P0C8E7 (EVA1_RHISA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Evasin-1
Organism	Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Taxonomic identifier	34632 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Parasitiformes › Ixodida › Ixodoidea › Ixodidae › Rhipicephalinae › Rhipicephalus › Rhipicephalus › Rhipicephalus sanguineus group

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Shows chemokine neutralizing activity. Binds to chemokines CCL3, CCL4 and CCL18. Ref.1 Ref.2
Subunit structure	Monomer. Ref.1
Subcellular location	Secreted Probable.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

20

Ref.1

Chain

21 – 114

94

Evasin-1

PRO_0000354057

Amino acid modifications

Glycosylation

39

1

N-linked (GlcNAc...) Potential

Glycosylation

54

1

N-linked (GlcNAc...) Potential

Glycosylation

62

1

N-linked (GlcNAc...) Potential

Secondary structure

1

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114

Helix Strand Turn

Details...

Beta strand

25 – 27

3

Beta strand

34 – 38

5

Beta strand

44 – 47

4

Beta strand

49 – 53

5

Beta strand

56 – 59

4

Beta strand

65 – 67

3

Helix

70 – 76

7

Beta strand

83 – 91

9

Beta strand

94 – 105

12

Helix

109 – 112

4

Sequences

	Sequence		Length	Mass (Da)
	P0C8E7 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: 1CDFB331167EE2CF	FASTA	114	12,593
	10 20 30 40 50 60 MTFKACIAII TALCAMQVIC EDDEDYGDLG GCPFLVAENK TGYPTIVACK QDCNGTTETA 70 80 90 100 110 PNGTRCFSIG DEGLRRMTAN LPYDCPLGQC SNGDCIPKET YEVCYRRNWR DKKN

References

[1]	"Molecular cloning and characterization of a highly selective chemokine-binding protein from the tick Rhipicephalus sanguineus." Frauenschuh A., Power C.A., Deruaz M., Ferreira B.R., Silva J.S., Teixeira M.M., Dias J.M., Martin T., Wells T.N.C., Proudfoot A.E.I. J. Biol. Chem. 282:27250-27258(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, SUBUNIT, FUNCTION. Tissue: Salivary gland.
[2]	"Ticks produce highly selective chemokine binding proteins with antiinflammatory activity." Deruaz M., Frauenschuh A., Alessandri A.L., Dias J.M., Coelho F.M., Russo R.C., Ferreira B.R., Graham G.J., Shaw J.P., Wells T.N.C., Teixeira M.M., Power C.A., Proudfoot A.E.I. J. Exp. Med. 205:2019-2031(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Hidden powers - Issue 99 of November 2008

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3FPR	X-ray	1.63	A/D	21-114	[»]
3FPT	X-ray	2.70	A/B/C	21-114	[»]
3FPU	X-ray	1.76	A	21-114	[»]

ModBase

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Protocols and materials databases

StructuralBiologyKnowledgebase

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Family and domain databases

ProtoNet

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Other

EvolutionaryTrace

P0C8E7.

Entry information

Entry name

EVA1_RHISA

Accession

Primary (citable) accession number: P0C8E7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	October 3, 2012
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)