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P0C8E7

- EVA1_RHISA

UniProt

P0C8E7 - EVA1_RHISA

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Protein
Evasin-1
Gene
N/A
Organism
Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Shows chemokine neutralizing activity. Binds to chemokines CCL3, CCL4 and CCL18.2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Evasin-1
OrganismiRhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Taxonomic identifieri34632 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 Publication
Add
BLAST
Chaini21 – 11494Evasin-1
PRO_0000354057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi54 – 541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi62 – 621N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 273
Beta strandi34 – 385
Beta strandi44 – 474
Beta strandi49 – 535
Beta strandi56 – 594
Beta strandi65 – 673
Helixi70 – 767
Beta strandi83 – 919
Beta strandi94 – 10512
Helixi109 – 1124

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FPRX-ray1.63A/D21-114[»]
3FPTX-ray2.70A/B/C21-114[»]
3FPUX-ray1.76A21-114[»]

Miscellaneous databases

EvolutionaryTraceiP0C8E7.

Family & Domainsi

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C8E7-1 [UniParc]FASTAAdd to Basket

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MTFKACIAII TALCAMQVIC EDDEDYGDLG GCPFLVAENK TGYPTIVACK    50
QDCNGTTETA PNGTRCFSIG DEGLRRMTAN LPYDCPLGQC SNGDCIPKET 100
YEVCYRRNWR DKKN 114
Length:114
Mass (Da):12,593
Last modified:November 25, 2008 - v1
Checksum:i1CDFB331167EE2CF
GO

Cross-referencesi

Web resourcesi

Protein Spotlight

Hidden powers - Issue 99 of November 2008

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3FPR X-ray 1.63 A/D 21-114 [» ]
3FPT X-ray 2.70 A/B/C 21-114 [» ]
3FPU X-ray 1.76 A 21-114 [» ]
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P0C8E7.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a highly selective chemokine-binding protein from the tick Rhipicephalus sanguineus."
    Frauenschuh A., Power C.A., Deruaz M., Ferreira B.R., Silva J.S., Teixeira M.M., Dias J.M., Martin T., Wells T.N.C., Proudfoot A.E.I.
    J. Biol. Chem. 282:27250-27258(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, SUBUNIT, FUNCTION.
    Tissue: Salivary gland.
  2. Cited for: FUNCTION.

Entry informationi

Entry nameiEVA1_RHISA
AccessioniPrimary (citable) accession number: P0C8E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: February 19, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

External Data

Dasty 3

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