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Protein

Evasin-1

Gene
N/A
Organism
Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Shows chemokine neutralizing activity. Binds to chemokines CCL3, CCL4 and CCL18.2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Evasin-1
OrganismiRhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Taxonomic identifieri34632 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 11494Evasin-1PRO_0000354057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

1
114
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 273Combined sources
Beta strandi34 – 385Combined sources
Beta strandi44 – 474Combined sources
Beta strandi49 – 535Combined sources
Beta strandi56 – 594Combined sources
Beta strandi65 – 673Combined sources
Helixi70 – 767Combined sources
Beta strandi83 – 919Combined sources
Beta strandi94 – 10512Combined sources
Helixi109 – 1124Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FPRX-ray1.63A/D21-114[»]
3FPTX-ray2.70A/B/C21-114[»]
3FPUX-ray1.76A21-114[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C8E7.

Family & Domainsi

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C8E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFKACIAII TALCAMQVIC EDDEDYGDLG GCPFLVAENK TGYPTIVACK
60 70 80 90 100
QDCNGTTETA PNGTRCFSIG DEGLRRMTAN LPYDCPLGQC SNGDCIPKET
110
YEVCYRRNWR DKKN
Length:114
Mass (Da):12,593
Last modified:November 24, 2008 - v1
Checksum:i1CDFB331167EE2CF
GO

Cross-referencesi

Web resourcesi

Protein Spotlight

Hidden powers - Issue 99 of November 2008

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FPRX-ray1.63A/D21-114[»]
3FPTX-ray2.70A/B/C21-114[»]
3FPUX-ray1.76A21-114[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP0C8E7.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of a highly selective chemokine-binding protein from the tick Rhipicephalus sanguineus."
    Frauenschuh A., Power C.A., Deruaz M., Ferreira B.R., Silva J.S., Teixeira M.M., Dias J.M., Martin T., Wells T.N.C., Proudfoot A.E.I.
    J. Biol. Chem. 282:27250-27258(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, SUBUNIT, FUNCTION.
    Tissue: Salivary gland.
  2. Cited for: FUNCTION.

Entry informationi

Entry nameiEVA1_RHISA
AccessioniPrimary (citable) accession number: P0C8E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2008
Last sequence update: November 24, 2008
Last modified: January 6, 2015
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.