-48243N.
IntActiP0C8J8. 17 interactions.
STRINGi511145.b2095.

Structurei

3D structure databases

ProteinModelPortaliP0C8J8.
SMRiP0C8J8. Positions 1-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GatZ/KbaZ family. GatZ subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C6Q. Bacteria.
COG4573. LUCA.
HOGENOMiHOG000263918.
InParanoidiP0C8J8.
KOiK16371.
OMAiEQIGICS.
PhylomeDBiP0C8J8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01296. Tagatose_aldol_GatZ. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR023436. TagBP_ald_GatZ.
IPR012062. TagBP_ald_GatZ/KbaZ.
[Graphical view]
PfamiPF08013. Tagatose_6_P_K. 1 hit.
[Graphical view]
PIRSFiPIRSF009264. TagBP_ald_AgaZ. 1 hit.
TIGRFAMsiTIGR02810. agaZ_gatZ. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C8J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLIARHKA GEHIGICSVC SAHPLVIEAA LAFDRNSTRK VLIEATSNQV
60 70 80 90 100
NQFGGYTGMT PADFREFVFT IADKVGFARE RIILGGDHLG PNCWQQENAD
110 120 130 140 150
AAMEKSVELV KEYVRAGFSK IHLDASMSCA GDPIPLAPET VAERAAVLCF
160 170 180 190 200
AAESVATDCQ REQLSYVIGT EVPVPGGEAS AIQSVHITHV EDAANTLRTH
210 220 230 240 250
QKAFIARGLT EALTRVIAIV VQPGVEFDHS NIIHYQPQEA QPLAQWIENT
260 270 280 290 300
RMVYEAHSTD YQTRTAYWEL VRDHFAILKV GPALTFALRE AIFALAQIEQ
310 320 330 340 350
ELIAPENRSG CLAVIEEVML DEPQYWKKYY RTGFNDSLLD IRYSLSDRIR
360 370 380 390 400
YYWPHSRIKN SVETMMVNLE GVDIPLGMIS QYLPKQFERI QSGELSAIPH
410 420
QLIMDKIYDV LRAYRYGCAE
Length:420
Mass (Da):47,109
Last modified:November 25, 2008 - v1
Checksum:i258D25D832E42580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75156.1.
AP009048 Genomic DNA. Translation: BAA15965.1.
PIRiF64976.
S55902.
RefSeqiNP_416598.1. NC_000913.3.
WP_000853883.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75156; AAC75156; b2095.
BAA15965; BAA15965; BAA15965.
GeneIDi946641.
KEGGiecj:JW2082.
eco:b2095.
PATRICi32119523. VBIEscCol129921_2172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75156.1.
AP009048 Genomic DNA. Translation: BAA15965.1.
PIRiF64976.
S55902.
RefSeqiNP_416598.1. NC_000913.3.
WP_000853883.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0C8J8.
SMRiP0C8J8. Positions 1-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260431. 8 interactions.
DIPiDIP-48243N.
IntActiP0C8J8. 17 interactions.
STRINGi511145.b2095.

Proteomic databases

PaxDbiP0C8J8.
PRIDEiP0C8J8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75156; AAC75156; b2095.
BAA15965; BAA15965; BAA15965.
GeneIDi946641.
KEGGiecj:JW2082.
eco:b2095.
PATRICi32119523. VBIEscCol129921_2172.

Organism-specific databases

EchoBASEiEB2317.
EcoGeneiEG12418. gatZ.

Phylogenomic databases

eggNOGiENOG4105C6Q. Bacteria.
COG4573. LUCA.
HOGENOMiHOG000263918.
InParanoidiP0C8J8.
KOiK16371.
OMAiEQIGICS.
PhylomeDBiP0C8J8.

Enzyme and pathway databases

UniPathwayiUPA00704; UER00716.
BioCyciEcoCyc:G7128-MONOMER.
MetaCyc:G7128-MONOMER.
SABIO-RKP0C8J8.

Miscellaneous databases

PROiP0C8J8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01296. Tagatose_aldol_GatZ. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR023436. TagBP_ald_GatZ.
IPR012062. TagBP_ald_GatZ/KbaZ.
[Graphical view]
PfamiPF08013. Tagatose_6_P_K. 1 hit.
[Graphical view]
PIRSFiPIRSF009264. TagBP_ald_AgaZ. 1 hit.
TIGRFAMsiTIGR02810. agaZ_gatZ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGATZ_ECOLI
AccessioniPrimary (citable) accession number: P0C8J8
Secondary accession number(s): P37191, P76414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.