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P0C8G9

- FLSO_ASFWA

UniProt

P0C8G9 - FLSO_ASFWA

Protein

FAD-linked sulfhydryl oxidase

Gene

War-083

Organism
African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Involved in virion maturation By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

    Cofactori

    FAD.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. thiol oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Virulence

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FAD-linked sulfhydryl oxidase (EC:1.8.3.2)
    Alternative name(s):
    p14
    Gene namesi
    Ordered Locus Names:War-083
    OrganismiAfrican swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)
    Taxonomic identifieri561444 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAsfarviridaeAsfivirus
    Virus hostiOrnithodoros (relapsing fever ticks) [TaxID: 6937]
    Phacochoerus aethiopicus (Warthog) [TaxID: 85517]
    Phacochoerus africanus (Warthog) [TaxID: 41426]
    Potamochoerus larvatus (Bushpig) [TaxID: 273792]
    Sus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000000858: Genome

    Subcellular locationi

    Host cytoplasm By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 119119FAD-linked sulfhydryl oxidasePRO_0000355537Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi44 ↔ 47Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Inductioni

    Expressed late in the infection cycle.

    Keywords - Developmental stagei

    Late protein

    Interactioni

    Subunit structurei

    Interacts with A151R.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0C8G9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9797ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the asfivirus B119L family.Curated
    Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.20.120.310. 1 hit.
    InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
    [Graphical view]
    PfamiPF04777. Evr1_Alr. 1 hit.
    [Graphical view]
    SUPFAMiSSF69000. SSF69000. 1 hit.
    PROSITEiPS51324. ERV_ALR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C8G9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHWGPKYWR ALHLYAIFFS DAPGWKEKYE AIQWILNFIE SLPCTRCRHH    50
    AFSYLTKNPL TLNNSEDFQY WTFAFHNNVN NRLNKKIISW SEYKNIYEQS 100
    ILKTIEYGKT DFIGAWSSL 119
    Length:119
    Mass (Da):14,360
    Last modified:November 25, 2008 - v1
    Checksum:iDCFD2EF5DE1F3A87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY261366 Genomic DNA. No translation available.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY261366 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali P0C8G9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.120.310. 1 hit.
    InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
    [Graphical view ]
    Pfami PF04777. Evr1_Alr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69000. SSF69000. 1 hit.
    PROSITEi PS51324. ERV_ALR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "African swine fever virus genomes."
      Kutish G.F., Rock D.L.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiFLSO_ASFWA
    AccessioniPrimary (citable) accession number: P0C8G9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3