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P0C8E7

- EVA1_RHISA

UniProt

P0C8E7 - EVA1_RHISA

Protein

Evasin-1

Gene
N/A
Organism
Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Shows chemokine neutralizing activity. Binds to chemokines CCL3, CCL4 and CCL18.2 Publications

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Evasin-1
    OrganismiRhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
    Taxonomic identifieri34632 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 11494Evasin-1PRO_0000354057Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Structurei

    Secondary structure

    1
    114
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi25 – 273
    Beta strandi34 – 385
    Beta strandi44 – 474
    Beta strandi49 – 535
    Beta strandi56 – 594
    Beta strandi65 – 673
    Helixi70 – 767
    Beta strandi83 – 919
    Beta strandi94 – 10512
    Helixi109 – 1124

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3FPRX-ray1.63A/D21-114[»]
    3FPTX-ray2.70A/B/C21-114[»]
    3FPUX-ray1.76A21-114[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0C8E7.

    Family & Domainsi

    Keywords - Domaini

    Signal

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C8E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTFKACIAII TALCAMQVIC EDDEDYGDLG GCPFLVAENK TGYPTIVACK    50
    QDCNGTTETA PNGTRCFSIG DEGLRRMTAN LPYDCPLGQC SNGDCIPKET 100
    YEVCYRRNWR DKKN 114
    Length:114
    Mass (Da):12,593
    Last modified:November 25, 2008 - v1
    Checksum:i1CDFB331167EE2CF
    GO

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Hidden powers - Issue 99 of November 2008

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3FPR X-ray 1.63 A/D 21-114 [» ]
    3FPT X-ray 2.70 A/B/C 21-114 [» ]
    3FPU X-ray 1.76 A 21-114 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P0C8E7.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a highly selective chemokine-binding protein from the tick Rhipicephalus sanguineus."
      Frauenschuh A., Power C.A., Deruaz M., Ferreira B.R., Silva J.S., Teixeira M.M., Dias J.M., Martin T., Wells T.N.C., Proudfoot A.E.I.
      J. Biol. Chem. 282:27250-27258(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, SUBUNIT, FUNCTION.
      Tissue: Salivary gland.
    2. Cited for: FUNCTION.

    Entry informationi

    Entry nameiEVA1_RHISA
    AccessioniPrimary (citable) accession number: P0C8E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

    External Data

    Dasty 3