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Protein

FAD-linked sulfhydryl oxidase

Gene

War-083

Organism
African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Involved in virion maturation (By similarity).PROSITE-ProRule annotation

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FADPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processVirulence
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
FAD-linked sulfhydryl oxidase (EC:1.8.3.2)
Alternative name(s):
p14
Gene namesi
Ordered Locus Names:War-083
OrganismiAfrican swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)
Taxonomic identifieri561444 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAsfarviridaeAsfivirus
Virus hostiOrnithodoros (relapsing fever ticks) [TaxID: 6937]
Phacochoerus aethiopicus (Warthog) [TaxID: 85517]
Phacochoerus africanus (Warthog) [TaxID: 41426]
Potamochoerus larvatus (Bushpig) [TaxID: 273792]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000000858 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003555371 – 119FAD-linked sulfhydryl oxidaseAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 47Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

Expressed late in the infection cycle.

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with A151R.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0C8G9.
SMRiP0C8G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 97ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Belongs to the asfivirus B119L family.Curated

Phylogenomic databases

OrthoDBiVOG0900028L.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
InterProiView protein in InterPro
IPR017905. ERV/ALR_sulphydryl_oxidase.
PfamiView protein in Pfam
PF04777. Evr1_Alr. 1 hit.
SUPFAMiSSF69000. SSF69000. 1 hit.
PROSITEiView protein in PROSITE
PS51324. ERV_ALR. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C8G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHWGPKYWR ALHLYAIFFS DAPGWKEKYE AIQWILNFIE SLPCTRCRHH
60 70 80 90 100
AFSYLTKNPL TLNNSEDFQY WTFAFHNNVN NRLNKKIISW SEYKNIYEQS
110
ILKTIEYGKT DFIGAWSSL
Length:119
Mass (Da):14,360
Last modified:November 25, 2008 - v1
Checksum:iDCFD2EF5DE1F3A87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY261366 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY261366 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliP0C8G9.
SMRiP0C8G9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG0900028L.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
InterProiView protein in InterPro
IPR017905. ERV/ALR_sulphydryl_oxidase.
PfamiView protein in Pfam
PF04777. Evr1_Alr. 1 hit.
SUPFAMiSSF69000. SSF69000. 1 hit.
PROSITEiView protein in PROSITE
PS51324. ERV_ALR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFLSO_ASFWA
AccessioniPrimary (citable) accession number: P0C8G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: March 15, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.