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P0C8E7 (EVA1_RHISA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Shows chemokine neutralizing activity. Binds to chemokines CCL3, CCL4 and CCL18. Ref.1 Ref.2

Subunit structure

Monomer. Ref.1

Subcellular location

Secreted Probable.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   PTMGlycoprotein
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.1
Chain21 – 11494Evasin-1
PRO_0000354057

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation621N-linked (GlcNAc...) Potential

Secondary structure

..................... 114
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0C8E7 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 1CDFB331167EE2CF

FASTA11412,593
        10         20         30         40         50         60 
MTFKACIAII TALCAMQVIC EDDEDYGDLG GCPFLVAENK TGYPTIVACK QDCNGTTETA 

        70         80         90        100        110 
PNGTRCFSIG DEGLRRMTAN LPYDCPLGQC SNGDCIPKET YEVCYRRNWR DKKN 

« Hide

References

[1]"Molecular cloning and characterization of a highly selective chemokine-binding protein from the tick Rhipicephalus sanguineus."
Frauenschuh A., Power C.A., Deruaz M., Ferreira B.R., Silva J.S., Teixeira M.M., Dias J.M., Martin T., Wells T.N.C., Proudfoot A.E.I.
J. Biol. Chem. 282:27250-27258(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, SUBUNIT, FUNCTION.
Tissue: Salivary gland.
[2]"Ticks produce highly selective chemokine binding proteins with antiinflammatory activity."
Deruaz M., Frauenschuh A., Alessandri A.L., Dias J.M., Coelho F.M., Russo R.C., Ferreira B.R., Graham G.J., Shaw J.P., Wells T.N.C., Teixeira M.M., Power C.A., Proudfoot A.E.I.
J. Exp. Med. 205:2019-2031(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Hidden powers - Issue 99 of November 2008

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3FPRX-ray1.63A/D21-114[»]
3FPTX-ray2.70A/B/C21-114[»]
3FPUX-ray1.76A21-114[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Other

EvolutionaryTraceP0C8E7.

Entry information

Entry nameEVA1_RHISA
AccessionPrimary (citable) accession number: P0C8E7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: February 19, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references