Evasin-4 precursor - Rhipicephalus sanguineus (Brown dog tick)

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Reviewed, UniProtKB/Swiss-Prot P0C8E9 (EVA4_RHISA)

Last modified June 16, 2009. Version 4. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein names	Recommended name: Evasin-4
Organism	Rhipicephalus sanguineus (Brown dog tick)
Taxonomic identifier	34632 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Acari › Parasitiformes › Ixodida › Ixodoidea › Ixodidae › Rhipicephalinae › Rhipicephalus › Rhipicephalus

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Shows chemokine neutralizing activity. Binds to chemokines CCL5 and CCL11. Ref.1
Subunit structure	Monomer. Ref.1
Subcellular location	Secreted Potential.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

23

Potential

Chain

104

Evasin-4

PRO_0000354059

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P0C8E9-1 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: EF315B8BFE23E602
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127

14,126

        10         20         30         40         50         60 
MAFKYWFVFA AVLYARQWLS TKCEVPQMTS SSAPDLEEED DYTAYAPLTC YFTNSTLGLL 

        70         80         90        100        110        120 
APPNCSVLCN STTTWFNETS PNNASCLLTV DFLTQDAILQ ENQPYNCSVG HCDNGTCAGP 


PRHAQCW

References

[1]

"Ticks produce highly selective chemokine binding proteins with antiinflammatory activity."
Deruaz M., Frauenschuh A., Alessandri A.L., Dias J.M., Coelho F.M., Russo R.C., Ferreira B.R., Graham G.J., Shaw J.P., Wells T.N.C., Teixeira M.M., Power C.A., Proudfoot A.E.I.
J. Exp. Med. 205:2019-2031(2008) [PubMed: 18678732] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, FUNCTION.
Tissue: Salivary gland.

Web resources

Protein Spotlight

Hidden powers - Issue 99 of November 2008

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

EVA4_RHISA

Accession

Primary (citable) accession number: P0C8E9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	June 16, 2009
This is version 4 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents