P0C8E9 (EVA4_RHISA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Evasin-4
Organism	Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Taxonomic identifier	34632 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Parasitiformes › Ixodida › Ixodoidea › Ixodidae › Rhipicephalinae › Rhipicephalus › Rhipicephalus › Rhipicephalus sanguineus group

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Shows chemokine neutralizing activity. Binds to chemokines CCL5 and CCL11. Ref.1
Subunit structure	Monomer. Ref.1
Subcellular location	Secreted Potential.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 127	104	Evasin-4		PRO_0000354059
Amino acid modifications
	Glycosylation	54	1	N-linked (GlcNAc...) Potential
	Glycosylation	64	1	N-linked (GlcNAc...) Potential
	Glycosylation	70	1	N-linked (GlcNAc...) Potential
	Glycosylation	77	1	N-linked (GlcNAc...) Potential
	Glycosylation	83	1	N-linked (GlcNAc...) Potential
	Glycosylation	106	1	N-linked (GlcNAc...) Potential
	Glycosylation	114	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P0C8E9 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: EF315B8BFE23E602	FASTA	127	14,126
	10 20 30 40 50 60 MAFKYWFVFA AVLYARQWLS TKCEVPQMTS SSAPDLEEED DYTAYAPLTC YFTNSTLGLL 70 80 90 100 110 120 APPNCSVLCN STTTWFNETS PNNASCLLTV DFLTQDAILQ ENQPYNCSVG HCDNGTCAGP PRHAQCW

References

[1]

"Ticks produce highly selective chemokine binding proteins with antiinflammatory activity." Deruaz M., Frauenschuh A., Alessandri A.L., Dias J.M., Coelho F.M., Russo R.C., Ferreira B.R., Graham G.J., Shaw J.P., Wells T.N.C., Teixeira M.M., Power C.A., Proudfoot A.E.I. J. Exp. Med. 205:2019-2031(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, FUNCTION. Tissue: Salivary gland.

Web resources

Protein Spotlight

Hidden powers - Issue 99 of November 2008

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR007110. Ig-like_dom. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EVA4_RHISA

Accession

Primary (citable) accession number: P0C8E9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	March 6, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)